Chicago Cubs vs Atlanta Braves Prediction 9/10/2025 Today’s MLB Picks

The Chicago Cubs and the Atlanta Braves meet Wednesday in MLB action from Truist Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Atlanta Braves prediction.

Starting Pitching Matchup

The Chicago Cubs did not have a starting pitcher confirmed at the time that this article was posted. The Atlanta Braves will trot out Chris Sale for the start here and Sale is 5-4 with a 2.38 ERA and 132 strikeouts this season. In his career, Sale is 3-1 with a 1.00 ERA and 38 strikeouts against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to build on their 6-1 win over Atlanta last time out to sit at 82-63 this season. After this series, the Cubs will head home for a series against the Tampa Bay Rays.

Cubs Snap Three-Game Losing Streak

Ian Happ has 120 hits with 27 doubles, 20 home runs and 66 RBIs. Kyle Tucker has 132 hits including 25 doubles, 4 triples, 22 home runs and 73 RBIs while Seiya Suzuki also has 130 hits with 29 doubles and 27 home runs and 90 RBIs of his own. Pete Crow-Armstrong also has contributed 134 hits, 35 doubles, 4 triples, 28 home runs and 87 RBIs as well this season. Dansby Swanson has added 22 home runs and 71 RBIs, while also having 153 strikeouts and Suzuki has 156 strikeouts so far this season. Crow-Armstrong also has a team-high 34 stolen bases while Nico Hoerner has 24 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 19 doubles, 4 triples, 26 home runs and 76 RBIs this season.

Atlanta Braves Recap

The Atlanta Braves come into this game looking to rebound from their loss at the hands of the Cubs to sit at 65-80 this season. After this series, the Braves will head home for a series against the Houston Astros.

Braves Looking To Bounce Back

Austin Riley has 108 hits including 16 home runs, 54 RBIs and 20 doubles so far this season. Ozzie Albies has 134 hits with 16 home runs and 65 RBIs in addition to 14 stolen bases and Matt Olson has 150 hits with 36 doubles, 23 home runs and 80 RBIs of his own. Marcell Ozuna also has 98 hits with 20 home runs and 62 RBIs. Michael Harris II also has 133 hits with 22 doubles, 6 triples, 17 home runs and 79 RBIs and 15 stolen bases as well and Nick Allen has 8 stolen bases as well this season.

The Chicago Cubs @ Atlanta Braves Betting Trends: September 10, 2025

• Probable Starting Pitcher: Chris Sale      Record this season: 5-4      ERA: 2.38
• Home Record: 1-1
• Last 5 against Cubs: 3-1

Why the Atlanta Braves will win

• The Cubs have lost each of their last 11 games as underdogs against NL East opponents following a win.
• The Braves have won each of their last six home games against the Cubs following a loss.
• The Braves have covered the run line in each of their last eight games against National League opponents following a loss.
• The Cubs have failed to cover the run line each of their last 10 Wednesday games against teams that held a losing record.
• The Cubs have trailed after 5 innings in six of their last seven games as underdogs against NL East opponents.

• Probable Starting Pitcher: Jameson Taillon      Record this season: 9-6      ERA: 4.15
• Road Record: 5-4
• Last 5 against Braves: 1-1

Why the Chicago Cubs will win

• The Cubs have won four of their last five games as underdogs after playing the previous day.
• The Braves have lost eight of their last 10 games as favorites against NL Central opponents following a home loss.
• The Braves have failed to cover the run line in 16 of their last 18 games as home favorites against NL Central opponents.
• The Cubs have covered the run line in each of their last five games as underdogs after playing the previous day.
• The Braves have trailed after 3 innings in five of their last six home games against National League opponents.
• The Braves have trailed after 5 innings in nine of their last 10 home games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Braves’ last seven night games against National League opponents have gone UNDER the total runs line.
• Seven of the Cubs’ last eight night games against NL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last four games at Truist Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Braves’ last four games as favorites.

Atlanta Braves Player Prop Facts

• Ozzie Albies has hit a home run in three of the Braves’ last four games against the Cubs.
• Chris Sale has recorded seven or more strikeouts in each of his last six appearances.
• Chris Sale has recorded a win in each of his last three appearances with his team as a favorite against the Cubs.
• Austin Riley has recorded at least one hit in each of his last 10 home appearances against NL Central opponents.

Chicago Cubs Player Prop Facts

• Ian Happ has hit at least one home run in three of the Cubs’ last six road games against NL East opponents.
• Jameson Taillon has recorded five or more strikeouts in 11 of his last 12 Wednesday appearances against teams that held a losing record.
• Jameson Taillon has recorded a win in seven of his last eight appearances against opponents that held a losing record.
• Kyle Tucker has recorded a Double in three of his last four road appearances.
• Kyle Tucker has recorded at least one hit in 15 of his last 16 road appearances against opponents that held a losing record.

Matchup/League Facts

• The Braves rank 4th in the league for walks this season (506).
• The Braves rank 26th in the league for doubles this season (217).
• The Cubs rank 1st in the league for walks allowed this season (368).
• The Cubs rank 3rd in the league for steals this season (146).

Chicago Cubs vs. Atlanta Braves Prediction

I’m backing the Braves in this one. I just think that the Braves get a strong start from Chris Sale, who has owned the Cubs for the course of his entire career and I think his matchup from a lineup perspective cancels out, so with a clear edge in starting pitching regardless of who the Cubs send out here, I have to roll with Atlanta in this one.