San Francisco Giants vs Houston Astros Prediction 3/31/25 MLB Picks

In this article, we will formulate a San Francisco Giants vs Houston Astros prediction for this MLB game on Monday, March 31st, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 2-1 this year after they won two out of three games against the Reds over the weekend. San Francisco won games one and three by scores of 6-4 and 6-3, but did drop game two by a score of 3-2. In game three on Sunday, the Giants were held scoreless in the first four innings, but they scored six runs between the fifth and eighth inning for the win. Chapman and Ramos had two RBIs each, while Robbie Ray allowed three earned runs and three hits over 5.1 innings of work. 

The San Francisco pitching staff has a 3.46 ERA with a 1.08 WHIP and a .221 opponent batting average, while their offense has scored 14 runs with a .214 batting average and a .250 on-base percentage this year. Flores and Ramos both have two home runs this season, and they also lead the team with four RBIs each. The projected starting pitcher for San Francisco is Jordan Hicks, who went 4-7 with a 4.10 ERA and a 1.45 WHIP over 109.2 innings pitched in 2024. 

Houston Astros Betting Preview

The Houston Astros are 2-1 this season after they won two out of three against the Mets in their first series. Houston won games one and three by scores of 3-1 and 2-1, but did lose game two by a score of 3-1. In game three, Houston homered in the fifth inning and got the winning run on an Alvarez double in the sixth, while holding New York to just one hit in the game. Alvarez and Pena both had one RBI in the game, while Arrighetti allowed one earned run and one hit over 6.0 innings, while also striking out five. 

The Houston pitching staff has a 1.33 ERA with a 0.93 WHIP and a .136 opponent batting average, while the offense has scored six runs with a .176 batting average and a .290 on-base percentage. Jeremy Pena is the only Astro with a home run so far this year, while Yordan Alvarez has two RBIs through three games. The projected starting pitcher for Houston is Ronel Blanco, who was 13-6 with a 2.80 ERA and a 1.09 WHIP over 167.1 innings pitched last season. 

Why the Astros will beat the Giants 

• The Giants have lost each of their last six night games against the Astros following a win.
• The Astros have won four of their last five night games against teams that held a winning record.
• The Giants have failed to cover the run line each of their last four games against teams that held a winning record.

Total Runs Facts

• Each of the Astros’ last six games against National League opponents have gone UNDER the total runs line.
• Four of the Giants’ last five games as underdogs against the Astros have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last 11 games as home favorites against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four night games against American League opponents.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in five of his last nine appearances in night games against NL West teams that held a winning record.
• Yainer Diaz has recorded at least one RBI in four of the Astros’ last five home games against NL West opponents.
• Isaac Paredes has recorded at least one Single in each of his last seven appearances against NL West opponents that held a winning record.
• Jose Altuve has scored at least one run in each of the Astros’ last four games against NL West opponents at Daikin Park.
• Jose Altuve has recorded at least one Double in each of the Astros’ last four games as favorites against NL West opponents.
• Jose Altuve has recorded at least one hit in each of the Astros’ last 11 home games against NL West opponents.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded at least one Single in seven of his last eight appearances with the Giants as underdogs.
• Mike Yastrzemski has scored at least one run in seven of his last eight appearances against AL West opponents that held a winning record.
• Willy Adames has recorded at least one hit in each of his last 10 road appearances against AL opponents that held a winning record.
• Heliot Ramos has hit a home run in three of the Giants’ last four road games against AL West opponents.
• Willy Adames has recorded at least one RBI in each of his last four road appearances against AL West opponents that held a winning record.

San Francisco Giants vs Houston Astros Prediction 

Both of these teams come into this matchup with 2-1 records after the first series of the season, but Houston will be looking for more offense. The Astros scored just six runs through three games, but on the bright side, their pitching staff was great. The Giants exploded for 12 total runs in their two victories, and they hit three home runs. The Astros will start Blanco, who had a very good 2024 season, and I think this is a very good matchup for him. San Francisco is starting Jordan Hicks, who had an elevated WHIP last season, but might be able to take advantage of the slow Houston start. Blanco is the better option, in my opinion, and even with the bad offense, I will take Houston here.