Los Angeles Dodgers vs Chicago Cubs Prediction 4/22/25 MLB Picks

Chicago Cubs (14-10) vs Los Angeles Dodgers (16-7)

Game Info: Tuesday, April 22, 2025 at 7:40 pm (Wrigley Field)

D. MAY (R) vs S. Imanaga (L)

Betting Odds: Chicago Cubs +102 / Los Angeles Dodgers -122 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Dodgers vs Cubs prediction for this MLB game on Tuesday, April 22, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers (16-7, 6-5 Away) lost three straight series to the Phillies, Nationals, and Cubs, but responded with a series sweep of the Rockies and defeated the Rangers. Los Angeles won two of three games in that series, and both wins were without allowing a single run. The Dodgers' latest 1-0 victory came thanks to Freddie Freeman's sac fly in the 8th inning, while Tyler Glasnow pitched for 4.0 innings in a no-decision, allowing no runs on three hits with six strikeouts and one walk. Ben Casparius was credited with the win.

This season, the Dodgers average 4.35 runs per game (15th in the MLB) on a .227/.311/.415 slash line. Regarding pitching, the Dodgers’ staff has a 3.55 ERA (7th) and 1.23 WHIP (15th). Teoscar Hernandez leads the Dodgers with a .250 batting average, five home runs, and 17 RBI this season.

The projected starting pitcher for the Dodgers is Dustin May, who is 1-1 in three starts this season, with a 1.06 ERA and 0.76 WHIP in 17.0 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (14-10, 6-5 Home) came back home from California and a series against the Dodgers and Padres. After beating the Dodgers, the Cubs lost to the Padres and then defeated the Diamondbacks at home. They were close to getting a sweep of Arizona, but the D-backs were better in Game 3, winning 3-2 in extra innings. Jameson Taillon pitched for 5.0 innings in a no-decision, allowing one run on three hits with six strikeouts and two walks. Jordan Wicks took the loss.

This year, the Cubs average 6.04 runs per game (1st in the MLB) on a .258/.338/.447 triple-slash. When it comes to pitching, the Cubs’ staff has a 4.16 ERA (18th) and 1.36 WHIP (25th). Kyle Tucker leads the Cubs with a .302 batting average, six home runs, and 23 RBI this season.

Shota Imanaga will take the mound for the Cubs on Tuesday. The 31-year-old right-hander has a 2-1 record in five starts this year with a 2.22 ERA and 0.99 WHIP in 28.1 innings.

Total Runs Facts

  • Each of the Cubs' last four games following an extra innings loss have gone UNDER the total runs line.
  • Six of the Dodgers' last seven games have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Cubs' last seven games as underdogs against NL West opponents.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Dodgers' last five games against NL Central opponents.

Matchup/League Facts

  • The Cubs rank 1st in the league for triples this season (7).
  • The Cubs rank 1st in the league for RBIs this season (142).
  • The Dodgers rank 27th in the league for walks allowed this season (88).
  • The Dodgers rank 25th in the league for steals this season (11).

Dodgers vs Cubs Prediction

The teams have traded victories over the past few years, as each recorded five in the previous ten H2H encounters. They have already met on five occasions this season, and the Dodgers lead the series 3-2. Dustin May has been very strong in his three starts this year, while Shota Imanaga has already shut the Dodgers out over 4.0 innings this year. Imanaga allowed a .176 BA in 51 at-bats against the Dodgers in his career. I expect a low-scoring affair, and I am going with Under.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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