New York Yankees vs Cleveland Guardians Prediction 4/22/25 MLB Picks

Cleveland Guardians Betting Preview

The Cleveland Guardians are 13-9 on the year and play the Red Sox, Twins, and Blue Jays next. The Cleveland Guardians are batting .240 on the season, have a .313 OBP, and a .402 slugging percentage. The Cleveland Guardians' pitching staff has a 3.98 ERA and a 1.35 WHIP. Steven Kwan leads the Cleveland Guardians with 29 hits and 14 RBI, while Jose Ramirez and Carlos Santana have combined for 40 hits and 19 RBI.

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 1-2 with a 5.85 ERA and 15 strikeouts this season. This will be Bibee’s second career game against the New York Yankees.

Why the Cleveland Guardians will win

• The Guardians have won each of their last three games as underdogs after playing the previous day.
• The Yankees have lost four of their last five night games against teams that held a winning record.
• The Yankees have failed to cover the run line each of their last four games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last four games after playing the previous day.
• The Guardians have led after 3 innings in each of their last three games.
• The Yankees have trailed after 5 innings in four of their last five games against American League opponents that held a winning record.

Why the New York Yankees will win

• The Guardians have lost 11 of their last 12 night games against the Yankees following a home win.
• The Yankees have won eight of their last nine games at Progressive Field following a loss.
• The Yankees have covered the run line in each of their last eight Tuesday games as road favorites against AL Central opponents.
• The Guardians have failed to cover the run line in 10 of their last 11 games against the Yankees following a home win.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians' last four Tuesday night games against AL East opponents that held a winning record.
• Jose Ramirez has recorded at least one RBI in each of the Guardians' last five Tuesday night games against AL East opponents that held a winning record.
• Steven Kwan has scored at least one run in each of the Guardians' last four night games against opponents that held a winning record.
• Steven Kwan has recorded at least one Single in each of his last eight appearances with the Guardians as home underdogs against AL opponents.
• Steven Kwan has recorded at least one hit in each of the Guardians' last 11 games as home underdogs against the Yankees.
• Steven Kwan ranks T8th in the league in Hits (29) this season.

New York Yankees Player Prop Facts

• Paul Goldschmidt has recorded at least one Single in each of the Yankees' last eight games as road favorites.
• Aaron Judge has scored at least one run in 15 of the Yankees' last 16 Tuesday night games against AL Central opponents that held a winning record.
• Paul Goldschmidt has recorded at least one hit in each of his last 11 road appearances against opponents that held a winning record.
• Giancarlo Stanton has hit a home run in five of his last six appearances against the Guardians.
• Giancarlo Stanton has recorded at least one RBI in each of his last nine road appearances against AL Central opponents that held a winning record.
• Aaron Judge ranks 1st amongst qualified players for Batting Average (.384) this season.

New York Yankees vs Cleveland Guardians Prediction

Warren isn’t a pitcher I’m excited to get behind as he’s been a disaster through nine career starts. In 38.1 innings, Warren has an 8.22 ERA and 1.70 WHIP. Bibee is the more trustworthy pitcher overall, but he’s struggled this year with a 5.85 ERA and 1.50 WHIP through 20 innings. The difference is that the Yankees have a more consistent lineup to back up potential struggles. Also, the Yankees have bounced back nicely this season after losses. If forced to pick a side between two struggling pitchers, I want the better offense. Give me the Yankees and the reasonable price.