Indianapolis Colts vs Seattle Seahawks Prediction 12/14/2025 Today’s NFL Picks

The Indianapolis Colts and the Seattle Seahawks meet in week 15 NFL action from Lumen Field on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indianapolis Colts vs. Seattle Seahawks prediction.

Indianapolis Colts Recap

The Indianapolis Colts come into this game looking to bounce back from a 36-19 loss at the hands of Jacksonville last time out to sit at 8-5 this season. After this game, Indianapolis will take on San Francisco at home.

Colts Lose 3 In A Row

Philip Rivers will start at QB here after Indianapolis lost Daniel Jones for the year and Riley Leonard suffered a potential injury as well. Jonathan Taylor has rushed for 1,356 yards and 16 touchdowns to lead the Colts on the ground while Tyler Warren has 60 catches for 699 yards and Michael Pittman Jr. has 69 grabs for 699 receiving yards and 7 touchdowns. Alec Pierce also has 769 receiving yards and Josh Downs has 393 receiving yards as well this season. On defense, Zaire Franklin has a team-high 94 total tackles with 45 solo tackles while Cam Bynum and Laiatu Latu each have a team-high 3 interceptions for the Colts’ defense so far this season. Latu also has a team-high 5.5 sacks while DeForest Buckner and Kwity Paye each have 4 sacks as well this year. As a unit, Indianapolis’ defense has combined for 35 sacks and 12 interceptions so far this season.

Seattle Seahawks Recap

The Seattle Seahawks come into this game looking to add on to their 37-9 win over Atlanta last time out to sit at 10-3 this season. After this game, Seattle will take on the Los Angeles Rams at home.

Seahawks Win 3 Straight

Sam Darnold has thrown for 3,162 yards, 22 touchdowns and 11 interceptions on 68.1% passing while Kenneth Walker III has 762 rushing yards with 4 touchdowns to lead Seattle and Zach Charbonnet has 483 rushing yards with 8 touchdowns. Jaxon Smith-Njigba leads the Seahawks in receiving with 89 catches for 1,428 yards and 9 touchdowns while Cooper Kupp has 463 receiving yards and AJ Barner has 386 receiving yards with 4 TDs. On defense, Ernest Jones IV leads the Seahawks with 94 total tackles along with 5 interceptions while Leonard Williams and Byron Murphy II each have a team-high 7 sacks. Uchenna Nwosu has 6 sacks and DeMarcus Lawrence has 5 sacks. As a unit, Seattle’s defense has combined for 41 sacks and 15 interceptions so far this season.

Indianapolis Colts @ Seattle Seahawks Betting Trends: Week 15

Why the Seattle Seahawks will win

• The Colts have lost each of their last 10 games as underdogs against NFC opponents.
• The home team has won each of the Colts’ last seven Week 15 games.
• The Colts have failed to cover the spread in each of their last seven games as underdogs against NFC opponents.
• The Seahawks have covered the spread in seven of their last eight games.
• The favorites have won the first half in seven of the Seahawks’ last eight games.
• The Seahawks have scored the first touchdown in each of their last six games as favorites.
• The Colts have won the first quarter in two of their last three games as heavy underdogs (>+7.0 points).

Why the Indianapolis Colts will win

• The Colts have won four of their last five games as road underdogs following a Division loss.
• The Seahawks have lost each of their last three December games as home favorites.
• The Seahawks have failed to cover the spread in seven of their last eight games as favorites without Uchenna Nwosu.
• The Colts have covered the spread in each of their last four games without Jonathan Taylor.
• The Seahawks have lost the first half in each of their last six home games in December.
• The Colts have scored the first touchdown in each of their last 10 games as road underdogs.
• The Seahawks have lost the first quarter in each of their last six home games in December.

Total Points Facts

• Each of the Colts’ last six games in December have gone OVER the total points line.
• Each of the Seahawks’ last five Week 15 games have gone UNDER the total points line.
• Three of the last four Sunday games at Lumen Field have gone OVER the total points line.

Seattle Seahawks Player Prop Facts

• Sam Darnold has recorded 231+ passing yards in each of his last six December appearances.
• Cooper Kupp has recorded 33+ receiving yards in 11 of his 12 previous December home appearances.
• Zach Charbonnet has recorded 47+ rushing yards in seven of his last eight appearances following a road win.
• Sam Darnold has recorded 20+ completions in each of his last six December appearances.
• Zach Charbonnet has scored at least one touchdown in seven of his last eight appearances following a road win.
• Cooper Kupp has recorded 33+ rushing and receiving yards in 11 of his 12 previous December home appearances.
• Heading into Week 15, Jaxon Smith-Njigba ranks 1st in the NFL in receiving yards (1428) this season.

Indianapolis Colts Player Prop Facts

• Jonathan Taylor has recorded 96+ rushing yards in five of the Colts’ last six December games.
• Philip Rivers has recorded 160+ passing yards in each of his last 106 appearances.
• Michael Pittman Jr. has recorded 42+ receiving yards in each of his last seven December road appearances.
• Jonathan Taylor has recorded 96+ rushing and receiving yards in each of the Colts’ last six games played on the West Coast.
• Philip Rivers has recorded 17+ completions in each of his last 23 appearances with his team as an underdog following a loss.
• Jonathan Taylor has scored at least one touchdown in six of the Colts’ last seven December games.
• Heading into Week 15, Jonathan Taylor ranks 1st in the NFL in rushing yards (1356) this season.

Matchup/League Facts

• Seahawks – six different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 15.
• Seahawks – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 15.
• Heading into Week 15, the Colts rank 32nd in the NFL in total punt yards (1535) this season.
• Heading into Week 15, the Colts have played in the equal-highest number of games that went to overtime this season (2).

Indianapolis Colts vs. Seattle Seahawks Prediction

I’m on the Colts and the points here. I get the case to be made for Seattle being favored at home here as the Seahawks have been dismantling teams left and right this season. However, Philip Rivers is no slouch, and he’s been staying active in the sport even with his time since retiring. I get that it’s not game action, but it’s better than just coming in rusty and with no experience. The Colts also have a serious run game and massive underdogs in the NFL have covered at a fairly high rate in recent years. Give me the Colts and the boatload of points here.

Chris Ruffolo's Pick: Indianapolis +13.5