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San Francisco Giants vs Washington Nationals Prediction 5/25/25 MLB Picks

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Washington Nationals (24-28) vs San Francisco Giants (30-22)

May 25, 2025 at 01:35 PM EDT

The Line: Betting Odds: Washington Nationals +136 / San Francisco Giants -162 — Over/Under: 8

(Get latest betting odds)

The San Francisco Giants and Washington Nationals meet Sunday in MLB action at Nationals Park. Here’s a San Francisco Giants vs Washington Nationals Prediction. This article will include a San Francisco Giants vs Washington Nationals Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 30-22 on the year and play the Tigers, Marlins, and Padres next. The San Francisco Giants are batting .234 on the season, have a .311 OBP, and a .380 slugging percentage. The San Francisco Giants’ pitching staff has a 3.27 ERA and a 1.22 WHIP. Jung Hoo Lee leads the San Francisco Giants with 56 hits and 31 RBI, while Heliot Ramos and Wilmer Flores have combined for 102 hits and 69 RBI. 

Robbie Ray gets the ball for the San Francisco Giants, and he is 6-0 with a 2.67 ERA and 62 strikeouts this season. Ray is 2-5 with a 5.75 ERA and 45 strikeouts in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 24-28 on the year and play the Mariners, Diamondbacks, and Cubs next. The Washington Nationals are batting .242 on the season, have a .311 OBP, and a .389 slugging percentage. The Washington Nationals’ pitching staff has a 5.11 ERA and a 1.42 WHIP. James Wood leads the Washington Nationals with 56 hits and 35 RBI, while Keibert Ruiz and CJ Abrams have combined for 95 hits and 39 RBI.

Michael Soroka gets the ball for the Washington Nationals, and he is 1-2 with a 5.95 ERA and 23 strikeouts this season. Soroka is 1-1 with a 3.75 ERA and 10 strikeouts in his career against the San Francisco Giants.

Why the Washington Nationals will win

  • The Nationals have won each of their last six games as underdogs.
  • The Giants have lost five of their last six games as road favorites.
  • The Nationals have covered the run line in each of their last seven games as underdogs against NL West opponents.
  • The Giants have failed to cover the run line in each of their last six games as favorites.
  • The Giants have trailed after 5 innings in each of their last four games as road favorites.
  • The Giants have trailed after 3 innings in five of their last six games as road favorites.
  • The Giants have lost the first inning in each of their last three games as road favorites against National League opponents.

Why the San Francisco Giants will win

  • The Giants have won each of their last five games against NL East opponents following a road loss.
  • The Nationals have lost five of their last six home games after playing the previous day.
  • The Giants have covered the run line in each of their last nine Sunday day road games.
  • The Nationals have failed to cover the run line in five of their last six games following a home win.
  • The Nationals have trailed after 5 innings in 13 of their last 17 games as underdogs against National League opponents.

Washington Nationals Player Prop Facts

  • Amed Rosario has recorded a Double in three of his last four appearances against opponents that held a winning record.
  • Luis Garcia has recorded at least one RBI in four of the Nationals’ last five games as underdogs.
  • Amed Rosario has scored a run in four of his last five appearances against the Giants.
  • Amed Rosario has recorded at least one Single in seven of his last eight appearances with the Nationals as underdogs.
  • Luis Garcia has recorded at least one hit in 12 of his last 13 appearances against NL West opponents.
  • Paul DeJong has hit a home run in each of his last two appearances with his team as an underdog against the Giants.

San Francisco Giants Player Prop Facts

  • Willy Adames has hit a home run in two of the Giants’ last three games as road favorites against NL opponents.
  • Heliot Ramos has recorded two or more RBIs in four of the Giants’ last five day games.
  • Mike Yastrzemski has scored at least one run in five of his last six appearances in day games against NL teams that held a losing record.
  • Jung Hoo Lee has recorded at least one Single in 12 of his 13 previous road appearances against NL East opponents.
  • Heliot Ramos has recorded at least one hit in nine of his last 10 road appearances against NL East opponents.
  • Patrick Bailey has recorded a Double in three of the Giants’ last four day games against NL opponents that held a losing record.

San Francisco Giants vs Washington Nationals Prediction

The Nationals continue to do just enough winning to give a look in the underdog role, and we hit on them yesterday. I’m going Giants in this spot, however, as Ray has found his form this season, and that includes allowing 18 hits and four runs in his last 26 innings. Soroka has been hittable all season, allowing 21 hits and 13 runs in 19.2 innings. In five home innings, Soroka has a 7.20 ERA and a .263 allowed batting average. Clear pitching edge for the Giants, who are the better team overall. Give me the Giants and the RL for max betting value.

Randy Chambers's Pick: San Francisco Giants -1.5

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