Baltimore Orioles vs Los Angeles Angels Prediction 6/22/2026 Today’s MLB Picks

In this article, we will formulate a Orioles vs Angels Prediction for this MLB matchup on Monday, June 22nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 32-47 record this season and are sitting in the 5th place of the AL West. They have a 17-20 home record and are coming off a 9-7 road win against the Athletics. They will face the Athletics and the Mariners next.

The Angels have a .240 batting average this season, .320 OBP and .401 Slugging percentage. Los Angeles’s pitching staff has a 4.65 ERA and 1.43 WHIP. Nolan Schanuel is the team’s best hitter with a .258 batting average. Jo Adell leads the team in RBI with 41, while Mike Trout adds a team-high 17 home runs.

Sam Aldegheri (L) is the projected starting pitcher for the Angels, and he has a 2-2 record, 4.50 ERA and 1.55 WHIP.

Baltimore Orioles Preview

The Baltimore Orioles have a 37-42 record this season and are sitting in the 4th place of the AL East. They have a 15-23 road record and are coming off a 12-1 road win against the Dodgers. They will face the Nationals and the White Sox next.

The Orioles have a .241 batting average this season, .321 OBP and .403 Slugging percentage. Baltimore’s pitching staff has a 4.45 ERA and 1.39 WHIP. Taylor Ward is the team’s best hitter with a .255 batting average. Pete Alonso leads the team in RBI with 52, adding a team-high 18 home runs.

Kyle Bradish (R) is the projected starting pitcher for the Orioles, and he has a 4-7 record, 4.00 ERA and 1.51 WHIP.

Baltimore Orioles @ Los Angeles Angels Betting Trends: June 22, 2026

• Probable Starting Pitcher: Samuel Aldegheri      Record this season: 2-2      ERA: 4.50
• Home Record: 1-1
• Last 5 against Orioles: –

Why the Los Angeles Angels will win

• The Orioles have lost four of their last five games as favorites against AL West opponents following a win.
• The Angels have won three of their last four games as home underdogs.
• The Orioles have failed to cover the run line in each of their last six games as favorites against AL West opponents following a road win.
• The Angels have covered the run line in 10 of their last 11 games as home underdogs against American League opponents.
• The Angels have won the first inning in three of their last four night games at Angel Stadium of Anaheim.
• The Orioles have trailed after 3 innings in seven of their last eight road games against AL West opponents that held a losing record.
• The Angels have led after 5 innings in each of their last nine night games at Angel Stadium of Anaheim against American League opponents.

• Probable Starting Pitcher: Kyle Bradish      Record this season: 4-7      ERA: 4.00
• Road Record: 2-4
• Last 5 against Angels: 1-0

Why the Baltimore Orioles will win

• The Angels have lost each of their last eight games against the Orioles following a win.
• The Orioles have won each of their last 13 Monday games against AL West opponents that held a losing record.
• The Orioles have covered the run line each of their last 13 Monday games against AL West opponents that held a losing record.
• The Angels have failed to cover the run line in each of their last seven games against the Orioles following a road win.
• The Orioles have won the first inning in each of their last three night games against AL West opponents that held a losing record.
• The Orioles have led after 3 innings in each of their last nine Monday games against AL West opponents that held a losing record.
• The Orioles have led after 5 innings in each of their last 11 Monday night games against AL West opponents that held a losing record.

Total Runs Facts

• Seven of the Angels’ last eight night games against AL East opponents have gone UNDER the total runs line.
• Four of the Orioles’ last five games as favorites have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of Samuel Aldegheri’s last five appearances as a starter.
• There has been no run scored during the first inning in 13 of Kyle Bradish’s last 15 appearances as a starter.

Los Angeles Angels Player Prop Facts

• Mike Trout has hit a home run in each of his last two home appearances against the Orioles.
• Mike Trout has recorded at least one hit in each of his last 20 home appearances against AL East opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Gunnar Henderson has hit a home run in four of the Orioles’ last five road games against the Angels.
• Kyle Bradish has recorded seven or more strikeouts in seven of his last eight appearances against AL West opponents.
• Taylor Ward has recorded at least one hit in each of his last 12 appearances with his team as a road favorite against AL opponents.
• Taylor Ward ranks 10th amongst qualified players for On Base Percentage (.393) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (747).
• The Angels rank 30th in the league for walks allowed this season (367).
• The Orioles rank 28th in the league for strikeouts against this season (714).
• The Orioles rank 28th in the league for opponent batting average this season (.257).

Orioles vs Angels Prediction

The Orioles are 6-1 in their last 7 meetings against the Angels and are 3-1 in their last 4 visits in Los Angeles.

In this Orioles vs Angels Prediction, the Orioles are coming as -180 road favorites. I don’t get why the Orioles are being so big favorites on the road with Bradish on the mound and his 1.50+ WHIP. He has been weaker on the road with a 5+ ERA and the Orioles have been weaker against lefties, while facing Sam Aldegheri who sits on a 1.76 home ERA. Take the Angels to win at home for plus money.

Nikos Lagouretos's Pick: Los Angeles Angels ML