Los Angeles Chargers vs Dallas Cowboys Prediction 12/21/2025 Today’s NFL Picks

The Los Angeles Chargers and Dallas Cowboys meet Sunday in NFL action at AT&T Stadium. Here’s a Los Angeles Chargers vs Dallas Cowboys Prediction. This article will include a Los Angeles Chargers vs Dallas Cowboys Pick.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers beat the Chiefs and Eagles, and they play the Texans next. The Los Angeles Chargers have won 6 of their last 7 games. Justin Herbert is completing 65.6 percent of his passes for 3,191 yards, 23 touchdowns, and 12 interceptions. Ladd McConkey and Keenan Allen have combined for 1,395 receiving yards and 9 touchdowns, while Oronde Gadsden II has 43 receptions.

The Los Angeles Chargers ground game is averaging 123.4 yards per contest, and Kimani Vidal leads the way with 620 yards and 3 touchdowns. Defensively, Los Angeles is allowing 20.3 points and 279.1 yards per game. Daiyan Henley leads the Los Angeles Chargers with 86 tackles, Tuli Tuipulotu has 12 sacks and Tony Jefferson has 4 interceptions.

Dallas Cowboys Betting Preview

The Dallas Cowboys lost to the Lions and Vikings, and they play the Commanders next. The Dallas Cowboys have lost 2 straight games. Dak Prescott is completing 68.4 percent of his passes for 3,931 yards, 26 touchdowns, and 10 interceptions. George Pickens and CeeDee Lamb have combined for 2,188 receiving yards and 11 touchdowns, while Jake Ferguson has 77 receptions.

The Dallas Cowboys ground game is averaging 120.8 yards per contest, and Javonte Williams leads the way with 1,113 yards and 10 touchdowns. Defensively, Dallas is allowing 30 points and 374.9 yards per game. Kenneth Murray Jr. leads the Dallas Cowboys with 74 tackles, James Houston has 5.5 sacks and Donovan Wilson has 2 interceptions.

Why the Dallas Cowboys will win

• The home team has won 10 of the Cowboys’ last 11 Week 16 games.
• The Chargers have lost each of their last four games without Justin Herbert.
• The Cowboys have covered the spread in each of their last five home games against teams that held a winning record.
• The Chargers have failed to cover the spread in four of their last five Sunday road games.
• The Chargers have lost the first half in four of their last five road games.
• The home team has won the first quarter in six of the Chargers’ last seven games.

Why the Los Angeles Chargers will win

• The Chargers have won four of their last five games as underdogs.
• The Cowboys have lost each of their last two games as favorites without CeeDee Lamb.
• The Cowboys have failed to cover the spread in each of their last six home games without DaRon Bland.
• The Chargers have covered the spread in nine of their last 10 games as road underdogs against NFC opponents.
• The Chargers have won the first quarter in five of their last seven games as underdogs following a road win.
• The Cowboys have lost the first half in six of their last eight home games against AFC West opponents.

Total Points Facts

• Each of the Chargers’ last seven Sunday games as road underdogs have gone UNDER the total points line.
• Seven of the Cowboys’ last eight Sunday games as home favorites have gone OVER the total points line.

Dallas Cowboys Player Prop Facts

• CeeDee Lamb has scored a touchdown in four of the Cowboys’ last five games as favorites against teams that held a winning record.
• Dak Prescott has recorded 250+ passing yards in each of his last 15 regular season appearances with the Cowboys as home favorites.
• Dak Prescott has recorded 24+ completions in 13 of the Cowboys’ last 15 Sunday games as favorites.
• Javonte Williams has recorded 91+ rushing and receiving yards in each of his six previous Sunday appearances at AT&T Stadium.
• Javonte Williams has recorded 83+ rushing yards in each of the Cowboys’ last six games following a loss.
• Javonte Williams has recorded 13+ receiving yards in each of his last six home appearances against AFC West opponents.
• Heading into Week 16, Javonte Williams ranks T1st in the NFL in broken tackles (24) this season.

Los Angeles Chargers Player Prop Facts

• Justin Herbert has recorded 23+ completions in each of the Chargers’ last three road games against NFC East opponents.
• Quentin Johnston has scored a touchdown in each of his last three appearances in day games against teams that held a losing record.
• Justin Herbert has recorded 24+ rushing yards in each of the Chargers’ last four games against NFC opponents.
• Keenan Allen has recorded 34+ receiving yards in each of his last 37 Sunday regular season appearances with the Chargers as underdogs.
• Omarion Hampton has recorded 65+ rushing and receiving yards in each of his four previous Sunday appearances.
• Justin Herbert has been sacked 49 times this season – equal-most in the league.

Matchup/League Facts

• Heading into Week 16, the Cowboys rank 32nd in the NFL in passing yards allowed per game (254.8) this season.
• Heading into Week 16, the Cowboys rank 32nd in the NFL in punt return yards per game (5.9) this season.
• Chargers – two different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 16.
• Heading into Week 16, the Chargers rank 1st in the NFL in time of possession per game (33:20) this season.

Los Angeles Chargers vs Dallas Cowboys Prediction

Right when it looked like the Cowboys were turning the corner, the defense goes back to being trash, and now they’re all but out of the playoff race. The Cowboys are 29th in total defense and 31st in scoring defense. The Chargers are getting healthier on offense, and the defense is one of the more underrated units in the NFL. The Chargers are second in total defense and ninth in scoring defense. The Chargers are a good football team that can enter Super Bowl contender status if the offensive line eventually gets right.

I have zero idea why the Cowboys are favorites in this game. It makes zero sense. The Cowboys are 4-8 ATS in their last 12 games as a favorite. The Chargers are 3-0 SU this season as an underdog. This line is Looney Tunes stuff. Give me the Chargers ML.

Randy Chambers's Pick: Los Angeles Chargers ML