Seattle Mariners vs Houston Astros Prediction 5/13/2026 Today’s MLB Picks

The Seattle Mariners and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s a Seattle Mariners vs. Houston Astros Prediction. This article will include a Seattle Mariners vs. Houston Astros Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 21-22 on the year and play the White Sox and Padres next. The Seattle Mariners are batting. 231 on the season, have a .320 OBP, and have a .380 slugging percentage. The Seattle Mariners’ pitching staff has a 3.67 ERA and a 1.22 WHIP. Randy Arozarena leads the Seattle Mariners with 47 hits and 16 RBI while Josh Naylor and Julio Rodriguez have combined for 85 hits and 39 RBI.

Bryce Miller gets the ball for the Seattle Mariners, and he was 4-6 with a 5.68 ERA and 74 strikeouts last season. Miller is 4-1 with a 2.55 ERA and 25 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 16-27 on the year and play the Rangers and Twins next. The Houston Astros are batting. 255 on the season, have a .330 OBP, and have a .421 slugging percentage. The Houston Astros’ pitching staff has a 5.61 ERA and a 1.59 WHIP. Yordan Alvarez leads the Houston Astros with 49 hits and 29 RBI while Jose Altuve and Christian Walker have combined for 82 hits and 37 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 2-3 with a 7.41 ERA and 37 strikeouts this season. McCullers is 10-3 with a 3.46 ERA and 133 strikeouts in his career against the Seattle Mariners.

Why the Houston Astros will win

• The Astros have won three of their last four games as underdogs following a home loss.
• The Mariners have lost each of their last seven Wednesday night road games.
• The Mariners have failed to cover the run line in 10 of their last 12 night games following a win.
• The Astros have covered the run line in seven of their last eight Wednesday games at Daikin Park.

Why the Seattle Mariners will win

• The Astros have lost each of their last eight night games against the Mariners following a loss.
• The Mariners have won each of their last nine games as favorites against the Astros.
• The Astros have failed to cover the run line in each of their last seven night games against American League opponents.
• The Mariners have covered the run line in eight of their last nine games as favorites against the Astros.
• The Astros have trailed after 5 innings in each of their last six night games against American League opponents.
• The Astros have trailed after 3 innings in three of their last four games against AL West opponents.

Total Runs Facts

• Ten of the Astros’ last 12 games as home underdogs have gone OVER the total runs line.
• Four of the Mariners’ last five road games against AL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of Lance McCullers Jr.’s last eight appearances as a starter.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Mariners’ last 12 games as favorites against AL West opponents.

Houston Astros Player Prop Facts

• Lance McCullers Jr. has recorded six or more strikeouts in each of his last five appearances against the Mariners at Daikin Park.
• Jose Altuve has recorded at least one hit in each of his last 10 Wednesday appearances against teams that held a losing record.
• Jeremy Peña has hit a home run in two of his last three appearances with the Astros as home underdogs against AL West opponents.
• Yordan Alvarez ranks T5th in the league in Home Runs (13) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in three of the Mariners’ last five games as favorites against AL West opponents.
• Bryce Miller has recorded five or more strikeouts in 10 of his 12 previous appearances in night games against AL teams that held a losing record.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 11 Wednesday games against opponents that held a losing record.

Matchup/League Facts

• The Astros rank 30th in the league for runs allowed this season (243).
• The Astros rank 2nd in the league for hits this season (373).
• The Mariners rank T26th in the league for doubles this season (56).
• The Mariners are one of only five teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Seattle Mariners vs Houston Astros Prediction

I’m not excited to get behind Miller, who will make his season debut after dealing with an oblique injury. However, the Astros’ pitching remains god awful and that includes McCullers, who has a 7.41 ERA and 1.50 WHIP through 34 innings. In 19.2 frames at home, McCullers has a 7.32 ERA and .257 allowed batting average. McCullers has allowed 3 or more earned runs in each of his last 6 starts. Miller can’t be worse than that. Give me the M’s on the road.

Randy Chambers's Pick: Seattle Mariners