Tennessee Titans vs Arizona Cardinals Prediction 10/5/2025 Today’s NFL Picks

The Tennessee Titans and the Arizona Cardinals meet Sunday in NFL action from State Farm Stadium. Here’s a Titans vs Cardinals prediction. We will look at this from a betting perspective and determine the best Titans vs Cardinals pick. We will examine:

The Tennessee Titans recent form and player performance

The Arizona Cardinals recent form and player performance

Recent betting trends and streaks involving the Tennessee Titans

Recent betting trends and streaks involving the Arizona Cardinals

Recent betting trends in games played between the Titans and Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Titans vs Cardinals game

Tennessee Titans Betting Preview

To put it mildly, the Titans have been struggling this year. Tennessee opened up the season with a 20-12 loss versus the Denver Broncos, then lost 33-19 versus the Los Angeles Rams. The Titans kept the losing streak going in Week 3 versus the Indianapolis Colts, logging a 41-20 defeat. In that one Tennessee gained just 282 yards on offense (196 rushing) with 4.3 yards per play, 21 first downs and a 5-of-14 success rate on third-down conversions. On defense the Titans surrendered 365 yards (228 passing), 6.9 yards per play and 22 first downs.

In Week 4 versus the winless Houston Texans, Tennessee’s woes continued. The Titans managed to hang around most of the game, entering the fourth quarter with a 6-0 deficit. After 20 unanswered points however, Tennessee had a 26-0 shutout loss. QB CJ Stroud had a couple of TDs and 233 yards on 22-of-28 passing, while leading rusher Jo’quavious Marks carried 17 times for 69 yards and a touchdown. Nico Collins was the leading receiver in the losing effort, logging four grabs for 79 yards in total.

Arizona Cardinals Betting Preview

Over on the Cardinals’ side, they got off to a good start this year, bagging wins in their first two games—each by one score. Arizona took out the New Orleans Saints in a road matchup during the opener on September 7, then powered out a 27-22 win over the Carolina Panthers the next weekend. Game three was the Cardinals’ first loss however, as they’d fall 16-15 versus the San Francisco 49ers in a rough outcome. In that defeat Arizona managed a tepid 260 yards of offense (154 passing) with 16 first downs and 5-of-15 on third downs. The defense gave up 355 yards (282 passing) on the other side but held the Niners to just 2-of-10 on third downs.

Last weekend in their most recent outing versus the Seattle Seahawks, the Cardinals were in trouble with a 17-6 deficit heading into the fourth quarter. Arizona managed to make a game of it with two more scores but still lost 23-20 in the end. QB Kyler Murray was 27-of-41 for 200 yards, two scores and two picks while also leading the rush on five carries for 41 yards. Tops in receiving was Marvin Harrison Jr. with six catches for 66 yards and a touchdown of his own.

Tennessee Titans @ Arizona Cardinals Betting Trends: Week 5

Why the Arizona Cardinals will win

The Titans have lost each of their last 10 Sunday games.
The Cardinals have won each of their last four games against AFC opponents.
The Titans have failed to cover the spread in each of their last seven games against NFC opponents.
The Cardinals have covered the spread in eight of their last nine games against AFC opponents.
The favorites have won the first quarter in each of the Cardinals’ last five Week 5 games.
The favorites have won the first half in seven of the Cardinals’ last eight games.

Why the Tennessee Titans will win

The Titans have won eight of their last nine games against NFC West opponents on a losing streak.
The Cardinals have lost three of their last four games as favorites following a home loss.
The Cardinals have failed to cover the spread in six of their last seven games at State Farm Stadium when playing with a rest advantage.
The road team has covered the spread in five of the Cardinals’ last six games.
The Titans have won the first quarter in six of their last eight games against the Cardinals.
The Titans have won the first half in seven of their last nine Week 5 games against NFC opponents.

Total Points Facts

Each of the Cardinals’ last seven games as home favorites following a loss have gone OVER the total points line.
Four of the Titans’ last five Week 5 road games have gone UNDER the total points line.
Fourteen of the last 18 Sunday games at State Farm Stadium have gone OVER the total points line.

Titans vs Cardinals Prediction

I’m staying with Arizona, but you could probably argue this one either way. The Cardinals have a couple of close losses in their last two games, including a three-point margin versus Seattle last weekend. In that one Arizona gained 253 yards (164 passing) with 4.0 yards per play, 18 first downs, 6-of-15 on third-down tries and a couple of interceptions. The Cardinals gave up 384 yards (229 passing) on the other side with 6.0 yards per play and 20 first downs. All things considered the defense didn’t do a terrible job of keeping the team in the game, as they have all season so far. Arizona has given up no more than 23 points in any outing but they’ve scored fewer than 21 points in three of four. It shouldn’t be too hard to keep Tennessee’s offense in check, but this is looking like a low-scoring game overall.