St. Louis Cardinals vs Washington Nationals Prediction 4/7/2026 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Nationals Prediction for this MLB matchup on Tuesday, April 7th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Preview

The Washington Nationals have a 4-6 record this season and are sitting in the fifth place of the NL East. They have a 1-3 home record and are coming off a 9-6 home win against the Cardinals. They dropped their previous three home games to the Dodgers by scores of 6-8, 5-10, and 6-13.

The Nationals have a .277 batting average this season, .352 OBP and .457 Slugging percentage. Washington’s pitching staff has a 6.24 ERA and 1.63 WHIP. Brady House is the team’s best hitter with a .333 batting average. CJ Abrams leads the team in RBI with 13, also adding a team-high 4 home runs.

Cade Cavalli (R) is the projected starting pitcher for the Nationals, and he has a 0-0 record, 2.79 ERA and 1.34 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 5-5 record this season and are sitting in the fourth place of the NL Central. They have a 1-3 road record and are coming off a 6-9 road loss against the Nationals. Their previous three games were a 5-3 win, a 6-11 loss, and a 0-4 loss on the road against against the Tigers.

The Cardinals have a .222 batting average this season, .305 OBP and .353 Slugging percentage. St. Louis’ pitching staff has a 5.40 ERA and 1.63 WHIP. Jordan Walker is the team’s best hitter with a .314 batting average, also leading the team in RBI with 9 and adding a team-high 3 home runs.

Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 0-0 record, 1.64 ERA and 1.18 WHIP.

St. Louis Cardinals @ Washington Nationals Betting Trends: April 7, 2026

• Probable Starting Pitcher: Cade Cavalli      Record this season: 0-0      ERA: 2.79
• Home Record: 0-0
• Last 5 against Cardinals: –

Why the Washington Nationals will win

• The Cardinals have lost seven of their last eight road games.
• The home team has won five of the Cardinals’ last six games.
• The Cardinals have failed to cover the run line in seven of their last eight road games.
• The Nationals have covered the run line in each of their last four night games against National League opponents.
• The Cardinals have trailed after 3 innings in five of their last six games against NL East opponents that held a losing record.
• The Cardinals have trailed after 5 innings in each of their last six road games against National League opponents.
• The Cardinals have lost the first inning in three of their last four road games against National League opponents.

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 0-0      ERA: 1.64
• Road Record: 0-0
• Last 5 against Nationals: 0-0

Why the St. Louis Cardinals will win

• The Nationals have lost four of their last five games as home favorites following a win.
• The Cardinals have won each of their last three games as road underdogs against NL East opponents following a loss.
• The Nationals have failed to cover the run line in 10 of their last 11 home games.
• The road team has covered the run line in seven of the Nationals’ last eight games.
• The Cardinals have led after 5 innings in five of their last six games at Nationals Park.
• The Cardinals have led after 3 innings in four of their last five games at Nationals Park.

Total Runs Facts

• Seven of the Nationals’ last eight home games have gone OVER the total runs line.
• Each of the Cardinals’ last four games as underdogs against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last four games as favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Cardinals’ last five games as underdogs.

Washington Nationals Player Prop Facts

• CJ Abrams has hit a home run in four of the Nationals’ last five games.
• CJ Abrams has recorded at least one hit in each of the Nationals’ last seven games.
• Nasim Nunez ranks 1st in the league in Steals (5) this season.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has recorded at least one hit in each of his last nine road appearances against NL East opponents.
• Ramon Urias has hit a home run in each of his last two appearances against NL opponents.

Matchup/League Facts

• The Nationals rank 30th in the league for ERA this season (6.27).
• The Nationals rank 30th in the league for opponent batting average this season (.283).
• The Cardinals rank 30th in the league for strikeouts this season (55).
• The Cardinals rank 28th in the league for hits allowed this season (87).

Cardinals vs Nationals Prediction

The Cardinals are 6-2 in their last 8 meetings against the Nationals and are 3-1 in their last 4 visits in Washington.

In this Cardinals vs Nationals Prediction, both teams are coming at a pickem price. The Nationals snapped their five-game losing streak yesterday but they were involved in yet another high scoring game, as they are 5-0 to the over in their last 5 games. Both starting pitchers are coming off quality starts but both had 4+ ERA last season and both bullpens are bottom-6 in the league. Both teams also average 11 runs per game combined, so with the total set at just 7.5, I will go over that number.

Nikos Lagouretos's Pick: Over 7.5