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Tennessee Titans vs Houston Texans Prediction 9/28/2025 Today’s NFL Picks
Pick details
Tennessee (0-3) vs Houston (0-3)
September 28, 2025 at 01:00 PM EDT
The Line: Betting Odds: Houston -6.5 — Over/Under: +39.5
Tennessee Titans Betting Preview
The Tennessee Titans lost to the Colts and Rams, and they play the Cardinals next. The Tennessee Titans have lost 9 straight games. Cam Ward is completing 54.5 percent of his passes for 506 yards, 2 touchdowns, and 1 interception. Chig Okonkwo and Calvin Ridley have combined for 231 receiving yards on 20 catches, while Elic Ayomanor has 10 receptions.
The Tennessee Titans ground game is averaging 88.7 yards per contest, and Tony Pollard leads the way with 197 yards and 1 touchdown. Defensively, Tennessee is allowing 31.3 points and 373.7 yards per game. Cody Barton leads the Tennessee Titans with 20 tackles, Jeffery Simmons has 1 sack and Xavier Woods has 1 interception.
Houston Texans Betting Preview
The Houston Texans lost to the Buccaneers and Jaguars, and they play the Ravens next. The Houston Texans have lost 5 of their last 6 regular season games. C.J. Stroud is completing 64 percent of his passes for 599 yards, 2 touchdowns, and 3 interceptions. Nico Collins and Dalton Schultz have combined for 277 receiving yards and 2 touchdowns, while Xavier Hutchinson has 7 receptions.
The Houston Texans ground game is averaging 95 yards per contest, and Nick Chubb leads the way with 141 yards and 1 touchdown. Defensively, Houston is allowing 17 points and 315.7 yards per game. Azeez Al-Shaair leads the Houston Texans with 25 tackles, Will Anderson Jr. has 3 sacks and Jalen Pitre has 1 interception.
Tennessee Titans @ Houston Texans Betting Trends: Week 4
Why the Houston Texans will win
- The Titans have lost each of their last nine Sunday games.
- The Texans have won 11 of their 12 previous Week 4 home games against AFC opponents.
- The Titans have failed to cover the spread in each of their last six games against teams that held a losing record.
- The Texans have covered the spread in each of their last four games against the Titans following a loss.
- The Texans have won the first quarter in four of their five previous Week 4 home games against AFC South opponents.
- The Titans have lost the first half in each of their last four road games.
Why the Tennessee Titans will win
- The Titans have won each of their last five Week 4 games as underdogs.
- The Texans have lost four of their last five games in September.
- The Texans have failed to cover the spread in each of their last 10 games as home favorites following a road loss.
- The Titans have covered the spread in each of their last five Week 4 games as underdogs.
- The Texans have lost the first half in three of their last four games.
- The Titans have won the first quarter in three of their last four games as underdogs against AFC South opponents.
Total Points Facts
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- Nine of the Texans’ last 10 games as home favorites have gone UNDER the total points line.
- Six of the Titans’ last seven games as underdogs have gone OVER the total points line.
- Nine of the last 12 Sunday games at NRG Stadium have gone UNDER the total points line.
Houston Texans Player Prop Facts
- Nico Collins has scored the first touchdown in three of the Texans’ last four games at NRG Stadium.
- Nico Collins has scored at least one touchdown in eight of his last nine home appearances.
- Christian Kirk has recorded 39+ receiving yards in 10 of his last 11 home appearances against division opponents.
- Nick Chubb has recorded 60+ rushing and receiving yards in each of his last 19 Sunday appearances with his team as a home favorite.
- C.J. Stroud has recorded 234+ passing yards in seven of the Texans’ last eight games as favorites against AFC South opponents.
- Nick Chubb has recorded 56+ rushing yards in each of his last 18 appearances with his team as a home favorite against AFC opponents.
- C.J. Stroud has recorded 23+ completions in each of the Texans’ last four games at NRG Stadium as moderate favorites (-3.5 to -7.0 points).
- Heading into Week 4, Nico Collins ranks T1st in the AFC for 20+ yard receiving touchdowns (2) this season.
Tennessee Titans Player Prop Facts
- Tony Pollard has recorded 82+ rushing yards in four of his last five September appearances with his team as a road underdog.
- Tyler Lockett has recorded 13+ receiving yards in each of his 10 previous Week 4 appearances.
- Tyjae Spears has scored at least one touchdown in each of the Titans’ last three games as underdogs against teams with a losing record.
- Calvin Ridley has recorded 78+ rushing and receiving yards in each of his last seven road appearances against AFC South opponents.
- Heading into Week 4, Joey Slye ranks T1st in the NFL in 50+ yard field goals made (4) this season.
Matchup/League Facts
- Heading into Week 4, the Texans rank 32nd in the NFL in 1st downs (43) this season.
- Heading into Week 4, the Texans rank 32nd in the NFL in red zone percentage (0.0%) this season.
- Heading into Week 4, the Titans have recorded fewer total yards than their opponents in each of their last three games – equal-longest active streak in the league.
- Heading into Week 4, the Titans have allowed an average of 30.3 points over their last seven games – most in the league over that span.
Tennessee Titans vs Houston Texans Prediction
The Texans are going to get the benefit of the doubt because they’re supposed to be better than their record, and they’re led by a quarterback who has shown things. The Titans are a mess across the board, and Ward is taking his licks as a rookie quarterback. With that said, the Texans are what they are until proven otherwise, and I’m not backing them in the big favorite role regardless of opponent. The Texans are awful offensively and actually dead last in scoring. The Texans are 4-10-1 ATS in their last 15 games when favorites of 5 or more points. This is a fade of the Texans more than anything. Give me the Titans and the points.
Randy Chambers's Pick: Tennessee Titans +6.5
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