St. Louis City SC vs Philadelphia Union 3/22/25 Prediction MLS Picks

St. Louis City SC will visit Philadelphia Union on Saturday, March 22, 2025, at Subaru Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis City SC vs Philadelphia Union Prediction. We will examine:

Philadelphia Union recent form and player performance

St. Louis City SC recent form and player performance

Recent betting trends and streaks involving Philadelphia Union

Recent betting trends and streaks involving St. Louis City SC

Recent betting trends in games played between the St. Louis City SC and Philadelphia Union

A summary that ties it all together and produces a favorable betting outcome for St. Louis City SC vs Philadelphia Union game

Philadelphia Union Preview

Philadelphia has 9 points this season and are sitting on the second place of the Eastern Conference. Philadelphia has a 3-1 record this season, while having a 1-1 home record. Philadelphia is coming off a 1-3 home defeat by Nashville, ending their three-game winning streak that they were running to start the season. Over is 3-1 in their 4 games this season, and Both teams to score – Yes is also 3-1 in their 4 games.    

Philadelphia is averaging 2.75 goals per game, which is the best in the whole MLS this season, while allowing 1.50 goals per game, which is tied for 9th in the Eastern conference. Thai Baribo is the top scorer for Philadelphia this season with 5 total goals, which is also the best in the league.

St. Louis City SC Preview

St. Louis City has 8 points this season and are tied with two more teams in the second place of the Western Conference. St. Louis City has been undefeated this season with a 2-0-2 record this season and are 1-0-1 on the road. St. Louis City is coming off a 1-0 home victory over the Seattle Sounders, marking their second straight victory this season after starting with two consecutive draws. Under is 3-1 in their 4 games this season, and Both teams to score – No has hit in all of their four games. 

St. Louis City is averaging 1.00 goals per game, which is tied for 10th in the Western Conference, while having conceded zero goals this season, which is the best in the league. Four players with one goal apiece lead St. Louis City’s offense this season.

Why Philadelphia Union will win

• St. Louis CITY SC has lost three of its last four MLS away games following a win.
• St. Louis CITY SC has lost three of its last four MLS games as an underdog following a win.

Why St. Louis City SC will win

• The underdog has won each of Philadelphia Union’s last five MLS games.
• The underdog has won each of Philadelphia Union’s last three MLS games at Subaru Park.
• Philadelphia Union has lost four of its last five MLS games as a home favorite following a loss.
• The underdog has won four of Philadelphia Union’s last six MLS games at Subaru Park.
• Philadelphia Union is winless in its last three MLS games as a favorite.
• Philadelphia Union has lost four of its last six MLS games as a favorite following a loss.
• Philadelphia Union has won three of its last four MLS games.

Total Points Facts

• The ‘Both Teams to Score’ market has hit in seven of Philadelphia Union’s last eight MLS games.
• The ‘Both Teams to Score’ market has failed to hit in six of St. Louis CITY SC’s last seven MLS games.
• The ‘Over 2.5 Goals’ market has hit in six of Philadelphia Union’s last seven MLS games.

St. Louis City SC vs Philadelphia Union Prediction

Their only previous meeting was back in 2023 in a friendly game, where both teams had a 2-2 draw. In this St. Louis City SC vs Philadelphia Union Prediction, Philadelphia is coming as +125 home favorites. This is a tricky one, as Philadelphia is coming off their first loss of the season, while Saint Louis has been undefeated. This is a clash of completely opposite styles, as Philadelphia have the best offense in the MLS, and are going up against the best defense in Saint Louis. I really like Saint Louis draw no bet in this spot, meaning that with a draw or Saint Louis win, we cash. Take St. Louis City SC at an Asian Handicap of +0.5 at -155 odds.