St. Louis Cardinals vs Milwaukee Brewers Prediction 5/25/2026 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Monday, May 25th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 30-20 record this season and are sitting in the first place of the NL Central. They have a 16-11 home record and are coming off a 1-5 home defeat against the Dodgers. They will face the Astros and the Giants next.

The Brewers have a .246 batting average this season, .333 OBP and .361 Slugging percentage. Milwaukee’s pitching staff has a 3.31 ERA and 1.21 WHIP. William Contreras is the team’s best hitter with a .303 batting average, also leading the team in RBI with 30. Jake Bauers adds a team-high 7 home runs.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 4-2 record, 1.89 ERA and 0.88 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 29-22 record this season and are sitting in the second place of the NL Central. They have a 16-9 away record and are coming off a 6-7 road defeat against the Reds. They will face the Cubs and the Rangers next.

The Cardinals have a .242 batting average this season, .323 OBP and .393 Slugging percentage. St. Louis’ pitching staff has a 4.20 ERA and 1.37 WHIP. Jordan Walker is the team’s best hitter with a .302 batting average, also leading the team in RBI with 42, adding a team-high 15 home runs.

Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 2-2 record, 4.70 ERA and 1.55 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: May 25, 2026

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 4-2      ERA: 1.89
• Home Record: 2-0
• Last 5 against Cardinals: 1-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 12 day games against NL Central opponents following a home loss.
• The Cardinals have lost five of their last six day games against National League opponents.
• The Brewers have covered the run line each of their last six day games against NL Central opponents that held a winning record.
• The Cardinals have failed to cover the run line in four of their last five day games against NL Central opponents following a loss.
• The Brewers have led after 3 innings in each of their last seven games against opponents that held a winning record.
• The Brewers have led after 5 innings in each of their last six games as home favorites.
• The Brewers have won the first inning in each of their last three games as favorites against National League opponents.

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 2-2      ERA: 4.70
• Road Record: 1-1
• Last 5 against Brewers: 2-0

Why the St. Louis Cardinals will win

• The Cardinals have won eight of their last nine games as road underdogs following a loss.
• The Brewers have lost three of their last four home games after playing the previous day.
• The Cardinals have covered the run line in each of their last nine road games following a loss.
• The Brewers have failed to cover the run line in 17 of their last 21 home games against National League opponents after playing the previous day.
• The Cardinals have led after 3 innings in each of their last five road games against NL Central opponents.
• The Cardinals have led after 5 innings in each of their last four games as road underdogs against NL Central opponents.

Total Runs Facts

• Seven of the Cardinals’ last eight games as road underdogs have gone UNDER the total runs line.
• Four of the Brewers’ last five games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cardinals’ last eight games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of Jacob Misiorowski’s last five home appearances as a starter.

Milwaukee Brewers Player Prop Facts

• Andrew Vaughn has hit a home run in each of his last two home appearances against NL Central opponents.
• Sal Frelick has recorded at least one hit in each of his last seven appearances against the Cardinals.
• Jacob Misiorowski ranks 2nd in the league for total Strikeouts (88) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in five of his last 20 road appearances after not playing the previous day.
• Alec Burleson has recorded at least one hit in each of his 11 previous appearances against the Brewers after not playing the previous day.
• Jordan Walker ranks 4th amongst qualified players for Slugging Percentage (.594) this season.

Matchup/League Facts

• The Brewers rank 30th in the league for home runs this season (34).
• The Brewers rank 1st in the league for home runs allowed this season (37).
• The Cardinals rank 29th in the league for strikeouts this season (380).
• The Cardinals rank T28th in the league for triples this season (3).

Cardinals vs Brewers Prediction

Both teams are tied 5-5 in their last 10 meetings but the Brewers are 3-1 in their last 4 meetings in Milwaukee.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -225 home favorites. The Brewers have the absolute pitching advantage in this game, as the Jacob Misiorowski goes up against Matthew Liberatore. Misiorowski has four straight shutouts, while Liberatore has given up 4 runs in each of his last two starts. The Brewers have a better offense and a superior bullpen and are coming off two bad losses against the Dodgers, so this is the perfect bounce-back spot. Take the Brewers on the runline in this one.

Nikos Lagouretos's Pick: Milwaukee Brewers -1.5