Philadelphia Phillies vs Chicago Cubs Prediction 4/22/2026 Today’s MLB Picks

In this article, we will formulate a Phillies vs Cubs Prediction for this MLB matchup on Wednesday, April 22nd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 14-9 record this season and are sitting in the second place of the NL Central. They have a 9-5 home record and are coming off a 7-4 home win against the Phillies. Their previous three games were a 5-1 home win against the Phillies, and a 2-1 and a 4-2 home win against the Mets.

The Cubs have a .255 batting average this season, .350 OBP and .404 Slugging percentage. Chicago’s pitching staff has a 3.45 ERA and 1.15 WHIP. Nico Hoerner is the team’s best hitter with a .326 batting average, also leading the team in RBI with 22. Ian Happ adds a team‑high 6 home runs.

Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has a 1-1 record, 6.75 ERA and 1.18 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 8-15 record this season and are sitting in the fourth place of the NL East. They have a 3-5 away record and are coming off a 4-7 road loss against the Cubs. Their previous three games were a 1-5 road loss against the Cubs, and a 2-4 and a 1-3 home loss against the Braves.

The Phillies have a .218 batting average this season, .298 OBP and .360 Slugging percentage. Philadelphia’s pitching staff has a 4.99 ERA and 1.47 WHIP. Brandon Marsh is the team’s best hitter with a .276 batting average. Kyle Schwarber leads the team in RBI with 15, also adding a team‑high 8 home runs.

Kyle Backhus (L) is the projected starting pitcher for the Phillies, and he has a 0-0 record, 5.40 ERA and 1.20 WHIP.

Philadelphia Phillies @ the Chicago Cubs Betting Trends: April 22, 2026

• Probable Starting Pitcher: Matthew Boyd      Record this season: 1-1      ERA: 6.75
• Home Record: 1-1
• Last 5 against Phillies: 0-0

Why the Chicago Cubs will win

• The Cubs have won each of their last eight home games against National League opponents that held a losing record.
• The Phillies have lost each of their last seven games.
• The Phillies have failed to cover the run line each of their last 11 games against teams that held a winning record.
• The Cubs have covered the run line in seven of their last eight home games against National League opponents that held a losing record.
• The Cubs have led after 3 innings in each of their last five Wednesday games as home favorites.
• The Phillies have trailed after 5 innings in each of their last six games.

• Probable Starting Pitcher: Kyle Backhus      Record this season: 0-0      ERA: 5.40
• Road Record: 0-0
• Last 5 against Cubs: 0-0

Why the Philadelphia Phillies will win

• The Phillies have won three of their last four games as underdogs following a road loss.
• The Cubs have lost three of their last four Wednesday night games as favorites against NL East opponents.
• The Phillies have covered the run line in 10 of their last 12 games as underdogs following a road loss.
• The Cubs have failed to cover the run line in 15 of their last 20 home games against NL East opponents following a home win.

Total Runs Facts

• Seven of the Cubs’ last eight night games against NL East opponents have gone OVER the total runs line.
• Four of the Phillies’ last five games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Phillies’ last eight games at Wrigley Field.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five games between the Phillies and Cubs at Wrigley Field.

Chicago Cubs Player Prop Facts

• Matthew Boyd has recorded six or more strikeouts in each of his last six Wednesday night appearances against teams that held a losing record.
• Matthew Boyd has recorded a win in six of his last eight home appearances against opponents that held a losing record.
• Dansby Swanson has hit a home run in three of the Cubs’ last four night games against opponents that held a losing record.
• Ian Happ has recorded at least one hit in each of the Cubs’ last 12 home games against NL East opponents.

Philadelphia Phillies Player Prop Facts

• Kyle Schwarber has hit a home run in two of the Phillies’ last three games.
• Bryson Stott has recorded a hit in each of his last seven appearances.
• Kyle Schwarber ranks T4th in the league in Home Runs (8) this season.

Matchup/League Facts

• The Cubs rank 3rd in the league for on-base percentage this season (.350).
• The Cubs rank 3rd in the league for walks allowed this season (69).
• The Phillies rank 30th in the league for opponent batting average this season (.278).
• The Phillies rank 29th in the league for hits allowed this season (226).

Phillies vs Cubs Prediction

The Cubs have won their last four meetings against the Phillies, but both teams are tied 2-2 in their last 4 meetings in Chicago.

In this Phillies vs Cubs Prediction, the Cubs are coming as -170 home favorites. Both teams are coming in opposite trajectories, as the red-hot Cubs, winners of seven straight, are facing the struggling Phillies, who have seven consecutive losses. The Phillies are going for a bullpen game but they rank 20th in bullpen ERA, while the Cubs are 11th. Boyd takes the mound for the Cubs in his return from an injury and he is coming off a quality start and the Phillies are weaker against lefties. Chicago also has the 5th-best offense in baseball, so keep it simple and take the Cubs once again to win.

Nikos Lagouretos's Pick: Chicago Cubs ML