San Francisco Giants vs Houston Astros Prediction 4/2/25 MLB Picks

The projected starting pitcher for the Giants is Lander Roupp, who had a 1-2 record in four starts last season with a 3.58 ERA and 1.37 WHIP over 50.1 innings of work. Lopez took a loss against the Cards this year and posted a 3.60 ERA in 5.0 innings.

Houston Astros Betting Preview

The Houston Astros (2-3, 2-3 Home) beat the New York Mets 2-1 in a three-game series to start the season. All three games were low-scoring, as the teams failed to combine for more than four runs. The Astros then lost a pair of games to the Giants, allowing ten and scoring just three runs in the process. In a most recent 3-1 defeat, Jose Altuve scored a solo homer, while Hayden Wesneski took a loss after allowing three runs on two hits, with six strikeouts and three walks in 5.0 innings.

This year, the Astros average 2.00 runs per game (28th in the MLB) on a .157/.269/.200 triple-slash. When it comes to pitching, the Astros’ staff has a 2.75 ERA (7th) and 1.08 WHIP (7th). Jose Altuve leads the Astros with a .389 batting average, one home run, and one RBI this season.

Framber Valdez will take the mound for the Astros on Wednesday. The 31-year-old southpaw had a 15-7 record last season in 28 starts with a 2.91 ERA and 1.11 WHIP in 176.1 innings. This season, Valdez started with a win in a shutout of the Mets when he allowed four hits with four strikeouts and two walks over 7.0 innings of work.

Why the Astros will beat the Giants

• The Astros have won four of their last five games against National League opponents following a loss.
• The Giants have lost each of their last three day games against AL West opponents following a win.
• The Astros have covered the run line in five of their last six day games against National League opponents following a loss.
• The Giants have failed to cover the run line in three of their last four day games against American League opponents that held a losing record.
• The Giants have trailed after 5 innings in three of their last four games at Daikin Park against AL West opponents that held a losing record.

Total Runs Facts

• Seven of the Astros' last eight games against National League opponents have gone UNDER the total runs line.
• Nine of the Giants' last 12 games as underdogs against American League opponents have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Astros' last 12 games as home favorites against National League opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Giants' last four road games.

Giants vs Astros Prediction

The Giants won eight of the previous ten H2H encounters, including six of the last seven. Landen Roupp is an inexperienced pitcher, and I think he will struggle against the Astros, who still haven't found their offensive rhythm this season. Framber Valdez, on the other hand, had a poor outing against the Giants last year, but he will get a quality start in this one after a strong display against the Mets, who, honestly, have better batters in their lineup than the Giants. Expect the hosts to bounce back and avoid a series sweep.