Cleveland Cavaliers vs Boston Celtics Prediction 10/29/2025 Today’s NBA Picks

The Cleveland Cavaliers travel to the TD Garden to take on the Boston Celtics on Wednesday night. Here’s a Celtics vs Cavaliers Prediction. This article will include a Celtics vs Cavaliers Prediction Pick.

Cleveland Cavaliers Betting Preview 

The Cleveland Cavaliers are starting to heat up now as they will be aiming for a fourth straight victory after smashing the Pistons in a 116-95 road win on Monday. Donovan Mitchell led the team with 35 points on 13 of 18 shooting, Jarrett Allen added 20 points on seven of 12 shooting, Evan Mobley tallied 15 points with 11 rebounds and five assists, while De’Andre Hunter chipped in with 13 points, five rebounds and six assists.

As a team, the Cavaliers shot 45 percent from the field and 11 of 35 from the 3-point line as they jumped all over the Pistons from the start and were always in control after winning the first half by 63-41. The Cavaliers actually led by as many as 35 points in this one before they started resting their starters early. 

Boston Celtics Betting Preview 

Meanwhile, the Boston Celtics will be feeling much better after snapping a three-game skid with a 122-90 road win over the Pelicans on Monday. Anfernee Simons led the team with 25 points on nine of 17 shooting off the bench. Payton Pritchard added 18 points with eight assists, while Jaylen Brown chipped in with just 15 points in 24 minutes of action as he was hampered by a hamstring injury.

As a team, the Celtics shot 48 percent from the field and 18 of 53 from the 3-point line as they set the tone with 34 points in the first quarter to take an 11-point lead into halftime. Before they absolutely dominated the fourth quarter by 35-12 to finally get their first win of the season.

Why the Boston Celtics will win

• The Celtics have won four of their last five games as home underdogs against Eastern Conference opponents.
• The Cavaliers have lost each of their last six Wednesday night games at TD Garden.
• The Cavaliers have failed to cover the spread in five of their last six games.
• The underdogs have covered the spread in five of the last six games between the Cavaliers and Celtics.

Why the Cleveland Cavaliers will win

• The Cavaliers have won 20 of their last 21 night games against Eastern Conference opponents that held a losing record.
• The Celtics have lost six of their last seven night games against Eastern Conference opponents.
• The Celtics have failed to cover the spread in eight of their last nine night games against Eastern Conference opponents that held a winning record.
• The Cavaliers have covered the spread in each of their last four road games against the Celtics.

Total Points Facts

• Eight of the Celtics’ last nine games as underdogs have gone UNDER the total points line.
• Eight of the Cavaliers’ last 10 road games following a road win have gone OVER the total points line.

Boston Celtics Player Facts

• Sam Hauser ranks 10th amongst qualified players for three-pointers made per 36 minutes (4.7) this season.
• Payton Pritchard ranks T15th in the Eastern Conference amongst qualified players for assists per game (5.0) this season.

Cleveland Cavaliers Player Facts

• Lonzo Ball ranks 8th amongst qualified players for assists per 36 minutes (9.9) this season.
• Dean Wade is one of only 22 qualified Centers in the league shooting at least 30% from three this season.

Matchup/League Facts

• The Celtics rank 30th in the league for opponent offensive rebounds per game this season (15.3).
• The Celtics rank 1st in the league for opponent field goal percentage this season (39.9%).
• The Cavaliers rank T2nd in the league for H1 win percentage this season (75.0%).
• The Cavaliers rank T28th in the league for offensive rebounds per game this season (8.8).

Celtics vs Cavaliers Prediction

The Cavaliers are still missing Max Strus, Darius Garland and now Sam Merrill, while the Celtics have decided to list Jaylen Brown as probable despite his hamstring niggle. The Cavaliers look to be building nicely with three wins on the trot and they were dominant in their big win over the Pistons. Meanwhile, the Celtics were able to avoid a fourth straight defeat with an easy win over the Pelicans.

I wouldn’t be surprised if the Celtics pulled off the upset at home, but the Cavaliers are certainly playing better at this early stage of the season, and I think they get the job done at the short line.