Toronto Blue Jays vs Baltimore Orioles Prediction 9/22/2026 Today’s MLB Picks

In this article, we will formulate a Blue Jays vs Orioles Prediction for this MLB matchup on Tuesday, September 22nd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Preview

The Baltimore Orioles have a 76-81 record this season and are sitting in the 5th place of the AL East. They have a 37-42 home record and are coming off a 4-3 home win against the Blue Jays. They will face the Yankees next.

The Baltimore Orioles have a .234 batting average this season, .314 OBP and .395 Slugging percentage. Baltimore’s pitching staff has a 4.11 ERA and 1.34 WHIP. Pete Alonso is the team’s best hitter with a .265 batting average, leading the team in RBI with 108 and adding a team-high 40 home runs.

Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 8-5 record, 4.64 ERA and 1.55 WHIP.

Toronto Blue Jays Preview

The Toronto Blue Jays have a 77-80 record this season and are sitting in the 4th place of the AL East. They have a 37-42 away record and are coming off a 3-4 road loss against the Orioles. They will face the Reds next.

The Toronto Blue Jays have a .248 batting average this season, .310 OBP and .382 Slugging percentage. Toronto’s pitching staff has a 3.92 ERA and 1.30 WHIP. Ernie Clement is the team’s best hitter with a .264 batting average. Kazuma Okamoto leads the team in RBI with 89, adding a team-high 33 home runs.

Max Scherzer (R) is the projected starting pitcher for the Blue Jays, and he has a 3-8 record, 6.07 ERA and 1.36 WHIP.

Toronto Blue Jays @ Baltimore Orioles Betting Trends: September 22, 2026

• Probable Starting Pitcher: Chris Bassitt      Record this season: 8-5      ERA: 4.64
• Home Record: 3-2
• Last 5 against Blue Jays: 1-1

Why the Baltimore Orioles will win

• The Blue Jays have lost each of their last six night games against AL opponents.
• The Orioles have won 10 of their last 11 night games against teams that held a losing record.
• The Blue Jays have failed to cover the run line in each of their last six night games against AL opponents.
• The Orioles have covered the run line in seven of their last eight home games against AL opponents that held a losing record.
• The Orioles have led after 5 innings in four of their last five games as favorites against AL opponents.
• The Orioles have led after 3 innings in four of their last five night games against AL opponents that held a losing record.

• Probable Starting Pitcher: Max Scherzer      Record this season: 3-8      ERA: 6.07
• Road Record: 0-1
• Last 5 against Orioles: 0-3

Why the Toronto Blue Jays will win

• The Blue Jays have won 10 of their last 11 games as underdogs following a loss.
• The Orioles have lost five of their last six games as favorites against AL East opponents following a home win.
• The Blue Jays have covered the run line in 10 of their last 11 games as underdogs following a loss.
• The Orioles have failed to cover the run line in five of their last six games as favorites.
• The Blue Jays have led after 5 innings in each of their last four road games against AL East opponents that held a losing record.
• The Blue Jays have led after 3 innings in each of their last four road games against AL East opponents that held a losing record.
• The Orioles have lost the first inning in each of their last three home games against AL opponents.

Total Runs Facts

• Nine of the last 10 games between the Blue Jays and Orioles have gone OVER the total runs line.
• Seven of the Blue Jays’ last eight games as underdogs against the Orioles have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of Max Scherzer’s last eight appearances as a starter.
• There has been at least one run scored in the first inning in each of the Orioles’ last four night games against AL opponents.

Baltimore Orioles Player Prop Facts

• Pete Alonso has hit at least one home run in four of the Orioles’ last five night games.
• Chris Bassitt has recorded four or more strikeouts in 28 of his last 29 home appearances against AL opponents that held a losing record.
• Pete Alonso has recorded at least one hit in each of his last six home appearances against the Blue Jays.
• Chris Bassitt has recorded a win in four of his last five appearances.
• Pete Alonso ranks T4th in the league in Home Runs (40) this season.

Toronto Blue Jays Player Prop Facts

• Kazuma Okamoto has hit a home run in four of the Blue Jays’ last seven night games against opponents that held a losing record.
• Max Scherzer has recorded six or more strikeouts in six of his last seven road appearances against the Orioles.
• Alejandro Kirk has recorded at least one hit in each of his last 14 appearances with the Blue Jays as underdogs.
• Kazuma Okamoto ranks T10th in the league in Home Runs (33) this season.

Matchup/League Facts

• The Orioles rank 28th in the league for strikeouts against this season (1474).
• The Orioles rank 27th in the league for batting average this season (.234).
• The Blue Jays rank 30th in the league for triples this season (8).
• The Blue Jays rank 29th in the league for runs scored this season (632).

Blue Jays vs Orioles Prediction

The Blue Jays are 4-2 in their last 6 meetings against the Orioles but have lost their last three visits in Baltimore.

In this Blue Jays vs Orioles Prediction, the Orioles are coming as -120 home favorites. I like the Orioles to keep rolling at home as long as they have a mathematical chance for the wild card spot. Bassitt has been solid at home with a 3.53 ERA, while Scherzer has been shaky at best. The Orioles’ bullpen has been in excellent form lately and have been much better against right-handed pitching than the Jays in their last 5 games. Take the Orioles to win this one at home.

Nikos Lagouretos's Pick: Baltimore Orioles ML