Oregon vs Penn State Prediction 9/27/2025 Today’s College Football Picks

In this article we will formulate an Oregon vs Penn State prediction for this College Football game on Saturday, September 27th at Beaver Stadium in University Park, Pennsylvania. Let’s take a look at the prediction for this week 5 matchup. 

Oregon Ducks Betting Preview

The Oregon Ducks are 4-0 (1-0) this year after they defeated Oregon State by a score of 41-7 in their last game. Oregon was tied at seven after the first quarter and they led 21-7 at halftime, before cruising to the victory in the second half. The Ducks out gained Oregon State by a total of 585-147, went 4-10 on third downs, and won the turnover battle by a total of 1-0 in the game. Dante Moore went 21-31 for 305 yards and four touchdowns, while Jayden Limar rushed 12 times for 70 yards. Gary Bryant Jr led the Oregon receivers with three catches for 65 yards and one touchdown in the win. The Oregon defense recorded zero sacks and just two tackles for loss in the game. 

Oregon has also picked up wins against Montana State, Oklahoma State, and Northwestern so far this year. The Ducks are averaging 51.3 points per game with 268.5 passing yards and 255.3 rushing yards per game, while they are allowing 9.3 points against per game this season. Dante Moore has completed 74.7% of his passes for 962 yards, 11 touchdowns, and one interception, while Dakorien Moore has caught 12 passes for 207 yards and two scores. Jayden Limar is the leading rusher for Oregon with 32 carries for 215 yards and three touchdowns this year. 

Penn State Nittany Lions Betting Preview

The Penn State Nittany Lions are 3-0 (0-0) this season after they defeated Villanova by a score of 52-6 in their last game. Penn State led 7-0 after the first quarter and 21-0 at halftime, before scoring 31 points in the second half for the blowout win. The Nittany Lions out gained Villanova by a total of 465-179, went 5-11 on third downs, and won the turnover battle by a total of 2-1 in the game. Drew Allar went 16-29 for 209 yards, one touchdown, and one interception, while Kaytron Allen rushed for 86 yards and one score. Luke Reynolds led the way with four catches for 73 yards in the win. The PSU defense recorded three sacks and 11 tackles for loss in the victory. 

Penn State also has wins over Nevada and FIU by a combined score of 80-11 this year. The Nittany Lions are averaging 44.0 points per game with 243.7 passing yards and 193.7 rushing yards per game, while they are allowing 5.7 points against per game this season. Drew Allar has completed 64.8% of his passes for 626 yards, four touchdowns, and one interception, while Trebor Pena has caught 13 passes for 166 yards and one score. Kaytron Allen has led the PSU rushing attack with 34 carries for 273 yards and three touchdowns this season. 

Why Penn State will beat Oregon 

Penn State has won each of its last 15 home games in September.
Oregon has lost seven of its last eight games as an underdog against AP-ranked teams.
The favorite has covered the spread in six of Oregon’s last seven games.
Oregon has failed to cover the spread in six of its last eight games as an underdog against AP-ranked teams.

Total Points Facts

Each of Penn State’s last five games against AP-ranked teams at West Shore Home Field at Beaver Stadium have gone UNDER the total points line.
Each of Oregon’s last four games as an underdog against AP-ranked teams have gone OVER the total points line.

Matchup/League Facts

Penn State has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (3).
Penn State has recorded the equal-most home wins by a margin of 30+ points of any FBS team this season (3).
Oregon has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (3).
Oregon has recorded the equal-most home wins by a margin of 30+ points of any FBS team this season (3).

Oregon vs Penn State Prediction 

Penn State has played three very bad opponents to start this season, so this will be a huge upgrade in competition, but they will be at home. The Nittany Lions have a ton of talent on paper and a lot of experience, but we will see how quickly they can adjust to playing another top ranked team. On the other side, Oregon has also played an easy schedule, but did go on the road against Northwestern and played a pair of OSU’s. This should be a fantastic game and I think either side could win, but I think the moment might be too big for Dante Moore against this experienced PSU squad. Take Penn State at home. 

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