St. Louis Cardinals vs Milwaukee Brewers Prediction 9/26/2026 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Saturday, September 26th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 101-59 record this season and are sitting in the 1st place of the NL Central. They have a 53-26 home record and are coming off an 8-4 home win against the Cardinals.

The Milwaukee Brewers have a .258 batting average this season, .340 OBP and .402 Slugging percentage. Milwaukee’s pitching staff has a 3.52 ERA and 1.18 WHIP. Jackson Chourio is the team’s best hitter with a .286 batting average. Brice Turang leads the team in RBI with 97, while Jake Bauers adds a team-high 26 home runs.

Dustin May (R) is the projected starting pitcher for the Brewers, and he has a 7-9 record, 4.67 ERA and 1.32 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 77-83 record this season and are sitting in the 4th place of the NL Central. They have a 39-40 away record and are coming off a 4-8 road loss against the Brewers.

The St. Louis Cardinals have a .241 batting average this season, .314 OBP and .380 Slugging percentage. St. Louis’s pitching staff has a 4.26 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .280 batting average, adding a team-high 115 RBI. Jordan Walker adds a team-high 29 home runs.

Quinn Mathews (L) is the projected starting pitcher for the Cardinals, and he has a 2-3 record, 3.65 ERA and 1.38 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 26, 2026

• Probable Starting Pitcher: Dustin May      Record this season: 7-9      ERA: 4.67
• Home Record: 5-5
• Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine night games after playing the previous day.
• The Cardinals have lost seven of their last eight games at American Family Field.
• The Cardinals have failed to cover the run line in seven of their last eight night games against NL opponents.
• The Brewers have covered the run line in each of their last five games after playing the previous day.
• The Brewers have won the first inning in seven of their last eight home games against opponents that held a losing record.
• The Brewers have led after 3 innings in each of their last six night games against NL Central opponents.
• The Brewers have led after 5 innings in each of their last six home games against NL Central opponents that held a losing record.

• Probable Starting Pitcher: Quinn Mathews      Record this season: 2-3      ERA: 3.65
• Road Record: 0-3
• Last 5 against Brewers: –

Why the St. Louis Cardinals will win

• The Cardinals have won four of their last five road games against NL Central opponents following a loss.
• The Brewers have lost four of their last five Saturday games as favorites against NL Central opponents.
• The Brewers have failed to cover the run line in eight of their last nine games as favorites against the Cardinals following a home win.
• The Cardinals have covered the run line in 11 of their last 13 games as underdogs after playing the previous day.
• The Cardinals have led after 5 innings in each of their last five Saturday games against the Brewers.

Total Runs Facts

• Five of the Brewers’ last six night games against NL Central opponents have gone OVER the total runs line.
• Four of the Cardinals’ last five games have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Brewers’ last 11 night games at American Family Field.
• There has been at least one run scored in the first inning in each of Quinn Mathews’ last four road appearances as a starter.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in three of his last four home appearances.
• Dustin May has recorded four or more strikeouts in each of his last 11 Saturday appearances.
• Joey Ortiz has recorded at least one hit in each of his last 11 appearances against NL opponents.

St. Louis Cardinals Player Prop Facts

• Jordan Walker has hit a home run in three of the Cardinals’ last four games as underdogs against the Brewers.
• JJ Wetherholt has recorded two or more hits in four of his last five road appearances after playing the previous day.
• Alec Burleson ranks T9th in the league in Hits (168) this season.

Matchup/League Facts

• The Brewers rank 1st in the league for hits this season (1404).
• The Brewers rank 1st in the league for batting average this season (.258).
• The Cardinals rank 3rd in the league for home runs allowed this season (156).
• The Cardinals rank T27th in the league for triples this season (14).

Cardinals vs Brewers Prediction

The Brewers are 9-1 in their last 10 meetings against the Cardinals and have won their last four meetings in Milwaukee.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -190 home favorites. The Brewers keep rolling despite having their playoff position locked and I trust them to keep doing so again today. Dustin May has a 3.87 home ERA while Quinn Mathews a 4.68 road ERA and the Brewers have been annihilating lefties in their last 5 games, with 9.5 runs per game, while the Cardinals average just 2.8 against righties in that span. Take the Brewers to win at home.

Nikos Lagouretos's Pick: Milwaukee Brewers ML