Red Wings vs Sabres Prediction 10/22/2025 Today’s NHL Picks

In this article we will formulate a Red Wings vs Sabres prediction for this NHL game on Wednesday, October 22nd at the KeyBank Center in Buffalo, New York. Let’s take a look at the prediction for this NHL matchup.

Detroit Red Wings Betting Preview

The Detroit Red Wings are 5-1-0 this year after they defeated Edmonton by a score of 4-2 in their last game. Detroit had their lead cut to 3-2 in the third period, but they added an empty net goal to put the game out of reach. The Red Wings out shot Edmonton by a total of 25-18, won 56.5% of the face-offs, and went 0-0 on the power play in the game. Detroit got goals from Finnie (2) and Larkin (2), while Seider led the team with five hits. The Red Wings started John Gibson in net, who stopped 16 out of 18 shots in the game, which was an .889 save percentage. 

Prior to that game, Detroit defeated Tampa Bay by a score of 2-1 and Florida by a score of 4-1. The Red Wings have won five games in a row and they are currently first in the Atlantic standings with 10 points. Detroit has scored 3.33 goals per game and they have allowed 2.33 goals against per game, while also going 22.2% on the power play and 92.3% on the penalty kill this season. Dylan Larkin has led Detroit with five goals and six assists, while Alex DeBrincat has added six assists. The projected starting goalie for the Red Wings is John Gibson, who is 2-1-0 with a 2.99 goals against average and an .873 save percentage this year. 

Buffalo Sabres Betting Preview

The Buffalo Sabres are 2-4-0 this season after they lost to Montreal by a score of 4-2 in their last game. Buffalo cut the deficit to 3-2 in the third period, but couldn’t find the tying goal in the loss. The Sabres out shot Montreal by a total of 32-31, won 43.6% of the face-offs, and went 0-1 on the power play in the game. Buffalo got goals from Kozak and Kulich, while Krebs led the way with four hits. The Sabres started Alex Lyon in goal, who stopped 27 out of 30 shots, which was a .900 save percentage. 

Prior to that loss, Buffalo defeated Florida by a score of 3-0 and Ottawa by a score of 8-4. The Sabres have won two of their last three games and they are currently at the bottom of the Atlantic standings with four points. Buffalo has scored 2.50 goals per game and they have allowed 3.00 goals against per game, while also going 26.3% on the power play and 95.8% on the penalty kill this season. Zach Benson has led Buffalo with six assists, while Josh Doan and Rasmus Dahlin have each added five points. The projected starting goalie for Buffalo is Alex Lyon, who is 2-4-0 with a 2.55 goals against average and a .924 save percentage this season. 

Why the Detroit Red Wings will win

The Red Wings have won seven of their last eight games as underdogs.
The Sabres have lost three of their last four games as favorites following a road loss.
The underdogs have covered the puck line in each of the Red Wings’ last seven games.
The Sabres have failed to cover the puck line in 12 of their last 13 Wednesday games as home favorites.
The Red Wings have won the third period in each of their last four night games against the Sabres when trailing after the second period.

Total Goals Facts

Each of the Sabres’ last six games against opponents on a winning streak have gone UNDER the total goals line.
Nine of the Red Wings’ last 10 night games at KeyBank Center have gone OVER the total goals line.
The ‘Over 1.5 Goals Period 2′ market has hit in each of the Sabres’ last eight games as favorites against the Red Wings.
The ‘Over 1.5 Goals Period 2′ market has hit in each of the Red Wings’ last seven night games at KeyBank Center.

Buffalo Sabres Player Prop Facts

Alex Tuch has scored at least one goal in seven of the Sabres’ last eight games as favorites.
Jason Zucker has recorded at least one point in 11 of his last 12 appearances with his team as a favorite against the Red Wings.
Rasmus Dahlin has recorded at least one assist in seven of the Sabres’ last eight home games against Atlantic Division opponents.

Detroit Red Wings Player Prop Facts

Lucas Raymond has scored a goal in each of the Red Wings’ last three road games against the Sabres.
Dylan Larkin has recorded at least one point in each of his last 13 Wednesday appearances against Eastern Conference opponents.
Lucas Raymond has recorded at least one assist in each of the Red Wings’ last five games against the Sabres.

Red Wings vs Sabres Prediction 

Detroit comes into this matchup looking for their sixth straight win and they have played great defense, as they have allowed two goals or fewer in four straight games. The Red Wings are 1-0-0 on the road this year, while the Sabres are 2-2-0 at home. Buffalo has played better in their last three games, but I still don’t love their offense. The Sabres have also been playing Alex Lyon in net, who we know is very inconsistent. Take the Red Wings to win again here.