St. Louis Cardinals vs Milwaukee Brewers Prediction 9/12/2025 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB game on Friday, September 12th at the American Family Field the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have an 89-58 record this season and are sitting on the first place of the NL Central. They have a 46-26 home record and are 70-72 in over/under. They are coming off a 3-6 road defeat by the Rangers, and have three straight losses, having being swept in that series. Over is 3-1 in their last 4 games and are playing the Cardinals and the Angels next.

The Brewers have a .260 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 154 hits, while Christian Yelich leads the team in RBI, with 93, adding a team-high 27 home runs. Sal Frelick is the team’s best hitter with a .294 batting average.

Quinn Priester (R) is the projected starting pitcher for the Brewers, and he has a 12-2 record, 3.25 ERA and 1.23 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-75 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 31-41 road record and are 73-66 in over/under. They are coming off a 3-5 road defeat by the Mariners, and have back-to-back losses. Under is 5-2 in their last 7 games and are playing the Brewers and the Reds next.

The Cardinals have a .244 batting average this season, .313 OBP and .379 Slugging percentage. Saint Louis’ pitching staff has a 4.26 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 125 hits, and he is the team’s best hitter with a .282 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 6-13 record, 5.28 ERA and 1.43 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 12, 2025

• Probable Starting Pitcher: Quinn Priester      Record this season: 12-2      ERA: 3.25
• Home Record: 6-1
• Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight games against NL Central opponents that held a losing record.
• The Cardinals have lost each of their last four road games.
• The Brewers have covered the run line each of their last eight games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line in each of their last five games following a road loss.
• The Brewers have led after 5 innings in seven of their last eight home games against NL Central opponents.
• The Brewers have led after 3 innings in seven of their last eight home games against NL Central opponents.
• The Cardinals have lost the first inning in four of their last five road games against NL Central opponents that held a winning record.

• Probable Starting Pitcher: Andre Pallante      Record this season: 6-13      ERA: 5.28
• Road Record: 2-7
• Last 5 against Brewers: 0-1

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six games as underdogs against National League opponents following a loss.
• The Brewers have lost each of their last five games as favorites following a road loss.
• The Brewers have failed to cover the run line in each of their last eight games as favorites following a road loss.
• The underdogs have covered the run line in each of the Brewers’ last six games at American Family Field.
• The Cardinals have led after 5 innings in four of their last five night games against NL Central opponents.
• The Brewers have trailed after 3 innings in three of their last four night games against NL Central opponents.

Total Runs Facts

• Seven of the Cardinals’ last eight games following an extra innings loss have gone OVER the total runs line.
• Five of the Brewers’ last six home games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last three night games.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last four appearances in night games against NL Central teams that held a losing record.
• Andrew Vaughn has recorded a Double in three of the Brewers’ last four games against NL opponents.
• Christian Yelich has recorded at least one hit in each of his last 18 appearances against NL Central opponents that held a losing record.
• Sal Frelick ranks 8th amongst qualified players for Batting Average (.294) this season.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in two of his last three road appearances against NL opponents that held a winning record.
• Alec Burleson has recorded a hit in each of his eight previous appearances against the Brewers after not playing the previous day.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for runs scored this season (743).
• The Brewers rank 2nd in the league for on-base percentage this season (.333).
• The Cardinals rank 30th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1086).

Cardinals vs Brewers Prediction

The Brewers are 4-1 in their last 5 meetings against the Cardinals, but both teams are tied 3-3 wins in their last 6 meetings in Milwaukee. Under is 6-2 in their last 8 meetings.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -185 home favorites. Milwaukee has a huge pitching advantage, as Priester has been a winning machine this season, with a 12-2 record, with the Brewers having won the last 14 games he has started. On the flip side, Pallante has been mediocre this season and in poor form lately, with a 1-4 record and 6.84 ERA in his last 5 starts. Milwaukee has both a better bullpen and a better offense and I expect to dominate this game for a bounce-back win.