Milwaukee Brewers vs Chicago Cubs Prediction 8/20/2025 Today’s MLB Picks

In this article, we will formulate a Brewers vs Cubs Prediction for this MLB game on Wednesday, August 20th at the Wrigley Field in the fourth game of this series, with the Cubs having the 2-1 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 72-54 record this season and are sitting on the second place of the NL Central. The Cubs have a 40-24 home record and are 57-58 in over/under. They are coming off a 4-1 home victory over the Brewers, and have back-to-back wins. Under is 8-1-1 in their last 10 games, and are playing the Angels and the Giants next.

The Cubs have a .250 batting average this season, .319 OBP and .429 Slugging percentage. Chicago’s pitching staff has a 3.81 ERA and 1.21 WHIP. Nico Hoerner leads the Cubs with 133 hits, and he is the team’s best hitter with a .291 batting average. Seiya Suzuki leads the team in RBI, with 86, adding a team-high 27 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 9-5 record, 3.99 ERA and 1.28 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 79-47 record this season and are sitting on the first place of the NL Central. They have a 37-27 road record and are 59-64 in over/under. They are coming off a 1-4 road defeat by the Cubs, and have back-to-back losses. Under is 4-1 in their last 5 games, and are playing the Giants and the Diamondbacks next.

The Brewers have a .258 batting average this season, .332 OBP and .406 Slugging percentage. Milwaukee’s pitching staff has a 3.58 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 127 hits, while Christian Yelich leads the team in RBI, with 87, adding a team-high 26 home runs. Sal Frelick is the team’s best hitter with a .298 batting average.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 4-1 record, 3.89 ERA and 1.13 WHIP.

Why the Chicago Cubs will win

• The Cubs have won each of their last eight Wednesday games as underdogs against NL Central opponents.
• The Brewers have lost four of their last five games as favorites against the Cubs following a road loss.
• The Cubs have covered the run line in each of their last 11 Wednesday games as underdogs against NL Central opponents.
• The Brewers have failed to cover the run line in four of their last five games as road favorites against NL Central opponents.
• The Cubs have led after 3 innings in six of their last seven home night games.
• The Cubs have led after 5 innings in seven of their last eight night games at Wrigley Field against National League opponents.

Why the Milwaukee Brewers will win

• The Brewers have won 12 of their last 13 night games against National League opponents.
• The Cubs have lost four of their last five night games following a win.
• The Cubs have failed to cover the run line in 12 of their last 13 games following a win.
• The Brewers have covered the run line in 16 of their last 19 road games.
• The Brewers have led after 3 innings in six of their last eight night games against NL Central opponents.
• The Brewers have led after 5 innings in 15 of their last 19 night games against National League opponents.

Total Runs Facts

• Five of the Cubs’ last six night games after playing the previous day have gone UNDER the total runs line.
• Eight of the Brewers’ last 10 games as favorites against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Brewers’ last seven games as road favorites against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cubs’ last seven games as home underdogs against NL Central opponents.

Matchup/League Facts

• The Cubs rank 1st in the league for walks allowed this season (327).
• The Cubs rank 3rd in the league for steals this season (132).
• The Brewers rank 2nd in the league for runs scored this season (650).
• The Brewers rank 2nd in the league for hits this season (1106).

Brewers vs Cubs Prediction

The Brewers are 5-3 in their last 8 meetings against the Cubs, but both teams are tied 3-3 wins in their last 6 meetings in Chicago. Under is 3-1 in their last 4 meetings.

In this Brewers vs Cubs Prediction, both teams are coming at a pickem price. This is a battle for the first place of the NL Central, and the Cubs managed to win both games of yesterday’s double header. Misiorowski has been struggling lately for the Brewers, with a 6.27 ERA across his last five starts, and has been weaker on the road this season. On the flip side, Rea is coming off back-to-back quality starts, and the Cubs are better against right-handed pitching. This matchup looks like a real coin flip, but at a pickem price, I will lean towards the Chicago Cubs at home in this one.