Indianapolis Colts vs Los Angeles Chargers Prediction 10/19/2025 Today’s NFL Picks

The Indianapolis Colts and the Los Angeles Chargers meet in week 7 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indianapolis Colts vs. Los Angeles Chargers prediction.

Indianapolis Colts Recap

The Indianapolis Colts come into this game looking to add on to their 5-1 start to the year thanks to a 31-27 win over Arizona last time out. After this game, Indianapolis will head home for a game against the Tennessee Titans.

Colts Win Back-To-Back Games

Daniel Jones has thrown for 1,502 yards, 8 touchdowns and 3 interceptions on 71.7% passing while also rushing for 4 TDs as well this season. Jonathan Taylor has rushed for 603 yards and 7 touchdowns to lead the Colts on the ground while Tyler Warren has 29 catches for 370 yards and Michael Pittman Jr. has 28 grabs for 293 receiving yards and 4 touchdowns. Alec Pierce also has 219 receiving yards and Josh Downs has 217 receiving yards as well this season. On defense, Nick Cross has a team-high 47 total tackles with 27 solo tackles while Cam Bynum, Laiatu Latu and Mekhi Blackmon each have a pair of interceptions for the Colts’ defense so far this season. Kwity Paye and Tyquan Lewis each have 3 sacks as well this year. As a unit, Indianapolis’ defense has combined for 16 sacks and 7 interceptions so far this season.

Los Angeles Chargers Recap

The Los Angeles Chargers come looking to add on to their 29-27 win over Miami last time out to improve to 4-2 this season. After this game, the Chargers will head home for a game against the Minnesota Vikings.

Chargers Snap Two-Game Slide

Justin Herbert has thrown for 1,493 yards, 10 touchdowns and 4 interceptions on 67.6% passing while Omarion Hampton leads Los Angeles in rushing with 314 rushing yards and 2 TDs this season. Quentin Johnston has 377 receiving yards and 4 touchdowns to lead the Chargers’ group while Keenan Allen has 33 catches for 316 receiving yards and 3 touchdowns and Ladd McConkey’s added 28 catches and 313 receiving yards as well. On defense, Daiyan Henley has a team-high 46 total tackles and a pair of sacks while Derwin James Jr. has 37 total tackles including a team-high 25 solo tackles. Tuli Tuipulotu has a team-high 5 sacks while the Chargers’ defensive unit as a whole has combined for 16 sacks and 6 interceptions so far this season. 

Indianapolis Colts @ Los Angeles Chargers Betting Trends: Week 7

Why the Los Angeles Chargers will win

• The home team has won nine of the Colts’ last 10 games.
• The Colts have lost seven of their last eight road games following a win.
• The Chargers have covered the spread in each of their last five games as home favorites against AFC opponents.
• The Colts have failed to cover the spread in five of their last six games against teams that held a winning record.
• The Chargers have won the first quarter in each of their last two games against teams that held a winning record.
• The favorites have won the first half in each of the Colts’ last seven games.
• The Chargers have scored the first touchdown in each of their last three games played on the West Coast.

Why the Indianapolis Colts will win

• The Colts have won each of their last six games against AFC opponents.
• The Chargers have lost three of their last four games as favorites against AFC South opponents.
• The Colts have covered the spread in each of their last six October games against AFC opponents.
• The Chargers have failed to cover the spread in five of their last six Week 7 games.
• The Colts have won the first quarter in five of their last six October games as underdogs against AFC opponents.
• The Colts have won the first half in six of their last seven games against AFC opponents.
• The Colts have scored the first touchdown in each of their last eight games as road underdogs.

Total Points Facts

• Eight of the Colts’ last nine Sunday games played on the West Coast have gone OVER the total points line.
• Each of the Chargers’ last five home games in October have gone UNDER the total points line.
• Each of the last four Sunday games at SoFi Stadium have gone UNDER the total points line.

Los Angeles Chargers Player Prop Facts

• Ladd McConkey has scored at least one touchdown in each of the Chargers’ last three October games.
• Justin Herbert has recorded 20+ rushing yards in five of the Chargers’ last six October home games.
• Justin Herbert has recorded 25+ completions in five of the Chargers’ last six regular season games against AFC opponents.
• Justin Herbert has recorded 259+ passing yards in each of the Chargers’ last four Week 7 games.
• Will Dissly has recorded 24+ receiving yards in each of his last five appearances at SoFi Stadium.
• Ladd McConkey has recorded 74+ rushing and receiving yards in eight of his last 10 appearances against AFC opponents.
• Heading into Week 7, Tuli Tuipulotu has recorded the most sacks in a single game this season (4.0 vs Giants, Week 4).

Indianapolis Colts Player Prop Facts

• Tyler Warren has scored the first touchdown in each of the Colts’ last three games.
• Daniel Jones has recorded 20+ rushing yards in each of his five previous Week 7 appearances.
• Daniel Jones has recorded 22+ completions in each of his last six appearances with his team as an underdog following a win.
• Daniel Jones has recorded 236+ passing yards in each of his last four appearances with his team as a road underdog.
• Jonathan Taylor has scored at least one touchdown in eight of his last nine appearances following a home win.
• Jonathan Taylor has scored the last touchdown in each of the Colts’ last three October games.
• Michael Pittman Jr. has recorded 58+ receiving yards in each of the Colts’ last four Week 7 games.
• Jonathan Taylor has recorded 108+ rushing and receiving yards in seven of his last eight appearances following a home win.
• Heading into Week 7, Jonathan Taylor ranks 1st in the NFL in rushing yards (603) this season.

Matchup/League Facts

• Chargers – three different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
• Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
• Colts – seven different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 7.
• Heading into Week 7, the Colts rank 1st in the NFL in points per game (32.3) this season.

Indianapolis Colts vs. Los Angeles Chargers Prediction

I’m on the Chargers here. I’m still waiting for the other shoe to drop with the Colts, who I think are in a bit of a sell-high spot after a close call against the Cardinals last week. The same could be said for the Chargers, who were lucky to get out alive against the Miami Dolphins, but I think the Chargers are a better team than they showed in the two games prior to last week’s win, and still have a top-tier defense that can get after Daniel Jones, who is playing above his pay grade in my opinion. Give me the Chargers here.

Chris Ruffolo's Pick: Los Angeles Chargers -1.5