Jacksonville Jaguars vs Arizona Cardinals Prediction 11/23/2025 Today’s NFL Picks

In this article, we will formulate a Jaguars vs Cardinals Prediction for this NFL Week 12 game on Sunday, November 23rd. Let’s take a look at the prediction for this NFL matchup.

Arizona Cardinals Preview

The Arizona Cardinals have a 3-7 record this season and are sitting fourth in the NFC West. They are 5-5 ATS, 6-4 in Over/Under and have a 1-4 home record and a 2-3 away record. The Cardinals are coming off a 22-41 home loss against the San Francisco 49ers and will face the Buccaneers, Rams and Texans next.

Offensively, the Cardinals average 22.4 points per game, ranking 19th in the NFL, while defensively, they allow 25.6 points per game, which is 25th. Arizona averages 333.5 total yards per game (227.8 passing and 105.7 rushing), while allowing 333.6 total yards per game (112.2 rushing and 221.4 passing).

Jacoby Brissett leads the Cardinals with 1570 passing yards with 66.7% completed passes and 10 touchdowns. Emari Demercado leads the team in rushing yards with 241, while Trey McBride has a team-high 71 receptions for 718 receiving yards, and seven touchdowns. Defensively, Budda Baker has a team-high 69 total tackles (31 of them solo), while Josh Sweat leads the team in sacks, with 9.0, while Denzel Burke and Dadrion Taylor-Demerson each have two interceptions.

Jacksonville Jaguars Preview

The Jacksonville Jaguars have a 6-4 record this season and are sitting second in the AFC South. They are 5-4-1 ATS, 5-5-0 in Over/Under and have a 4-2 home record and a 2-2 away record. The Jaguars are coming off a 35-6 home win against the Los Angeles Chargers and will face the Titans and Colts next.

Offensively, the Jaguars average 24.0 points per game, ranking 13th in the NFL, while defensively, they allow 22.6 points per game, which is 12th. Jacksonville averages 326.9 total yards per game (199.4 passing and 127.5 rushing), while allowing 323.6 total yards per game (86.7 rushing and 236.9 passing).

Trevor Lawrence leads the Jaguars with 2151 passing yards with 59.8% completed passes and 11 touchdowns. Travis Etienne leads the team in rushing yards with 729, while Brian Thomas has a team-high 30 receptions for 420 receiving yards, and one touchdown. Defensively, Foyesade Oluokun has a team-high 80 total tackles (38 of them solo), while Arik Armstead leads the team in sacks, with 5.5, while Devin Lloyd has four interceptions.

Jacksonville Jaguars @ Arizona Cardinals Betting Trends: Week 12

Why the Arizona Cardinals will win

• The Jaguars have lost each of their last nine games against NFC opponents on a losing streak.
• The Cardinals have won three of their last four games as underdogs against AFC opponents.
• The Cardinals have covered the spread in each of their last seven games as underdogs against AFC opponents.
• The Jaguars have failed to cover the spread in eight of their last nine games against NFC West opponents.
• The Cardinals have scored the first touchdown in nine of their last 10 Sunday home games.
• The Jaguars have lost the first half in seven of their last eight November games against NFC opponents.
• The Cardinals have won the first quarter in each of their last four Week 12 games as underdogs.

Why the Jacksonville Jaguars will win

• The Cardinals have lost each of their last nine games against teams that held a winning record.
• The road team has won four of the last five games between the Jaguars and Cardinals.
• The road team has covered the spread in eight of the Cardinals’ last 10 games.
• The Cardinals have failed to cover the spread in four of their last five home games.
• The Cardinals have lost the first half in seven of their last eight games against teams that held a winning record.
• The road team has won the first quarter in each of the Jaguars’ last four Week 12 games.
• The Jaguars have scored the first touchdown in four of their last five games following a win.

Total Points Facts

• Each of the Cardinals’ last seven Sunday home games have gone OVER the total points line.
• Ten of the Jaguars’ last 11 games following a win have gone OVER the total points line.
• Seventeen of the last 21 Sunday games at State Farm Stadium have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 258+ passing yards in each of the Cardinals’ last five games.
• Trey McBride has scored at least one touchdown in each of the Cardinals’ last six day games against teams that held a winning record.
• Michael Carter has recorded 10+ receiving yards in eight of his last nine home appearances against AFC opponents.
• Michael Carter has recorded 34+ rushing yards in five of his six previous appearances against AFC South opponents.
• Michael Carter has recorded 24+ rushing and receiving yards in each of his seven previous November home appearances.
• Jacoby Brissett has recorded 22+ completions in each of the Cardinals’ last four Sunday games.
• Heading into Week 12, Jacoby Brissett has recorded the most completions in a single game this season (47 vs 49ers, Week 11).

Jacksonville Jaguars Player Prop Facts

• Jakobi Meyers has scored a touchdown in seven of his last eight appearances with his team as a favorite against NFC opponents.
• Trevor Lawrence has recorded 211+ passing yards in each of the Jaguars’ last seven games as slight favorites (<-3.5 points).
• Trevor Lawrence has recorded 17+ rushing yards in four of the Jaguars’ last five games as slight favorites (<-3.5 points).
• Dyami Brown has recorded 13+ receiving yards in each of his last 10 appearances against NFC opponents.
• Jakobi Meyers has recorded 52+ rushing and receiving yards in each of his six previous Week 12 appearances.
• Trevor Lawrence has recorded 20+ completions in each of the Jaguars’ last seven games as favorites following a win.
• Heading into Week 12, Devin Lloyd has recorded the equal-most interceptions in a single game this season (2 vs 49ers, Week 4).

Matchup/League Facts

• Cardinals – four different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 12.
• Heading into Week 12, the Cardinals have suffered the equal-most losses when leading after Q3 this season (4).
• Heading into Week 12, the Jaguars rank 1st in the NFL in average punt return (16.6 yards) this season.
• Heading into Week 12, the Jaguars rank 1st in the NFL in time of possession per game (32:45) this season.

Jaguars vs Cardinals Prediction

The Cardinals have won all of their four meetings against the Jaguars and the over is 3-1 in those four games.

In this Jaguars vs Cardinals Prediction, the Jaguars are coming as -2.5-point road favorites. The Cardinals have been on a free fall lately, with a 1-7 record in their last 8 games and they have been weaker than the Jaguars both offensively and defensively. They have been also terrible at home, with just one win in five home games this season, so I like the value with the road team in this matchup. Take the Jaguars and lay the -2.5 on the road.

Nikos Lagouretos's Pick: Jaguars -2.5