Baltimore Orioles vs Washington Nationals Prediction 4/22/25 MLB Picks

Washington Nationals (9-13) vs Baltimore Orioles (9-12)

Game Info: Tuesday, April 22, 2025 at 6:45 pm (Nationals Park)

D. KREMER (R) vs M. Parker (L)

Betting Odds: Washington Nationals +114 / Baltimore Orioles -135 --- Over/Under: 9 Click Here for the Latest Odds

Where to Watch: MLB.TV

The Baltimore Orioles and the Washington Nationals meet Tuesday in MLB action from Nationals Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Washington Nationals prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Dean Kremer for the start here, and Kremer is 2-2 with a 6.41 ERA and 13 strikeouts this season. In his career, Kremer is 3-0 with a 2.04 ERA and 10 strikeouts against the Nationals. The Washington Nationals will start Mitchell Parker here, and Parker is 2-1 with a 1.85 ERA and 16 strikeouts this season. This will be Parker’s second career start against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to bounce back from a humiliating 24-2 loss in their series rubber match against Cincinnati last time out to fall to 9-12 on the year. After this series, the Orioles will head on the road once again to take on the Detroit Tigers.

Orioles Drop Series Vs. Reds

Cedric Mullins has a team-high 19 hits so far this season as well as team-highs of 5 doubles, 6 home runs, and 19 RBIs with 3 stolen bases and a .284 batting average, while Adley Rutschman has 16 hits with a pair of doubles, 4 homers, and 7 RBIs. Ryan Mountcastle has 16 hits with 4 doubles, and Tyler O’Neill has 14 hits with 3 doubles, a triple, and 2 homers with 9 RBIs. Jordan Westburg added 4 home runs, and Gunnar Henderson has a team-high 20 strikeouts as well this season.

Why the Baltimore Orioles will win

  • The Nationals have lost 16 of their last 17 night games following a road loss.
  • The Orioles have won each of their last four games at Nationals Park against NL East opponents that held a losing record.
  • The Nationals have failed to cover the run line in each of their last five games against American League opponents.
  • The Orioles have covered the run line in each of their last four games against NL East opponents.

Baltimore Orioles Player Prop Facts

  • Dean Kremer has recorded a win in four of his five previous road appearances against NL East opponents.
  • Tyler O'Neill has recorded at least one Single in each of his last nine appearances against NL East opponents.
  • Dean Kremer has recorded six or more strikeouts in three of his last four appearances with the Orioles as road favorites against NL opponents.
  • Tyler O'Neill has scored at least one run in each of his last five appearances with his team as a favorite against NL East opponents.
  • Ramon Laureano has recorded at least one hit in each of his last 15 appearances in night games against teams that held a losing record.
  • Colton Cowser has recorded at least one RBI in each of the Orioles' last four games as road favorites against NL East opponents.
  • Ryan O'Hearn has hit a home run in each of his last two appearances in night games.
  • Cedric Mullins ranks 5th amongst qualified players for On Base Percentage (.429) this season.

Washington Nationals Recap

The Washington Nationals come into this game looking to bounce back from their 3-1 loss in the second half of Sunday’s double-header against the Colorado Rockies to fall to 9-13 this season. After this series, the Nationals will have a division series against the New York Mets at home.

Nationals Win Series Vs. Rockies After Double-Header Split

Keibert Ruiz has 22 hits with a pair of doubles and a pair of home runs with 11 RBIs, while James Wood has 19 hits with 3 doubles and a team-high 7 home runs along with 17 RBIs. Nathaniel Lowe has 23 hits with a team-high 5 doubles and 17 RBIs, along with 3 home runs and a team-high 26 strikeouts. CJ Abrams has 4 home runs and 7 RBIs along with 4 stolen bases, while Paul DeJong has 4 doubles of his own and 24 strikeouts as well this season. Dylan Crews has also logged a team-high 6 stolen bases this season.

Why the Washington Nationals will win

  • The Orioles have lost each of their last seven night games against teams that held a losing record.
  • The Nationals have won four of their last five games as home underdogs.
  • The Orioles have failed to cover the run line in each of their last 17 Tuesday games as favorites against National League opponents.
  • The Nationals have covered the run line in each of their last five games at Nationals Park.

Washington Nationals Player Prop Facts

  • Jacob Young has recorded at least one Double in three of the Nationals' last four night games against AL opponents that held a losing record.
  • Josh Bell has hit a home run in three of his last four appearances against the Orioles.
  • Jacob Young has scored at least one run in each of his last six home appearances against AL opponents that held a losing record.
  • Josh Bell has recorded at least one RBI in six of his seven previous home appearances against AL East opponents that held a losing record.
  • Josh Bell has recorded at least one Single in each of his last seven appearances with his team as an underdog against the Orioles.
  • Nathaniel Lowe has recorded at least one hit in each of his last 11 home appearances after not playing the previous day.
  • James Wood ranks T5th in the league in Home Runs (7) this season.

Total Runs Facts

  • Each of the Nationals' last eight night games against American League opponents have gone UNDER the total runs line.
  • Seven of the Orioles' last eight games have gone OVER the total runs line.

Baltimore Orioles vs. Washington Nationals Prediction

I’m on the Nationals here. I get the case to be made for the Orioles, as this is still a loaded lineup. However, while I normally don’t back teams off of a Coors Field series, the Nationals had a day off to reacclimate, and I like what Mitchell Parker’s brought to the table so far this season. I haven’t been a fan of Dean Kremer so far this year, and I think that the Nationals get to him and get the win here. Give me Washington.

Chris’s Pick Washington Nationals +114

Get Premium Picks Start Winning Now »
The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

18+ Has gambling become a problem for you? Call the National Problem Gambling Hotline.
1-800-522-4700 | ncpgambling.org

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.

Dismiss