Guardians vs Tigers Prediction 5/25/25 MLB Picks

In this article, we will formulate a Guardians vs Tigers prediction for this MLB game on Sunday, May 25th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 29-22 this year after they won the first three games in this series by scores of 7-0, 3-1, and 7-5. In their game three win, Cleveland trailed 3-0 after the first inning, but they scored the next seven runs in the game for the win in extras. The Guardians recorded 11 hits in the game, and they were led by Martinez and Naylor, who both had two RBIs in the win. Cleveland started Ortiz, who allowed four hits and three earned runs over 5.0 innings, while Herrin picked up the win in relief. 

Prior to this series, the Guardians split two games with the Twins and lost all three against the Reds. Cleveland has won four games in a row, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.96 ERA with a 1.38 WHIP and a .254 opponent batting average, while the offense has scored 209 runs with a .234 batting average and a .307 on-base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 27 RBIs, while Jose Ramirez has added nine home runs and 26 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 2-2 with a 3.86 ERA and a 1.53 WHIP over 44.1 innings pitched this year. 

Detroit Tigers Betting Preview

The Detroit Tigers are 33-20 this season after they lost game three in this series by a score of 7-5. Detroit scored three runs in the first inning, but they didn’t score again until the 10th, where they came up short for the loss. The Tigers recorded five hits and they committed one error in the game, while they were led by Vierling and Torres, who both had two RBIs in the loss. Detroit started Mize, who allowed four hits and one earned run over 5.0 innings, while Kahnle blew the save and Hanifee was tagged with the loss. 

Prior to this series, the Tigers won two out of three against the Cardinals and two out of three against the Blue Jays. Detroit has lost four of its last six games, and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.38 ERA with a 1.18 WHIP and a .228 opponent batting average, while the offense has scored 273 runs with a .253 batting average and a .326 on-base percentage this season. Spencer Torkelson has led Detroit with 13 home runs and 40 RBIs, while Riley Greene has added 12 home runs and 34 RBIs this year. The projected starting pitcher for Detroit is Tarik Skubal, who is 4-2 with a 2.87 ERA and a 0.94 WHIP over 59.2 innings pitched this season. 

Why the Tigers will beat the Guardians 

• The Tigers have won each of their last four day games after going to extra innings.
• The Guardians have lost each of their last six Sunday games against teams that held a winning record.
• The Tigers have covered the run line in nine of their last 10 day games against teams that held a winning record.
• The Guardians have failed to cover the run line in four of their last five day games at Comerica Park following a win.
• The Guardians have trailed after 3 innings in five of their last six day games against American League opponents that held a winning record.
• The Tigers have led after 5 innings in nine of their last 11 day games.

Total Runs Facts

• Four of the Tigers’ last five day games against AL Central opponents have gone UNDER the total runs line.
• Four of the Guardians’ last five games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Tigers’ last six home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Guardians’ last 10 games at Comerica Park.

Detroit Tigers Player Prop Facts

• Colt Keith has recorded a Double in three of the Tigers’ last four games against AL opponents at Comerica Park.
• Gleyber Torres has scored at least one run in six of his last eight home appearances against AL Central opponents that held a winning record.
• Tarik Skubal has recorded a win in four of his last five appearances at Comerica Park against opponents that held a winning record.
• Tarik Skubal has recorded eight or more strikeouts in each of his last five appearances with the Tigers as favorites.
• Spencer Torkelson has hit a home run in four of the Tigers’ last nine games against AL Central opponents.
• Zach McKinstry has recorded at least one RBI in each of the Tigers’ last three day games against AL teams that held a winning record.
• Gleyber Torres has recorded at least one hit in each of his last nine appearances in day games against AL Central teams that held a winning record.
• Zach McKinstry has recorded a Single in each of the Tigers’ last four day games against AL opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in each of the Guardians’ last two day games against opponents that held a winning record.
• Carlos Santana has recorded at least one RBI in five of the Guardians’ last six games against AL opponents.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 16 games against AL opponents that held a winning record.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last 10 games against AL Central opponents that held a winning record.
• Steven Kwan has recorded at least one Double in three of the Guardians’ last four day games against opponents that held a winning record.
• Jose Ramirez has scored at least one run in each of the Guardians’ last seven games as underdogs against AL Central opponents.

Guardians vs Tigers Prediction 

Detroit comes into this matchup trying to avoid a four-game sweep, but they need to find more offense, as they have been pretty bad at the plate in the series. The Tigers are 17-8 at home this year, while the Guardians are 15-14 on the road. Cleveland has won four games in a row, and they are just three games back in the AL Central race. The Guardians are starting Allen, who has allowed two earned runs or fewer in three of his last four starts, but only pitched three innings last time out. Detroit is going with Skubal, who has been very good this year, but has allowed eight earned runs over his last two starts. I am going to side with Detroit on the run line here, but Skubal’s last two outings are definitely a concern.