Bruins vs Sabres Prediction 4/21/2026 Today’s NHL Picks

In this article we will formulate a Bruins vs Sabres prediction for this NHL game on Tuesday, April 21st at the KeyBank Center in Buffalo, New York. Let’s take a look at the prediction for this NHL playoff matchup.

Boston Bruins Betting Preview

The Boston Bruins are down 0-1 in this series after they lost game one by a score of 4-3 on Sunday. Boston led 1-0 after two periods and 2-0 late in the game, but they allowed four goals in the last eight minutes for the heartbreaking loss. The Bruins were out shot by a total of 38-20, won 50.8% of the face-offs, and went 1-3 on the power play in the game. Boston got goals from Geekie, Lindholm, and Pastrnak, while Swayman stopped 34 out of 37 shots, which was a .919 save percentage. 

Prior to that game, Boston defeated the Devils by a score of 4-0 and the Blue Jackets by a score of 3-2. The Bruins have lost six of their last seven games and they finished fourth in the Atlantic standings with 100 points. Boston scored 3.27 goals per game and they allowed 3.01 goals against per game, while also going 23.4% on the power play and 76.9% on the penalty kill this season. David Pastrnak led Boston with 29 goals and 71 assists, while Morgan Geekie added 39 goals and 29 assists. The projected starting goalie for Boston is Jeremy Swayman, who was 31-18-4 with a 2.71 goals against average and a .908 save percentage this season. 

Buffalo Sabres Betting Preview

The Buffalo Sabres are up 1-0 in this series after a dramatic win in game one by a score of 4-3. Buffalo trailed 2-0 in the third period, but they scored four goals in the span of about seven minutes to get the comeback victory. The Sabres recorded 38 shots on goal, won 49.2% of the face-offs, and went 0-4 on the power play in the game. Buffalo got goals from Thompson (2), Tuch, and Samuelsson, while UPL stopped 17 out of 20 shots, which was an .850 save percentage.

Prior to that game, Buffalo lost to the Stars by a score of 4-3, but did beat the Blackhawks by a score of 5-1 before that. The Sabres have won five of their last six games and they finished first in the Atlantic standings with 109 points. Buffalo scored 3.45 goals per game and they allowed 2.93 goals against per game, while also going 19.5% on the power play and 81.9% on the penalty kill this season. Tage Thompson led Buffalo with 40 goals and 41 assists, while Alex Tuch added 33 goals and 33 assists. The projected starting goalie for Buffalo is Ukko-Pekka Luukkonen, who was 22-9-3 with a 2.52 goals against average and a .910 save percentage this season. 

Why the Buffalo Sabres will win

• The Bruins have lost each of their last five Game 2s of a playoff series.
• The Sabres have won each of their last four home games against Eastern Conference opponents.
• The favorites have covered the puck line in nine of the Bruins’ last 11 games at KeyBank Center.
• The Bruins have lost the third period in each of their last five games against Atlantic Division opponents when leading after the second period.

Why the Boston Bruins will win

• The Bruins have won eight of their last nine games at KeyBank Center following a road loss.
• The Sabres have lost four of their last six games as home favorites against Atlantic Division opponents.
• The underdogs have covered the puck line in 15 of the Sabres’ last 16 games at KeyBank Center.
• The Sabres have failed to cover the puck line in each of their last seven games as home favorites.
• The Sabres have lost the second period in each of their last three games as favorites against Eastern Conference opponents when leading after the first period.

Total Goals Facts

• Five of the last six night games between two teams from the Atlantic Division have gone OVER the total goals line.
• Five of the Sabres’ last six night games against the Bruins following a home win have gone UNDER the total goals line.
• Four of the Bruins’ last five night games at KeyBank Center have gone OVER the total goals line.
• The ‘Over 1.5 Goals Period 1′ market has hit in four of the Sabres’ last five home games against Atlantic Division opponents.
• The ‘Over 1.5 Goals Period 3′ market has hit in each of the Bruins’ last five games as underdogs against Atlantic Division opponents.

Buffalo Sabres Player Prop Facts

• Alex Tuch has scored a goal in each of the Sabres’ last three games.
• Tage Thompson has recorded at least one assist in each of the Sabres’ last four games as favorites against the Bruins.
• Mattias Samuelsson has scored two goals against the Bruins this season – equal-most against any opponent.

Boston Bruins Player Prop Facts

• Morgan Geekie has scored the first goal in three of the Bruins’ last four games against Eastern Conference opponents.
• David Pastrnak has scored a goal in each of the Bruins’ last four games as underdogs against the Sabres.
• David Pastrnak has recorded at least one assist in each of his last 11 Tuesday night appearances against Atlantic Division opponents.
• David Pastrnak has scored four goals against the Sabres this season – most against any opponent.

Matchup/League Facts

• The Buffalo Sabres are one of seven teams to rank in the top 10 for both goals scored and goals conceded per game this season.
• The Buffalo Sabres rank T2nd in the league in short handed goals this season (11).
• The Boston Bruins rank T30th in the league in short handed goals this season (2).
• The Boston Bruins are one of only four teams to win a game when trailing by 3 or more goals after Period 1 this season.

Bruins vs Sabres Prediction 

Buffalo was very fortunate to escape game one with a win, but they have all of the momentum coming into this matchup. The Sabres were 26-10-5 at home this year, while the Bruins were 16-16-9 on the road. Boston played very well in the first 50 minutes of game one, but they have nothing to show for it. I think Boston could start this game slow, as they try to bounce back from game one, but I expect a defensive battle and doubt we see the late scoring we saw in game one. Take the under here.

David Racey's Pick: Under 6.5