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Cincinnati Reds vs St. Louis Cardinals Prediction 9/15/2025 Today’s MLB Picks
Pick details
Cincinnati (74-75) vs St. Louis (73-77)
September 15, 2025 at 07:45 PM EDT
The Line: Betting Odds: St. Louis -128 – Cincinnati +104 — Over/Under: 8.5
The Cincinnati Reds and St. Louis Cardinals meet on Monday in MLB action from the Busch Stadium. Here’s a Cincinnati Reds vs St. Louis Cardinals prediction. We will look at this from a betting perspective and determine the best Cardinals vs Reds pick. We will examine:
The Cincinnati Reds’ recent form and player performance
The St. Louis Cardinals recent form and player performance
Recent betting trends and streaks involving the Reds
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between the Reds and Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Reds and Cardinals game.
The Cardinals are averaging 4.28 runs while their pitching is giving up 4.63 runs per game. The offense is ranked 19th while the pitching is ranked 21st. Wilson Contreras has hit 20 home runs and driven in 79 RBIs so far this season. Getting the start for the Cardinals will be Matthew Liberatore who sits with a 7-12 record and an ERA of 4.35. Against the Seattle Mariners in his last start he went four innings giving up six hits and five runs.
Why the Cardinals Will Beat the Reds
The Cardinals have won each of their last eight Monday night home games against NL Central opponents.
The Reds have lost 10 of their last 11 night games against National League opponents that held a losing record.
The Reds have failed to cover the run line in 10 of their last 11 night games against National League opponents that held a losing record.
The home team has covered the run line in each of the Reds’ last three games.
The Cardinals have led after 3 innings in three of their last four night games against the Reds.
The Cardinals have led after 5 innings in four of their last five night games against NL Central opponents.
The Reds are averaging 4.46 runs while their pitching si giving up 4.33 runs per game. The offense is ranked 14th while the pitching is ranked 16th. Elly De La Cruz has hit 19 home runs and driven in 82 RBIs. Getting the start for the Reds will be Zack Littell who sits with a 9-8 record and an ERA of 3.38. Against the San Diego Padres in his last start he went six innings, giving up two hits and two runs.
Why the Reds Will Beat the Cardinals
The Cardinals have lost nine of their last 11 games as favorites against National League opponents following a win.
The underdogs have won four of the Reds’ last five games.
The Cardinals have failed to cover the run line in each of their last 11 games as favorites following a win.
The Reds have covered the run line in each of their last six night games at Busch Stadium following a road loss.
The Cardinals have lost the first inning in three of their last four games as favorites against NL Central opponents.
Give me the Reds to get the job done in this game. The Reds struggled on Sunday with the pitching, but Monday is going to be a much different story. Zack Littell sits with an ERA of 3.38 and in his last start, he gave up only two hits and two runs. The Reds offense might not be elite, but they aren’t going to need to be elite going against Matthew Liberatore who gave up six hits and five runs in his last start. The Reds will score at least three off of him, and that will be enough for Cincinnati to get the job done. Back the Reds on the money line to cash here with ease.
The Cincinnati Reds’ recent form and player performance
The St. Louis Cardinals recent form and player performance
Recent betting trends and streaks involving the Reds
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between the Reds and Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Reds and Cardinals game.
Cardinals Pitching Stepped Up
The Cardinals pitching stepped up in a big way on Sunday against the Milwaukee Brewers. The offense scored three runs, and the pitching gave up only two runs on the way to the win. The Brewers were actually outhit 8-6 but they had some key outs with runners in scoring position that ended up being the difference. Miles Mikolas was on the mound and went five innings giving up two runsThe Cardinals are averaging 4.28 runs while their pitching is giving up 4.63 runs per game. The offense is ranked 19th while the pitching is ranked 21st. Wilson Contreras has hit 20 home runs and driven in 79 RBIs so far this season. Getting the start for the Cardinals will be Matthew Liberatore who sits with a 7-12 record and an ERA of 4.35. Against the Seattle Mariners in his last start he went four innings giving up six hits and five runs.
Why the Cardinals Will Beat the Reds
The Cardinals have won each of their last eight Monday night home games against NL Central opponents.
The Reds have lost 10 of their last 11 night games against National League opponents that held a losing record.
The Reds have failed to cover the run line in 10 of their last 11 night games against National League opponents that held a losing record.
The home team has covered the run line in each of the Reds’ last three games.
The Cardinals have led after 3 innings in three of their last four night games against the Reds.
The Cardinals have led after 5 innings in four of their last five night games against NL Central opponents.
Reds Blowing It
The Reds have all but blown their playoff chances, and Sunday was another loss. The Reds scored four runs, but the pitching gave up seven runs against the A’s and that led to the defeat. Will Benson had a huge game hitting a home run and driving in two RBIs, but it wasn’t even close enough. Nick Lodolo got the start and he had some struggles going 5.1 innings giving up eight hits and five runs.The Reds are averaging 4.46 runs while their pitching si giving up 4.33 runs per game. The offense is ranked 14th while the pitching is ranked 16th. Elly De La Cruz has hit 19 home runs and driven in 82 RBIs. Getting the start for the Reds will be Zack Littell who sits with a 9-8 record and an ERA of 3.38. Against the San Diego Padres in his last start he went six innings, giving up two hits and two runs.
Why the Reds Will Beat the Cardinals
The Cardinals have lost nine of their last 11 games as favorites against National League opponents following a win.
The underdogs have won four of the Reds’ last five games.
The Cardinals have failed to cover the run line in each of their last 11 games as favorites following a win.
The Reds have covered the run line in each of their last six night games at Busch Stadium following a road loss.
The Cardinals have lost the first inning in three of their last four games as favorites against NL Central opponents.
Cincinnati Reds vs St. Louis Cardinals Prediction
Give me the Reds to get the job done in this game. The Reds struggled on Sunday with the pitching, but Monday is going to be a much different story. Zack Littell sits with an ERA of 3.38 and in his last start, he gave up only two hits and two runs. The Reds offense might not be elite, but they aren’t going to need to be elite going against Matthew Liberatore who gave up six hits and five runs in his last start. The Reds will score at least three off of him, and that will be enough for Cincinnati to get the job done. Back the Reds on the money line to cash here with ease.
