Tampa Bay Rays vs Arizona Diamondbacks Prediction 4/22/25 MLB Picks

In this article, we will formulate a Rays vs Diamondbacks prediction for this MLB game on Tuesday, April 22, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays (9-13, 0-3 Away) snapped a four-game losing skid with a 10-8 extra-inning win over the Yankees, but returned to losing ways with a 4-0 defeat to the Yankees. Tampa Bay lost back-to-back home series against the Red Sox and Yanks, and now will play two series on the road against the Diamondbacks and Padres. Ryan Pepiot took the loss in a recent defeat after allowing three runs on six hits with seven strikeouts and one walk in 6.0 innings.

This year, the Rays average 4.27 runs per game (17th in the MLB) on a .258/.326/.399 triple-slash. When it comes to pitching, the Rays’ staff has a 3.66 ERA (11th) and 1.17 WHIP (8th). Jonathan Aranda leads the Rays with a .355 batting average, four home runs, and 13 RBI this season.

Zack Littell will take the mound for the Rays on Tuesday. The 29-year-old right-hander has a 0-4 record in four starts this year with a 5.48 ERA and 1.26 WHIP in 23.0 innings.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (13-9, 6-4 Home) won three straight series against the Orioles, Brewers, and Marlins, but lost to the Cubs. Arizona was on a five-game winning streak and swept the Marlins in the process, but then lost back-to-back games to the Cubs. The D-backs salvaged the series from being swept with a 3-2 extra-innings victory in Game 3. Josh Naylor led the offense with two RBI, while Merrill Kelly pitched for 5.2 innings in a no-decision, allowing one run on two hits with five strikeouts and one walk. Shelby Miller was credited with the win.

This season, the Diamondbacks average 5.45 runs per game (3rd in the MLB) on a .251/.340/.442 slash line. Regarding pitching, the Diamondbacks’ staff has a 4.43 ERA (24th) and 1.22 WHIP (11th). Corbin Carroll leads the Diamondbacks with a .323 batting average, seven home runs, and 19 RBI this season.

The projected starting pitcher for the Diamondbacks is Brandon Pfaadt, who is 3-1 in four starts this season, with a 3.04 ERA and 1.10 WHIP in 23.2 innings.

Total Runs Facts

• Each of the Rays’ last four night games against NL West opponents have gone OVER the total runs line.
• Six of the Diamondbacks’ last seven home games following an extra innings win have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Diamondbacks’ last eight night games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rays’ last four night games against NL West opponents.

Matchup/League Facts

• The Diamondbacks rank 3rd in the league for slugging percentage this season (.442).
• The Diamondbacks rank 3rd in the league for walks this season (96).
• The Rays rank 3rd in the league for walks allowed this season (58).
• The Rays rank 5th in the league for batting average this season (.258).

Rays vs Diamondbacks Prediction

The Rays won eight of the previous ten H2H encounters, including the last five. Six of those ten H2Hs went Over, and I am going with another Over here because of the pitching matchup. I don’t trust Littell, who has been the weakest Rays’ starter this season, and although he was solid in his latest start against Boston, facing the D-backs’ offense, which is the third-best in MLB, will be much more challenging for Littell. Pfaadt allowed just one run in his last two starts, and I don’t think he can maintain that level of quality any longer. I am leaning toward Arizona, but will opt for Over instead.