Toronto Blue Jays vs Houston Astros Prediction 4/22/25 MLB Picks

Houston Astros Betting Preview

The Houston Astros are 11-11 on the year and play the Royals, Tigers, and White Sox next. The Houston Astros are batting .226 on the season, have a .304 OBP, and a .336 slugging percentage. The Houston Astros' pitching staff has a 3.46 ERA and a 1.12 WHIP. Jose Altuve leads the Houston Astros with 27 hits and 9 RBI, while Isaac Paredes and Jake Meyers have combined for 37 hits and 17 RBI.

Ronel Blanco gets the ball for the Houston Astros, and he is 1-2 with a 6.48 ERA and 17 strikeouts this season. Blanco is 1-0 with a 1.69 ERA and 16 strikeouts in his career against the Toronto Blue Jays.

Why the Houston Astros will win

• The Astros have won five of their last six games against the Blue Jays.
• The Blue Jays have lost each of their last three games.
• The Astros have covered the run line in seven of their last eight games against the Blue Jays.
• The Blue Jays have failed to cover the run line in four of their last five night games against AL West opponents.
• The Blue Jays have trailed after 5 innings in six of their last seven night games at Daikin Park against American League opponents.

Why the Toronto Blue Jays will win

• The Astros have lost each of their last six games as home favorites following a win.
• The Blue Jays have won each of their last four games as road underdogs against the Astros following a road loss.
• The Blue Jays have covered the run line in each of their last eight games as underdogs following a road loss.
• The Astros have failed to cover the run line in each of their last seven night games against the Blue Jays at Daikin Park following a home win.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in three of the Astros' last four home games against AL opponents.
• Isaac Paredes has recorded at least one RBI in each of his last five home appearances against AL opponents that held a winning record.
• Jose Altuve has scored at least one run in each of his last seven appearances against the Blue Jays.
• Jeremy Pena has recorded a Single in each of the Astros' last six games against AL opponents.
• Jeremy Pena has recorded at least one hit in each of the Astros' last 12 games.

Toronto Blue Jays Player Prop Facts

• Bo Bichette has recorded an RBI in four of the Blue Jays' last five games as underdogs against AL opponents.
• Chris Bassitt has recorded seven or more strikeouts in three of his last four appearances.
• Bo Bichette has recorded at least one Single in each of the Blue Jays' last six games as underdogs against AL opponents.
• Andres Gimenez has recorded at least one hit in eight of his last nine appearances with his team as a road underdog against AL West opponents.
• Daulton Varsho has hit a home run in two of his last three appearances with the Blue Jays as underdogs against AL West opponents.
• Myles Straw has scored at least one run in three of his last four appearances in night games.
• Bo Bichette ranks 4th in the league in Hits (31) this season.

Toronto Blue Jays vs Houston Astros Prediction

The Blue Jays aren’t having the best week in terms of results, but the offense continues to show up, and that makes them a team to watch. The wins will come eventually if the bats keep producing. Bassitt has been ridiculous through 23.1 innings, allowing 20 hits and two runs while striking out 31. In his last 17.1 innings, Bassitt has allowed 12 hits and one run. Combine that with the Blue Jays' offense, and this should be a victory. Blanco was great last year, but he’s allowed 18 hits and 12 runs through 16.2 innings. Blanco has a 6.94 ERA through 11.2 innings in the month of April. No, thank you. The Astros have also had issues stringing wins together this season. I’ll gladly lay the cheap price with the Blue Jays on Tuesday.