San Francisco Giants vs St. Louis Cardinals Prediction 9/5/2025 Today’s MLB Picks

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB game on Friday, September 5th at the Busch Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 70-71 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 39-33 home record and are 71-62 in over/under. They are coming off a 5-1 home victory over the A’s, and have back-to-back wins. Over is 7-5-1 in their last 13 games and are playing the Brewers and the Mariners next.

The Cardinals have a .247 batting average this season, .315 OBP and .384 Slugging percentage. Saint Louis’ pitching staff has a 4.25 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 6-2 record, 4.17 ERA and 1.19 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 71-69 record this season and are sitting on the third place of the NL West. They have a 36-35 road record and are 66-68 in over/under. They are coming off a 10-8 road victory over the Rockies, and are 10-1 in their last 11 games. Over is 5-1 in their last 6 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .238 batting average this season, .313 OBP and .389 Slugging percentage. San Francisco’s pitching staff has a 3.78 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 143 hits and is the team’s best hitter, with a .268 batting average. Willy Adames leads the team in RBI with 76, adding a team-high 26 home runs. 

Reliever Carson Seymour (R) is the projected starting pitcher for the Giants, and he has a 0-2 record, 4.74 ERA and 1.50 WHIP.

Giants vs Cardinals Prediction

The Cardinals are 5-1 in their last 6 head-to-head meetings against the Giants, and have won their last three meetings in Saint Louis. Over is 7-1 in their last 8 meetings.

In this Giants vs Cardinals Prediction, the Cardinals are coming as -120 home favorites. Both teams are playing good baseball, but I cannot trust the Giants on the road in a bullpen game. McGreevy has been in good form for the Cardinals lately, as he has a 4-1 record and a 3.00 ERA across his last five starts, and the Cardinals are playing their second straight series at home, while the Giants their second straight on the road, having to travel from the altitude of Colorado. Take the Saint Louis Cardinals to take care of business at home in this one.