Boston Red Sox vs Oakland Athletics Prediction 9/10/2025 Today’s MLB Picks

In this article, we will formulate a Red Sox vs Athletics Prediction for this MLB game on Wednesday, September 10th at the Sutter Health Park in the third game of this series, with the Red Sox having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 66-80 record this season and are sitting on the last place of the AL West. The Athletics have a 29-42 home record and are 73-67 in over/under. They are coming off a 0-6 home defeat by the Red Sox, and have three consecutive losses. Under is 5-2 in their last 7 games and are playing the Red Sox and the Reds next.

The Athletics have a .254 batting average this season, .320 OBP and .433 Slugging percentage. Athletics’ pitching staff has a 4.81 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 151 hits, while Jacob Wilson is the team’s best hitter with a .319 batting average. Tyler Soderstrom adds a team-high 86 RBI, while Shea Langeliers adds a team-high 29 home runs. 

Mason Barnett (R) is the projected starter for the Athletics, and he has a 1-1 record, 9.00 ERA, and 1.78 WHIP. 

Boston Red Sox Preview

The Boston Red Sox have an 81-65 record this season and are sitting on the third place of the AL East. The Red Sox have a 37-37 road record and are 71-72 in over/under. They are coming off a 6-0 road victory over the A’s, and have three consecutive wins. They are 3-1 to the under in their last 4 games and are playing the Athletics and the Yankees next.

The Red Sox have a .254 batting average this season, .324 OBP and .425 slugging percentage. Boston’s pitching staff has a 3.73 ERA and 1.29 WHIP.  Jarren Duran leads the Red Sox with 145 hits, while Trevor Story is the team’s best hitter, with a .263 batting average. He also leads the team in RBI, with 90, adding a team-high 24 home runs.

Payton Tolle (R) is the projected starting pitcher for the Red Sox, and he has a 0-1 record, 7.56 ERA and 1.68 WHIP.

Boston Red Sox @ Athletics Betting Trends: September 10, 2025

• Probable Starting Pitcher: Mason Barnett      Record this season: 1-1      ERA: 9.00
• Home Record: 0-1
• Last 5 against Red Sox: –

Why the Athletics will win

• The underdogs have won seven of the Athletics’ last eight games.
• The Red Sox have lost three of their last four games as favorites.
• The underdogs have covered the run line in seven of the Athletics’ last eight games.
• The Red Sox have failed to cover the run line in four of their last five games as road favorites.
• The Red Sox have trailed after 3 innings in three of their last four games as favorites.
• The Athletics have led after 5 innings in four of their last five day games against AL East opponents that held a winning record.

• Probable Starting Pitcher: Payton Tolle      Record this season: 0-1      ERA: 7.56
• Road Record: 0-1
• Last 5 against Athletics: –

Why the Boston Red Sox will win

• The Red Sox have won each of their last eight road games against American League opponents that held a losing record.
• The Athletics have lost each of their last five home games.
• The Athletics have failed to cover the run line in each of their last five home games.
• The Red Sox have covered the run line in each of their last five day games against AL West opponents following a win.
• The Athletics have trailed after 3 innings in each of their last four home games.
• The Athletics have trailed after 5 innings in each of their last five home games.
• The Red Sox have won the first inning in each of their last four road games against American League opponents.

Total Runs Facts

• Each of the Red Sox’s last six road games against American League opponents have gone UNDER the total runs line.
• Each of the last four games between the Red Sox and Athletics have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last six games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last four road games against American League opponents.

Athletics Player Prop Facts

• Lawrence Butler has recorded at least one hit in seven of his last eight home appearances.
• JJ Bleday has hit at least one home run in each of his last three appearances with the Athletics as underdogs.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.319) this season.

Boston Red Sox Player Prop Facts

• Trevor Story has hit a home run in three of the Red Sox’s last four games as road favorites against AL opponents.
• Trevor Story has recorded at least one Double in five of his last six appearances with the Red Sox as road favorites against the Athletics.
• Connor Wong has recorded at least one hit in each of his last seven appearances in day games against AL teams that held a losing record.

Matchup/League Facts

• The Athletics rank 2nd in the league for doubles this season (267).
• The Athletics rank 29th in the league for home runs allowed this season (205).
• The Red Sox rank 1st in the league for doubles this season (295).
• The Red Sox rank 28th in the league for strikeouts against this season (1286).

Red Sox vs Athletics Prediction

The Red Sox are 7-1 in their last 8 head-to-head meetings against the A’s, having won their last five road meetings. Under is 5-1 in their last 6 meetings.

In this Red Sox vs Athletics Prediction, the Red Sox are coming as -130 road favorites. We have seen little from both of these pitchers, but in their two starts this season, they both looked terrible, having 7 and 9 earned runs each. I will not risk in taking the over again in this matchup, as the A’s have been shutout in both games. Even though I don’t trust Payton Tolle for the Red Sox, they have a superior bullpen and offense to offer support and get away with yet another road victory.