St. Louis Cardinals vs San Diego Padres Prediction 08/02/2025 Today’s MLB Picks

In this article, we will formulate a Saint Louis Cardinals vs San Diego Padres Prediction for this MLB game on Saturday, August 2^nd at the Petco Park in the second game of this series, with the Padres having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 61-49 record this season and are sitting on the second place of the NL West. They have a 35-18 home record, and are 44-63 in over/under. The Padres are coming off a 4-1 home victory over the Cardinals, and have six consecutive wins. Under is 8-3 in their last 11 games and are playing the Red Sox and the Diamondbacks next. 

The Padres have a .250 batting average this season, .318 OBP and .378 Slugging percentage. San Diego’s pitching staff has a 3.52 ERA and 1.21 WHIP.  Manny Machado leads the Padres with 128 hits, adding team-high .302 batting average and a team-high 71 RBI. He also adds a team-high 20 home runs. 

Randy Vasquez (R) will take the mound for the Padres, and he has a 3-4 record, 3.65 ERA and 1.37 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 55-56 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 23-32 road record and are 55-50 in over/under They are coming off a 1-4 road defeat by the Padres, and are 1-5 in their last 6 games. Under is 5-1-1 in their last 7 games and are playing the Dodgers and the Cubs next.

The Cardinals have a .249 batting average this season, .319 OBP and .388 Slugging percentage. Saint Louis’ pitching staff has a 4.15 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 111 hits, while Alec Burleson is the team’s best hitter with a .284 batting average. Wilson Contreras leads the team in RBI, with 62, adding a team-high 15 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 2-2 record, 4.91 ERA and 1.21 WHIP.

Why the San Diego Padres will win

• The Padres have won each of their last six games.
• The Cardinals have lost eight of their last nine games at Petco Park against NL West opponents that held a winning record.
• The Padres have covered the run line in seven of their last eight games at Petco Park.
• The Cardinals have failed to cover the run line in seven of their last eight road games.
• The Cardinals have trailed after 3 innings in seven of their last eight road games.
• The Cardinals have trailed after 5 innings in each of their last eight games at Petco Park against National League opponents that held a winning record.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last three games as road underdogs against the Padres following a road loss.
• The Padres have lost 10 of their last 15 games as favorites following a win.
• The Cardinals have covered the run line in each of their last six night games following a road loss.
• The Padres have failed to cover the run line in 13 of their last 15 games as favorites following a win.
• The Padres have trailed after 3 innings in four of their last five games as favorites against NL Central opponents.
• The Padres have trailed after 5 innings in four of their last five games as favorites against NL Central opponents.

Total Runs Facts

• Six of the Cardinals’ last seven games as underdogs against NL West opponents have gone UNDER the total runs line.
• Five of the Padres’ last six home games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Padres’ last nine games as home favorites against National League opponents.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.226).
• The Padres rank 1st in the league for hits allowed this season (816).
• The Cardinals rank 30th in the league for triples this season (4).
• The Cardinals rank 29th in the league for strikeouts this season (804).

Saint Louis Cardinals vs San Diego Padres Prediction

The Padres have won their last three meetings against the Cardinals and under is 5-2 in their last 7 meetings.

In this Saint Louis Cardinals vs San Diego Padres Prediction, the Padres are coming as -140 home favorites. The Padres are rightfully favored, as they have a better overall record, and they have been one of the best home teams in the whole league. The Padres have been red-hot lately, having won six straight, and Vasquez has been better at home with a 3.21 ERA, and he has been in excellent form lately, having a won his last five starts, and has back-to-back games with just one earned run. The Padres also have the best bullpen in the league and are also better against righties. Keep it simple, and take the San Diego Padres to get the job done at home in this one.