San Francisco 49ers vs Cleveland Browns Prediction 11/30/2025 Today’s NFL Picks

In this article, we will formulate a 49ers vs Browns Prediction for this NFL Week 13 game on Sunday, November 30th. Let’s take a look at the prediction for this NFL matchup.

Cleveland Browns Preview

The Cleveland Browns have a 3-8 record this season and are sitting third in the AFC North. They are 5-6 ATS, 6-5 in Over/Under and have a 2-3 home record and a 1-5 away record. The Browns are coming off a 24-10 away win against the Las Vegas Raiders and will face the Titans and Bears next.

Offensively, the Browns average 16.9 points per game, ranking 29th in the NFL, while defensively, they allow 22.2 points per game, which is 13th. Cleveland averages 258.5 total yards per game (163.5 passing and 94.9 rushing), while allowing 273.0 total yards per game (102.3 rushing and 170.7 passing).

Dillon Gabriel leads the Browns with 937 passing yards with 59.2% completed passes and seven touchdowns. Quinshon Judkins leads the team in rushing yards with 667, while Harold Fannin has a team-high 48 receptions for 462 receiving yards, and two touchdowns. Defensively, Carson Schwesinger has a team-high 96 total tackles (44 of them solo), while Myles Garrett leads the team in sacks, with 18.

San Francisco 49ers Preview

The San Francisco 49ers have an 8-4 record this season and are sitting third in the NFC West. They are 7-5 ATS, 7-4-1 in Over/Under and have a 3-2 home record and a 5-2 away record. The 49ers are coming off a 20-9 home win against the Carolina Panthers and will face the Titans and Colts next.

Offensively, the 49ers average 23.4 points per game, ranking 15th in the NFL, while defensively, they allow 21.8 points per game, which is 11th. San Francisco averages 348.6 total yards per game (249.4 passing and 99.2 rushing), while allowing 342.7 total yards per game (100.9 rushing and 241.8 passing).

Mac Jones leads the 49ers with 2151 passing yards with 69.6% completed passes and 13 touchdowns. Christian McCaffrey leads the team in rushing yards with 796, while Christian McCaffrey has a team-high 81 receptions for 785 receiving yards, and five touchdowns. Defensively, Dee Winters has a team-high 78 total tackles (53 of them solo), while Bryce Huff leads the team in sacks, with 4.

San Francisco 49ers @ Cleveland Browns Betting Trends: Week 13

Why the Cleveland Browns will win

• The 49ers have lost each of their last three games as favorites against AFC opponents.
• The home team has won eight of the last nine games between the 49ers and Browns.
• The 49ers have failed to cover the spread in 15 of their last 17 games following a win.
• The Browns have covered the spread in each of their last four games at Huntington Bank Field.
• The Browns have scored the first touchdown in seven of their last eight games.
• The Browns have won the first quarter in each of their last three November games as underdogs against NFC opponents.
• The home team has won the first half in eight of the last nine games between the 49ers and Browns.

Why the San Francisco 49ers will win

• The 49ers have won each of their last seven games against starting rookie QBs.
• The Browns have lost each of their last six games following a win.
• The Browns have failed to cover the spread in each of their last six games following a win.
• The favorites have covered the spread in each of the 49ers’ last five games.
• The Browns have lost the first quarter in each of their last five Week 13 games against NFC opponents.
• The Browns have lost the first half in each of their last 12 games as underdogs following a win.
• The 49ers have scored the first touchdown in seven of their last eight games as road favorites.

Total Points Facts

• Each of the 49ers’ last four Week 13 games as favorites have gone OVER the total points line.
• Six of the Browns’ last seven games against NFC West opponents have gone OVER the total points line.

Cleveland Browns Player Prop Facts

• David Njoku has scored a touchdown in four of the Browns’ last five games as underdogs following a road win.
• Deshaun Watson has recorded 275+ passing yards in five of his last six appearances with his team as a home underdog.
• Deshaun Watson has recorded 26+ rushing yards in each of his last seven appearances with his team as an underdog following a win.
• Quinshon Judkins has recorded 95+ rushing and receiving yards in each of the Browns’ last three games against NFC opponents.
• David Njoku has recorded 29+ receiving yards in 14 of his last 15 appearances following a win.
• Deshaun Watson has recorded 25+ completions in five of his last six appearances with his team as a home underdog.
• Heading into Week 13, Myles Garrett ranks 1st in the NFL in sacks (18.0) this season.

San Francisco 49ers Player Prop Facts

• Christian McCaffrey has scored two or more touchdowns in three of the 49ers’ last four November games as road favorites.
• Christian McCaffrey has scored the first touchdown in three of his four previous road appearances against AFC North opponents.
• Brock Purdy has recorded 18+ completions in each of his last eight regular season appearances with the 49ers as road favorites.
• Brock Purdy has recorded 230+ passing yards in nine of his last 10 regular season appearances with the 49ers as road favorites.
• Christian McCaffrey has recorded 118+ rushing and receiving yards in eight of his last nine appearances with the 49ers as favorites against AFC opponents.
• Christian McCaffrey has scored at least one touchdown in each of his last eight appearances against AFC North opponents.
• Demarcus Robinson has recorded 17+ receiving yards in each of his last six November appearances against AFC opponents.
• Brock Purdy has recorded 11+ rushing yards in 14 of his last 15 Sunday appearances with the 49ers as favorites.
• Heading into Week 13, Christian McCaffrey is the only player in the NFL to record 5+ rushing and 5+ receiving TDs this season.

Matchup/League Facts

• Heading into Week 13, the Browns rank 1st in the NFL in total punt yards (2870) this season.
• Heading into Week 13, the Browns have suffered the equal-most road losses by a margin of 10+ points this season (4).
• Heading into Week 13, the 49ers rank 32nd in the NFL in sacks (13.0) this season.
• Heading into Week 13, the 49ers rank 1st in the NFL in 1st downs (263) this season.

49ers vs Browns Prediction

In this 49ers vs Browns Prediction, the 49ers are coming as -5-point road favorites. The 49ers have been the far better team with more than twice wins than the Browns and have also been better on the road, with 5 of their 8 wins this season coming away from home. The 49ers are 3-1 both straight up and against the spread in their last 4 games, while on the other hand, the Browns are 2-6 in their last 8. Cleveland has the 4th-worst offense in the NFL and I expect the better road team to take care of business in this one. Take the 49ers and lay the -5 on the road.

Nikos Lagouretos's Pick: 49ers -5