Seattle Mariners vs Kansas City Royals Prediction 9/17/2025 Today’s MLB Picks

The Seattle Mariners and Kansas City Royals meet Wednesday in MLB action at Kauffman Stadium. Here’s a Seattle Mariners vs Kansas City Royals Prediction. This article will include a Seattle Mariners vs Kansas City Royals Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 83-68 on the year and play the Astros, Rockies, and Dodgers next. The Seattle Mariners are batting .244 on the season, have a .321 OBP, and a .419 slugging percentage. The Seattle Mariners pitching staff has a 3.92 ERA and a 1.24 WHIP. Julio Rodriguez leads the Seattle Mariners with 167 hits and 93 RBI, while J.P. Crawford and Randy Arozarena have combined for 279 hits and 125 RBI.

Bryce Miller gets the ball for the Seattle Mariners, and he is 4-5 with a 5.59 ERA and 64 strikeouts this season. Miller is 0-0 with a 10.00 ERA and 7 strikeouts in his career against the Kansas City Royals.

Kansas City Royals Betting Preview

The Kansas City Royals are 75-76 on the year and play the Blue Jays, Angels, and Athletics next. The Kansas City Royals are batting .244 on the season, have a .305 OBP, and a .391 slugging percentage. The Kansas City Royals pitching staff has a 3.78 ERA and a 1.26 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 167 hits and 79 RBI while Maikel Garcia and Vinnie Pasquantino have combined for 311 hits and 174 RBI.

Cole Ragans gets the ball for the Kansas City Royals, and he is 2-3 with a 5.18 ERA and 76 strikeouts this season. Ragans is 0-0 with a 1.29 ERA and 11 strikeouts in his career against the Seattle Mariners.

Seattle Mariners @ Kansas City Royals Betting Trends: September 17, 2025

• Probable Starting Pitcher: Cole Ragans      Record this season: 2-3      ERA: 5.18
• Home Record: 1-2
• Last 5 against Mariners: 0-0

Why the Kansas City Royals will win

• The home team has won seven of the Mariners’ last eight games.
• The Mariners have lost each of their last five road games against American League opponents following a road win.
• The Mariners have failed to cover the run line in each of their last nine Wednesday road games.
• The Royals have covered the run line in four of their last five games against the Mariners following a loss.
• The Mariners have trailed after 3 innings in four of their last five games as road underdogs.
• The Mariners have trailed after 5 innings in five of their last six games as road underdogs.

• Probable Starting Pitcher: Bryce Miller      Record this season: 4-5      ERA: 5.59
• Road Record: 2-3
• Last 5 against Royals: 0-0

Why the Seattle Mariners will win

• The Mariners have won each of their last nine games after playing the previous day.
• The Royals have lost 10 of their last 11 games at Kauffman Stadium against American League opponents that held a winning record.
• The Royals have failed to cover the run line in each of their last seven games as favorites.
• The Mariners have covered the run line in each of their last four games as underdogs against American League opponents.
• The Royals have trailed after 5 innings in six of their last seven games at Kauffman Stadium against American League opponents that held a winning record.
• The Royals have trailed after 3 innings in three of their last four games against opponents that held a winning record.
• The Mariners have won the first inning in each of their last three games against American League opponents.

Total Runs Facts

• Each of the Royals’ last seven games as favorites have gone UNDER the total runs line.
• Each of the Mariners’ last five road games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Royals’ last eight night games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last four games at Kauffman Stadium.

Kansas City Royals Player Prop Facts

• Vinnie Pasquantino has hit a home run in four of the Royals’ last six games as home favorites against AL West opponents.
• Bobby Witt Jr. has recorded at least one hit in each of the Royals’ last 10 night games against AL West opponents that held a winning record.

Seattle Mariners Player Prop Facts

• Bryce Miller has recorded six or more strikeouts in five of his last six appearances against AL Central opponents that held a losing record.
• Jorge Polanco has hit a home run in four of the Mariners’ last five games as underdogs against AL opponents.
• Jorge Polanco has recorded at least one hit in each of the Mariners’ last 11 night games.
• Jorge Polanco has recorded at least one Double in each of the Mariners’ last six night games against opponents that held a losing record.

Seattle Mariners vs Kansas City Royals Prediction

The Royals pitching staff continues to get rocked, and now they’re throwing out Ragans who has an ERA over 5 and a 1.29 WHIP. Ragans also hasn’t pitched since June as he’s been dealing with a shoulder injury. Miller has had issues himself this season, but the Mariners have won 10 straight games and make a push for the AL West crown. We’ve been blindly backing the M’s during this stretch, and there’s no reason to turn back now. Give me the Mariners to keep things rolling.