Seattle Mariners vs Houston Astros Prediction 5/25/25 MLB Picks

The Seattle Mariners and the Houston Astros meet Sunday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Houston Astros prediction.

Starting Pitching Matchup

The Seattle Mariners will send out Luis Castillo for the start here, and Castillo is 4-3 with a 3.20 ERA and 44 strikeouts this season. In his last five starts against the Astros, Castillo is 1-2 with a 2.90 ERA and 26 strikeouts. Colton Gordon will start this one for Houston and is 0-0 with a 5.59 ERA and 10 strikeouts this season. This will be Gordon’s first career start against Seattle.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from a 2-1 loss at the hands of the Astros in Saturday’s matchup to fall to 29-22 on the year. After this series, the Mariners will head home for a series against the Washington Nationals.

Mariners Alternate Wins & Losses In 6 Straight Games

Jorge Polanco has 37 hits, including 10 home runs and 30 RBIs, while Cal Raleigh has 47 hits with 10 doubles, a team-high 17 home runs, and 35 RBIs. Randy Arozarena has 41 hits with 11 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 46 hits with a pair of triples, 9 home runs, 29 RBIs, and 6 stolen bases. Dylan Moore has 8 homers and 8 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 23 RBIs, while J.P. Crawford has 45 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

• The Astros have lost each of their last nine day games following a win.
• The Mariners have won each of their last six games against the Astros following a loss.
• The Astros have failed to cover the run line in each of their last nine day games following a win.
• The Mariners have covered the run line in each of their last six games at Daikin Park following a road loss.

Seattle Mariners Player Prop Facts

• Luis Castillo has recorded five or more strikeouts in 18 of his last 19 Sunday appearances with his team as a favorite.
• Victor Robles has recorded a Double in three of his last four appearances against the Astros.
• Victor Robles has recorded at least one hit in each of his last 10 appearances in day games.
• Victor Robles has recorded two Singles in each of his last four appearances against opponents that held a winning record.
• Victor Robles has scored at least one run in each of his last six appearances with the Mariners as road favorites.
• Rowdy Tellez has hit a home run in three of his last four appearances in day games against AL teams that held a winning record.
• Rowdy Tellez has recorded at least one RBI in each of his last five appearances with the Mariners as favorites against AL West opponents.
• Cal Raleigh ranks T3rd in the league in Home Runs (17) this season.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their win over the Mariners from Saturday’s clash to improve their record to 27-25 on the year. After this series, the Astros will square off in a division series against the Athletics.

Astros Looking For Consistency

Jose Altuve has 50 hits, including 6 home runs and 18 RBIs. Jeremy Pena also has 58 hits with 6 homers and 25 RBIs with 6 stolen bases, while Yordan Alvarez has 4 doubles and 18 RBIs with 21 strikeouts as well. Jake Meyers has 7 doubles as well, and Christian Walker has also accrued a team-high 57 strikeouts so far this season. Altuve also has 4 stolen bases while Jake Meyers has a team-high 8 stolen bases this season. Isaac Paredes also has a team-high 11 home runs with 31 RBIs of his own, and Cam Smith has contributed 3 homers and 13 RBIs.

Why the Houston Astros will win

• The underdogs have won each of the last five games between the Mariners and Astros.
• The Mariners have lost six of their last eight games as favorites.
• The underdogs have covered the run line in each of the Astros’ last seven games.
• The Mariners have failed to cover the run line in 10 of their last 11 games as favorites.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in four of the Astros’ last six home games against AL West opponents.
• Isaac Paredes has recorded at least one RBI in five of the Astros’ last six home games against AL West opponents.
• Jose Altuve has scored at least one run in each of his last four appearances with the Astros as home underdogs against AL opponents.
• Jake Meyers has recorded at least one Single in each of the Astros’ last nine games.
• Jose Altuve has recorded at least one hit in each of his last 14 appearances with the Astros as underdogs against the Mariners.

Total Runs Facts

• Seven of the Mariners’ last eight day games as favorites have gone OVER the total runs line.
• Ten of the Astros’ last 12 games as underdogs have gone UNDER the total runs line.

Seattle Mariners vs. Houston Astros Prediction

I’m leaning towards the Mariners here. I just haven’t loved what I’ve seen from Gordon up to this point, and I think the Mariners can get one more win in Houston to close out the series. The Mariners have a significant edge in starting pitching and have been able to do some damage at the plate as well, and I think they do enough against Gordon to get the win and split in the series.