Padres vs Tigers Prediction 4/22/25 MLB Picks

Detroit Tigers Betting Preview

The Detroit Tigers are 14-9 this season after they won game one by a score of 6-4 on Monday. Detroit took a 2-1 lead in the first inning, and they scored four straight runs in the second and third, before hanging on for the win in the later innings. The Tigers recorded 11 hits in the game, and they were led by Torres, who went 3-5 with two RBIs in the win. Detroit started Montero, who allowed five hits and three earned runs, while Hanifee got the win and Vest got the save. 

Prior to this series, the Tigers won three out of four against the Royals, but did lose two out of three against the Brewers before that. Detroit has won four of its last five games, and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.11 ERA with a 1.15 WHIP and a .216 opponent batting average, while the offense has scored 106 runs with a .250 batting average and a .329 on-base percentage this season. Spencer Torkelson has led Detroit with seven home runs and 21 RBIs, while Kerry Carpenter has added five home runs and 11 RBIs this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 1-1 with a 2.53 ERA and a 1.08 WHIP over 21.1 innings pitched this season. 

Why the Tigers will beat the Padres 

• The Tigers have won five of their last six home games against National League opponents.
• The Padres have lost four of their last five road games against teams that held a winning record.
• The Tigers have covered the run line each of their last seven games at Comerica Park against teams that held a winning record.
• The Padres have failed to cover the run line in four of their last five games at Comerica Park.
• The Padres have trailed after 5 innings in each of their last five road games against opponents that held a winning record.
• The Padres have trailed after 3 innings in each of their last three road games against opponents that held a winning record.
• The Padres have lost the first inning in each of their last three night games against AL Central opponents that held a winning record.

Why the Padres will beat the Tigers 

• The Padres have won each of their last five games as road underdogs against American League opponents following a loss.
• The Tigers have lost six of their last eight games as home favorites against National League opponents following a home win.
• The Padres have covered the run line in each of their last five games as underdogs against American League opponents following a road loss.
• The Tigers have failed to cover the run line in six of their last eight home games against National League opponents following a home win.

Total Runs Facts

• Each of the Tigers' last four games against NL West opponents have gone OVER the total runs line.
• Four of the Padres' last five road games against AL Central opponents have gone UNDER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in eight of the Tigers' last nine home games against NL West opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in four of the Padres' last five games as road underdogs against AL Central opponents.

Detroit Tigers Player Prop Facts

• Javier Baez has hit a home run in four of his last seven appearances with his team as a favorite against the Padres.
• Jack Flaherty has recorded a win in three of his last four appearances at Comerica Park.
• Javier Baez has scored at least one run in each of his last seven appearances with his team as a home favorite against the Padres.
• Jack Flaherty has recorded six or more strikeouts in each of his last three home appearances against opponents that held a winning record.
• Javier Baez has recorded a Single in each of his last seven home appearances after playing the previous day.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Manuel Margot has recorded an RBI in each of his last four appearances against NL West opponents.
• Matt Vierling has recorded a Double in three of his last four appearances at Comerica Park against NL opponents that held a winning record.
• Spencer Torkelson ranks 8th amongst qualified players for Slugging Percentage (.619) this season.

San Diego Padres Player Prop Facts

• Nick Pivetta has recorded a win in three of his last four appearances against AL Central opponents that held a winning record.
• Fernando Tatis Jr. has recorded an RBI in seven of his last eight appearances against AL Central opponents that held a winning record.
• Fernando Tatis Jr. has scored at least one run in each of his last six appearances with the Padres as underdogs against AL opponents.
• Fernando Tatis Jr. has recorded at least one Single in each of his last six road appearances against AL Central opponents that held a winning record.
• Luis Arraez has recorded at least one hit in each of his last 15 road appearances against AL Central opponents.
• Connor Joe has recorded a Double in each of his three previous appearances against the Tigers after playing the previous day.
• Martin Maldonado has hit a home run in three of his last four appearances against AL opponents that held a winning record.
• Fernando Tatis Jr. ranks T3rd in the league in Home Runs (8) this season.

Matchup/League Facts

• The Tigers rank 3rd in the league for ERA this season (3.11).
• The Tigers rank 4th in the league for runs allowed this season (80).
• The Padres rank 1st in the league for strikeouts against this season (148).
• The Padres rank 2nd in the league for ERA this season (2.90).

Padres vs Tigers Prediction 

Detroit continues to play great baseball at home so far this year, where they are 9-2 on the season. The Tigers have won four of their last five games, and they are starting Flaherty, who has allowed two earned runs or fewer in three of his first four starts. San Diego started the season as the best team in the MLB, but they have lost three of their last four games, and they are just 4-6 on the road. The Padres will start Pivetta, who has allowed one earned run or fewer in three of his first four starts. I really like how both pitchers have looked this season, and I think we will see a very low-scoring game, so take the under here.