Tampa Bay Buccaneers vs Carolina Panthers Prediction 12/21/2025 Today’s NFL Picks

In this article, we will formulate a Buccaneers vs Panthers Prediction for this NFL Week 13 game on Sunday, December 21st. Let’s take a look at the prediction for this NFL matchup.

Carolina Panthers Preview

The Carolina Panthers have a 7-7 record this season and are sitting first in the NFC South. They are 8-6 ATS, 7-7 in Over/Under and have a 4-2 home record and a 3-5 away record. The Panthers are coming off a 17-20 away loss against the New Orleans Saints and will face the Seahawks and Buccaneers next.

Offensively, the Panthers average 18.9 points per game, ranking 28th in the NFL, while defensively, they allow 22.6 points per game, which is 14th. Carolina averages 309 total yards per game (183.4 passing and 125.6 rushing), while allowing 331.5 total yards per game (116 rushing and 215.5 passing).

Bryce Young leads the Panthers with 2500 passing yards with 63.3% completed passes and 19 touchdowns. Rico Dowdle leads the team in rushing yards with 978, while Tetairoa McMillan has a team-high 59 receptions for 851 receiving yards, and 6 touchdowns. Defensively, Christian Rozeboom has a team-high 97 total tackles (46 of them solo), while Derrick Brown leads the team in sacks, with 4.0, while Jaycee Horn leads the team with 5 interceptions.

Tampa Bay Buccaneers Preview

The Tampa Bay Buccaneers have a 7-7 record this season and are sitting first in the NFC South. They are 5-9 ATS, 8-6 in Over/Under and have a 3-4 home record and a 4-3 away record. The Buccaneers are coming off a 28-29 home loss against the Atlanta Falcons and will face the Dolphins and Panthers next.

Offensively, the Buccaneers average 23.4 points per game, ranking 16th in the NFL, while defensively, they allow 25.3 points per game, which is 24th. Tampa Bay averages 316.6 total yards per game (203.4 passing and 113.2 rushing), while allowing 348.2 total yards per game (101.4 rushing and 246.9 passing).

Baker Mayfield leads the Buccaneers with 2999 passing yards with 61.2% completed passes and 22 touchdowns. Rachaad White leads the team in rushing yards with 494, while Emeka Egbuka has a team-high 58 receptions for 870 receiving yards, and 6 touchdowns. Defensively, Tykee Smith has a team-high 90 total tackles (54 of them solo), while YaYa Diaby leads the team in sacks, with 6.0, while Jamel Dean leads the team with 3 interceptions.

Tampa Bay Buccaneers @ Carolina Panthers Betting Trends: Week 16

Why the Carolina Panthers will win

• The underdogs have won seven of the Panthers’ last eight games at Bank of America Stadium.
• The Buccaneers have lost three of their last four games as favorites.
• The Panthers have covered the spread in each of their last 11 games as underdogs following a loss.
• The Buccaneers have failed to cover the spread in each of their last six games.
• The Buccaneers have lost the first half in seven of their eight previous Week 16 games against NFC South opponents.
• The Panthers have won the first quarter in three of their last four games as home underdogs against NFC opponents.
• The Panthers have scored the first touchdown in each of their last five games against NFC South opponents.

Why the Tampa Bay Buccaneers will win

• The Panthers have lost 12 of their last 13 games when playing with a rest disadvantage.
• The Buccaneers have won nine of their last 10 games against the Panthers.
• The Buccaneers have covered the spread in each of their last seven road games following a Division game.
• The Panthers have failed to cover the spread in each of their last five Week 16 games against NFC South opponents.
• The Buccaneers have won the first quarter in each of their last five December games against the Panthers.
• The Buccaneers have scored the first touchdown in seven of their last eight games as favorites following a loss.
• The Panthers have lost the first half in 16 of their last 17 games following a road loss.

Total Points Facts

• Each of the Buccaneers’ last six games without Antoine Winfield Jr. have gone OVER the total points line.
• Each of the Panthers’ last six games without Chuba Hubbard have gone OVER the total points line.
• Eleven of the last 13 Sunday games at Bank of America Stadium have gone OVER the total points line.

Carolina Panthers Player Prop Facts

• Rico Dowdle has scored a touchdown in seven of his last eight home appearances against division opponents.
• Xavier Legette has recorded 23+ receiving yards in each of his seven previous appearances with the Panthers as underdogs against NFC South opponents.
• Chuba Hubbard has recorded 65+ rushing and receiving yards in each of his last 12 appearances with the Panthers as underdogs following a road loss.
• Tetairoa McMillan has scored the last touchdown in four of the Panthers’ last five games as underdogs against NFC opponents.
• Chuba Hubbard has recorded 56+ rushing yards in 11 of his last 12 appearances with the Panthers as underdogs following a road loss.
• Heading into Week 16, Jaycee Horn has recorded the equal-most interceptions in a single game this season (2 vs Jets, Week 7).

Tampa Bay Buccaneers Player Prop Facts

• Bucky Irving has scored a touchdown in each of his five previous appearances with the Buccaneers as road favorites.
• Baker Mayfield has recorded 235+ passing yards in each of his last six December appearances with his team as a road favorite.
• Baker Mayfield has recorded 21+ completions in each of his last five Week 16 appearances.
• Jalen McMillan has recorded 11+ receiving yards in each of his last 11 appearances.
• Chris Godwin has recorded 45+ rushing and receiving yards in each of his last 10 road appearances on the East Coast.
• Rachaad White has recorded 20+ rushing yards in each of the Buccaneers’ last eight December games against NFC South opponents.
• Heading into Week 16, Chase McLaughlin ranks 1st in the NFL in 50+ yard field goals made (10) this season.

Matchup/League Facts

• Panthers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 16.
• Heading into Week 16, the Panthers are the only team to overturn multiple 12+ point 2nd quarter deficits to win this season.
• Heading into Week 16, 11 different Buccaneers players have recorded a receiving touchdown this season – equal-most in the league.
• Heading into Week 16, the Buccaneers have lost the fourth quarter in each of their last five games – longest active streak in the league.

Buccaneers vs Panthers Prediction

In this Buccaneers vs Panthers Prediction, the Buccaneers are coming as -3-point road favorites. Both teams have identical overall records this season and both have four home/away wins. Neither team is coming into this matchup in good form, as the Panthers are alternating wins and losses for the past 8 games, while the Buccaneers are 1-5 in their last 6 games and 0-6 against the spread. Tampa has a superior offense, scoring 4.5 points per game more than the Panthers and has been dominating them in Carolina, as they are 4-1 in their last 5 visits there. I expect the guests to get the job done, so take the Buccaneers and lay the -3 on the road.

Nikos Lagouretos's Pick: Tampa Bay Buccaneers -3