Minnesota Twins vs Chicago White Sox Prediction 4/2/25 MLB Picks

The Minnesota Twins and Chicago White Sox meet on Wednesday in MLB action at Rate Field. Here’s a Minnesota Twins vs Chicago White Sox Prediction. This article will include a Minnesota Twins vs Chicago White Sox Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 1-4 on the year and play the Astros, Royals, and Tigers next. The Minnesota Twins are batting .174 on the season, have a .253 OBP, and a .267 slugging percentage. The Minnesota Twins’ pitching staff has a 6.37 ERA and a 1.59 WHIP. Willi Castro leads the Minnesota Twins with 5 hits and 3 RBI, while Ryan Jeffers and Trevor Larnach have combined for 8 hits and 1 RBI. 

Pablo Lopez gets the ball for the Minnesota Twins, and he is 0-1 with a 3.60 ERA and 3 strikeouts this season. Lopez is 0-1 with a 4.40 ERA and 37 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 2-3 on the year and play the Tigers, Guardians, and Red Sox next. The Chicago White Sox are batting .222 on the season, have a .282 OBP, and a .405 slugging percentage. The Chicago White Sox pitching staff has a 2.20 ERA and a 1.09 WHIP. Andrew Benintendi leads the Chicago White Sox with 6 hits and 6 RBI, while Lenyn Sosa and Brooks Baldwin have combined for 8 hits and 4 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 1-0 with a 0.00 ERA and 3 strikeouts this season. This will be Burke’s first career game against the Minnesota Twins.

Why the Chicago White Sox will win

• The Twins have lost each of their last four games as favorites following a win.
• The White Sox have won three of their last four games as underdogs following a loss.
• The White Sox have covered the run line each of their last six day games against teams that held a losing record.
• The Twins have failed to cover the run line in nine of their last 10 day games against American League opponents.
• The White Sox have won the first inning in three of their last four home games against AL Central opponents that held a losing record.
• The Twins have trailed after 3 innings in five of their last six road day games.
• The White Sox have led after 5 innings in each of their last four day games against the Twins at Rate Field.

Why the Minnesota Twins will win

• The White Sox have lost 11 of their last 12 day games following a home loss.
• The Twins have won 10 of their last 11 games against the White Sox following a win.
• The White Sox have failed to cover the run line in nine of their last 10 home games against AL Central opponents.
• The Twins have covered the run line in four of their last five games against AL Central opponents that held a losing record.

Minnesota Twins vs Chicago White Sox Prediction

The Twins are getting the benefit of the doubt because they’re the better team on paper, and they’re throwing out an all-star caliber pitcher in Lopez. The Twins should win this game. However, outside of last night, the Twins have been awful across the board. The Twins aren’t hitting the ball, and their pitching staff has been bottom-five in all of baseball through five games. Burke has also been great through four career starts, allowing 15 hits and three earned runs in 25 innings while striking out 15. It’s a small sample size, but the White Sox have something there. I’ll take a stab with the White Sox and the big plus money.