Tampa Bay Rays vs Chicago White Sox Prediction 9/10/2025 Today’s MLB Picks

In this article, we will formulate a Rays vs White Sox Prediction for this MLB game on Wednesday, September 10th at the Rate Field in the second game of this series, with the Rays having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 55-90 record this season and are sitting on the last place of the AL Central. The White Sox have a 30-43 home record and are 69-68 in over/under. They are coming off a 4-5 home defeat by the Rays, but are still 7-2 in their last 9 games. Over is 6-2 in their last 8 games and are playing the Guardians and the Orioles next.

The White Sox have a .235 batting average this season, .304 OBP and .378 Slugging percentage. Chicago’s pitching staff has a 4.24 ERA and 1.36 WHIP. Lenyn Sosa leads the White Sox with 123 hits, and he is the team’s best hitter with a .265 batting average. He also leads the team in RBI with 65, adding a team-high 20 home runs.

The White Sox have not yet announced a starting pitcher for this game.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 72-72 record this season and are sitting on the 4th place of the AL East. The Rays have a 34-36 road record and are 62-73 in over/under. They are coming off a 5-4 road victory over the White Sox, that ended their three-game losing streak. Over is 6-3 in their last 9 games and are playing the Cubs and the Blue Jays next.

The Rays have a .252 batting average this season, .313 OBP and .403 slugging percentage. Tampa’s pitching staff has a 3.85 ERA and 1.20 WHIP.  Yandy Diaz leads the Rays with 155 hits, and he is the team’s best hitter with .290 batting average. Junior Caminero leads the team in RBI, with 103 and in home runs, with 41.

Griffin Jax (R) is the projected starting pitcher for the Rays, and he has a 1-7 record, 4.81 ERA and 1.38 WHIP.

Tampa Bay Rays @ the Chicago White Sox Betting Trends: September 10, 2025

• Probable Starting Pitcher: TBD

Why the Chicago White Sox will win

• The Rays have lost eight of their last nine road games against American League opponents following a road win.
• The White Sox have won seven of their last eight games after playing the previous day.
• The White Sox have covered the run line in eight of their last nine games.
• The Rays have failed to cover the run line in seven of their last eight games against AL Central opponents that held a losing record.
• The Rays have trailed after 5 innings in three of their last four games at Rate Field.

• Probable Starting Pitcher: Griffin Jax      Record this season: 1-7      ERA: 4.81
• Road Record: 0-6
• Last 5 against White Sox: 0-0

Why the Tampa Bay Rays will win

• The road team has won seven of the White Sox’s last eight games.
• The White Sox have lost seven of their last eight night games against American League opponents following a loss.
• The White Sox have failed to cover the run line in seven of their last eight night games against American League opponents following a loss.
• The road team has covered the run line in four of the last five games between the Rays and White Sox.
• The Rays have led after 5 innings in each of their last five road games.
• The Rays have led after 3 innings in each of their last five road games.

Total Runs Facts

• Five of the last six games between the Rays and White Sox at Rate Field have gone OVER the total runs line.
• Nine of the Rays’ last 12 night games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last four games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Rays’ last eight night games at Rate Field.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has recorded at least one hit in each of his last eight home appearances.
• Luis Robert has hit at least one home run in six of his last 18 home appearances against AL East opponents.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has recorded at least one hit in each of his last nine Wednesday appearances against teams that held a losing record.
• Josh Lowe has hit a home run in each of the Rays’ last two night games.
• Yandy Diaz has recorded a Double in four of the Rays’ last five road games against AL opponents.

Matchup/League Facts

• The White Sox rank 29th in the league for walks allowed this season (535).
• The White Sox rank 28th in the league for slugging percentage this season (.378).
• The Rays rank 1st in the league for steals this season (178).
• The Rays are one of only two teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Rays vs White Sox Prediction

The White Sox are 6-4 in their last 10 meetings against the Rays, and are 3-1 in their last 4 meetings in Chicago. Over is 3-1 in their last 4 meetings.

The White Sox were one of the hottest teams in baseball prior to yesterday’s loss, and without a starting pitcher announced, I don’t know what to expect from them. The Rays are going for a bullpen game, and were terrible before yesterday’s win, having scored just 4 total runs in their three games before that. Too many uncertainties in this game, and I will personally stay off this one, but as a slight lean, I would side with the White Sox and possibly the plus money at home.