Southern Mississippi vs Iowa State Prediction 11/6/2026 Today’s College Basketball Picks

Southern Miss vs Iowa State Prediction

In this Southern Miss vs Iowa State Prediction, Iowa State is coming as -30.5 favorites. Both teams are coming off opposite outcomes in their opening games of the season, as Iowa State lost a close game against Memphis and Southern Miss had a much easier competition in Tougaloo, and won easily as expected. Southern Miss struggled on the road last season with a 4-11 record and will face an Iowa State team that will be playing its home opener of the season with frustration and in a bounce-back mode after losing their first game. Iowa State was almost perfect at home last season with just one loss in 17 home games and were elite against the spread, with a 23-14 ATS record. I expect a comfortable win for the home team, so take Iowa State and lay the points.

Iowa State Cyclones Preview

The Iowa State Cyclones have a 0-1 overall record and a 0-0 home record. They are coming off a 76-80 neutral loss against Memphis and will face Southern and Niagara next.

Offensively, they are averaging 76.0 points per game (ranking 201st in the nation), while allowing 80.0 points per game defensively (257th). They have a 107.1 offensive rating (ranking 200th) and a 112.8 defensive rating (256th). The Cyclones are shooting 43.1% from the field (ranking 226th in the nation) and 20.0% from beyond the arc (328th), while grabbing 36.0 rebounds per game (210th in the nation) and averaging 13.0 assists per game (211th). They have 4.0 blocks per game (130th in the nation) and 4.0 steals per game (319th).

Ryan Prather Jr. leads Iowa State in scoring, averaging 19 ppg on 54.5% shooting from the field. Dominykas Pleta follows with 15 ppg on 87.5% shooting from the field. Tamin Lipsey follows with 12 ppg on 30.8% shooting from the field. Tre Singleton leads the team in rebounds with 11 per game, and Jaquan Johnson leads the team in assists with 3 per game.

Southern Miss Golden Eagles Preview

The Southern Miss Golden Eagles have a 1-0 overall record and a 0-0 road record. They are coming off a 82-35 home win against Tougaloo and will face Jackson State and Texas State next.

Offensively, they are averaging 82.0 points per game (ranking 163rd in the nation), while allowing 35.0 points per game defensively (1st). They have a 106.4 offensive rating (ranking 209th) and a 45.4 defensive rating (1st). The Golden Eagles are shooting 42.4% from the field (ranking 235th in the nation) and 30.0% from beyond the arc (223rd), while grabbing 57.0 rebounds per game (15th in the nation) and averaging 11.0 assists per game (267th). They have 5.0 blocks per game (95th in the nation) and 15.0 steals per game (19th).

Isaac Taveras leads Southern Miss in scoring, averaging 12 ppg on 45.5% shooting from the field, also adding a team-high 9 rebounds per game. Cameron Wallace follows with 11 ppg on 55.6% shooting from the field. Brandon Weston follows with 9 ppg on 40% shooting from the field. Jalyke Gaines-Wyatt leads the team in assists with 5 per game.

Southern Miss Golden Eagles @ Iowa State Cyclones Betting Trends: November 6, 2026

Why the Iowa State Cyclones will win

• Iowa State has won each of its last 22 night games at James H. Hilton Coliseum against non-AP-ranked opponents.
• Southern Miss has lost each of its last three road games against non-Conference opponents.
• Southern Miss has lost the first half in three of its last four night games against AP-ranked opponents.

Why the Southern Miss Golden Eagles will win

• Iowa State has lost five of its last six night games.
• Southern Miss has won five of its last six night games against non-Conference opponents.
• Iowa State has lost the first half in three of its last four night games against non-Conference opponents.

Total Points Facts

• Twelve of Iowa State’s last 15 night games have produced a total of 150 or fewer points.

Matchup/League Facts

• Southern Miss ranks 1st among Division 1 teams for opponent field goal percentage this season (20.9%).
• Southern Miss ranks 1st among Division 1 teams for defensive rating this season (45.2).

Nikos Lagouretos's Pick: Iowa State -30.5