Philadelphia Phillies vs New York Mets Prediction 4/22/25 MLB Picks

Phillies Drop Back-To-Back Games

Nick Castellanos has a team-high 24 hits with 6 doubles, including 3 home runs and 14 RBIs, while Kyle Schwarber has 22 hits with a team-high 7 home runs and 16 RBIs as well on the year. Bryce Harper has 5 stolen bases, 5 home runs, and 14 RBIs. Trea Turner also has 21 hits with a team-high 6 stolen bases. Max Kepler has 6 doubles and Bryson Stott has 4 doubles, 2 homers, and 13 RBIs, while Stott and J.T. Realmuto also have 4 stolen bases apiece this season.

Why the Philadelphia Phillies will win

• The favorites have won each of the Mets' last six games.
• The Mets have lost nine of their last 10 Tuesday games against NL East opponents that held a winning record.
• The Mets have failed to cover the run line in six of their last seven night games against National League opponents following a win.
• The Phillies have covered the run line in five of their last six games as favorites against National League opponents following a loss.

Philadelphia Phillies Player Prop Facts

• Max Kepler has recorded a Double in each of his last three appearances in night games against NL teams that held a winning record.
• Bryce Harper has hit a home run in three of the Phillies' last four night games.
• Bryce Harper has recorded at least one RBI in five of the Phillies' last six games as favorites against NL opponents.
• Max Kepler has scored at least one run in each of his last nine appearances with his team as a road favorite against NL East opponents.
• Bryson Stott has recorded a Single in each of his last seven appearances against opponents that held a winning record.
• Bryce Harper has recorded at least one hit in each of his last 10 appearances with the Phillies as favorites against NL East opponents.
• Kyle Schwarber ranks T5th in the league in Home Runs (7) this season.

New York Mets Recap

The New York Mets come into this game looking to add on to their series-opening win over the Phillies from Monday’s matchup to improve to 16-7 on the year. After this series, the Mets will head on the road for a series against the Washington Nationals.

Mets Win 5th In A Row

Pete Alonso has a team-high 28 hits with 9 doubles, 6 home runs, 24 RBIs, and a .341 batting average, while Juan Soto has 20 hits with 5 doubles, 3 home runs, and 12 RBIs on the year. Francisco Lindor has 25 hits with a pair of stolen bases along with 4 doubles, 5 home runs, and 13 RBIs, while Brandon Nimmo has a team-high 19 strikeouts so far this season. Nimmo has also added 18 hits with 3 doubles and 4 home runs, and 10 RBIs this season. Luis Torrens has also chipped in 6 doubles, and Luisangel Acuna has 6 stolen bases as well this season.

Why the New York Mets will win

• The home team has won each of the Mets' last seven games.
• The Phillies have lost 10 of their last 11 games at Citi Field against NL East opponents that held a winning record.
• The Mets have covered the run line in eight of their last nine games as underdogs after playing the previous day.
• The Phillies have failed to cover the run line in seven of their last eight games as favorites against the Mets following a road loss.

New York Mets Player Prop Facts

• Francisco Lindor has hit at least one home run in three of the Mets' last four games against NL opponents.
• Griffin Canning has recorded a win in three of his last four home appearances against NL opponents.
• Francisco Lindor has recorded at least one RBI in five of his last six appearances in night games against NL East teams that held a winning record.
• Griffin Canning has recorded six or more strikeouts in four of his last five home appearances against NL opponents.
• Francisco Lindor has recorded at least one hit in each of his last 10 home appearances against NL East opponents.
• Nick Madrigal has recorded at least one Single in each of his eight previous Tuesday appearances against NL teams that held a winning record.
• Jose Siri has scored a run in seven of his last eight appearances in night games.
• Pete Alonso ranks 2nd amongst qualified players for Slugging Percentage (.695) this season.

Total Runs Facts

• Each of the Mets' last nine games as underdogs against National League opponents have gone OVER the total runs line.
• Each of the Phillies' last eight games have gone OVER the total runs line.

Philadelphia Phillies vs. New York Mets Prediction

I’m on the Phillies here. I think that if there’s a spot for the Phillies to get one in this set, it’s here, as the Phillies had some late momentum with a rally before falling short in Monday’s matchup. Canning is still a pitcher I’m not 100% sold on in this Mets’ rotation, and Sanchez is cementing himself as one of the better lefty starters in baseball this season. I think the Phillies can get it done to even up the series. Give me the Phillies.