Titans vs 49ers Prediction 12/14/2025 Today’s NFL Picks

In this article we will formulate a Titans vs 49ers prediction for this NFL game on Sunday, December 14th at Levi’s Stadium in Santa Clara, California. Let’s take a look at the prediction for this week 15 matchup.

Tennessee Titans Betting Preview

The Tennessee Titans are 2-11 this season after they defeated Cleveland by a score of 31-29 in their last game. Tennessee trailed 17-14 at halftime, but they led 31-17 in the fourth, before needing a late stop on a two point conversion to get the win. The Titans were out gained by a total of 412-292, went 6-17 on third downs, and won the turnover battle by a total of 2-1 in the game. Cam Ward went 14-28 for 117 yards, two touchdowns, and one interception, while Tony Pollard rushed 25 times for 161 yards and two scores. Tyjae Spears led the receivers with two catches for 28 yards in the win. 

Prior to that game, Tennessee lost to the Jaguars by a score of 25-3 and the Seahawks by a score of 30-24. The Titans have lost seven of their last eight games and they are currently last in the AFC South standings. Tennessee has scored 15.5 points per game with 161.3 passing yards and 84.9 rushing yards per game, while they have allowed 27.5 points against per game this season. Cam Ward has thrown for 2,468 yards, nine touchdowns, and seven interceptions, while Tony Pollard has rushed for 743 yards and four scores this season. 

San Francisco 49ers Betting Preview

The San Francisco 49ers are 9-4 this year after they defeated Cleveland by a score of 26-8 in their last game. San Francisco led 10-8 at halftime and outscored Cleveland 16-0 in the second half for the lopsided win. The 49ers were out gained by a total of 253-252, went 11-17 on third downs, and won the turnover battle by a total of 2-0 in the game. Brock Purdy went 16-29 for 168 yards and one touchdown, while Christian McCaffrey rushed 20 times for 53 yards and one score. George Kittle led the receivers with four receptions for 67 yards in the win. 

Prior to that game, San Francisco defeated the Panthers by a score of 20-9 and the Cardinals by a score of 41-22. The 49ers have won three games in a row and they are currently third in the NFC West standings. San Francisco has scored 23.6 points per game with 242.6 passing yards and 98.5 rushing yards per game, while they have allowed 20.7 points against per game this season. Brock Purdy has thrown for 1,147 yards, nine touchdowns, and seven interceptions, while Christian McCaffrey has rushed for 849 yards and eight scores on 237 carries this year. McCaffrey has also led the receivers with 85 receptions for 806 yards and five touchdowns. 

Why the San Francisco 49ers will win

• The 49ers have won each of their last 10 games at Levi’s Stadium when playing with a rest advantage.
• The Titans have lost each of their last 10 Sunday games against opponents on a winning streak.
• The Titans have failed to cover the spread in each of their last eight games as underdogs following a win.
• The 49ers have covered the spread in each of their last seven games as favorites against starting rookie QBs.
• The 49ers have won the first half in each of their last eight games at Levi’s Stadium against teams that held a losing record.
• The Titans have lost the first quarter in four of their last five road games.

Total Points Facts

• Each of the Titans’ last four December games as underdogs have gone OVER the total points line.
• Six of the 49ers’ last seven home games against AFC opponents have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Brock Purdy has recorded 22+ completions in each of his last three home appearances.
• Brock Purdy has recorded 244+ passing yards in nine of the 49ers’ last 10 games at Levi’s Stadium as heavy favorites (>-7.0 points).
• Christian McCaffrey has scored at least one touchdown in nine of his last 10 regular season appearances with the 49ers as favorites against AFC opponents.
• Brock Purdy has recorded 13+ rushing yards in five of his last six Sunday home appearances.
• Christian McCaffrey has recorded 128+ rushing and receiving yards in seven of his last eight appearances with the 49ers as favorites in California.
• Christian McCaffrey has recorded 40+ receiving yards in each of the 49ers’ last eight games played on the West Coast.
• Heading into Week 15, Christian McCaffrey is the only players averaging over 20.0 rushing yards and 60.0 receiving yards per game this season.

Tennessee Titans Player Prop Facts

• Cam Ward has recorded 21+ completions in seven of the Titans’ last nine games as underdogs.
• Cam Ward has recorded 222+ passing yards in three of the Titans’ last four games as road underdogs.
• Tyjae Spears has recorded 19+ rushing yards in five of his last six road appearances.
• Tyjae Spears has recorded 47+ rushing and receiving yards in five of his last six road appearances.
• Tyjae Spears has recorded 18+ receiving yards in each of the Titans’ last eight games as underdogs.
• Cam Ward has 879 passing yards through his first five career games – most by any player since Jayden Daniels, (2024).

Matchup/League Facts

• Heading into Week 15, the 49ers have won the first quarter in each of their last three games – longest active streak in the league.
• Heading into Week 15, the 49ers have recorded the lowest single-game yard differential in a win this season (-207 vs Arizona Cardinals in Week 11).
• Heading into Week 15, the Titans rank 1st in the NFL in average punt return (18.9 yards) this season.
• Heading into Week 15, the Titans rank 32nd in the NFL in 3rd down percentage (29.9%) this season.

Titans vs 49ers Prediction 

San Francisco comes into this matchup right in the middle of the NFC West race and they can’t afford to drop this game. The 49ers are 3-2 at home this year and they have allowed a total of 17 points in their last two games. Tennessee is 2-4 on the road and they have allowed at least 25 points in four of their last five overall. San Francisco is the much better team in this matchup and they should be relatively healthy coming off of the bye week. Take the 49ers to run away with this game in the second half.

David Racey is 82-68 (55%) in the NFL this season and is one of the top NFL cappers on the NFL Leaderboard. Click here for his premium plays for this week!

David Racey's Pick: 49ers -12.5