Jul 5, 2025; Chicago, Illinois, USA; St. Louis Cardinals pinch hitter Yohel Pozo (63) celebrates with teammates in the dugout after hitting a three-run home run during the eighth inning against the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

St. Louis Cardinals vs Chicago Cubs Prediction 07/06/2025 Picks

Pick details

St. Louis (48-42) vs Chicago (53-36)

July 6, 2025 at 06:10 PM EDT

The Line: Betting Odds: Chicago 0.0001 — Over/Under: 0.0001

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The St. Louis Cardinals and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a St. Louis Cardinals vs Chicago Cubs Prediction. This article will include a St. Louis Cardinals vs Chicago Cubs Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 48-42 on the year and play the Nationals and Braves next. The St. Louis Cardinals are batting .252 on the season, have a .322 OBP, and a .394 slugging percentage. The St. Louis Cardinals pitching staff has a 4.03 ERA and a 1.26 WHIP. Brendan Donovan leads the St. Louis Cardinals with 94 hits and 32 RBI, while Alec Burleson and Willson Contreras have combined for 154 hits and 89 RBI. 

Erick Fedde gets the ball for the St. Louis Cardinals, and he is 3-8 with a 4.56 ERA and 57 strikeouts this season. Fedde is 0-2 with a 7.92 ERA and 28 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 53-36 on the year and play the Twins and Yankees next. The Chicago Cubs are batting .256 on the season, have a .326 OBP, and a .450 slugging percentage. The Chicago Cubs pitching staff has a 3.82 ERA and a 1.24 WHIP. Kyle Tucker leads the Chicago Cubs with 94 hits and 52 RBI while Pete Crow-Armstrong and Nico Hoerner have combined for 184 hits and 102 RBI.
Matthew Boyd gets the ball for the Chicago Cubs, and he is 8-3 with a 2.65 ERA and 87 strikeouts this season. Boyd is 2-1 with a 1.57 ERA and 26 strikeouts in his career against the St. Louis Cardinals.

Why the Chicago Cubs will win

The Cubs have won seven of their last eight games at Wrigley Field following a loss.
The Cardinals have lost each of their last four games at Wrigley Field following a road win.
The Cubs have covered the run line in each of their last six Sunday night games as home favorites against NL Central opponents.
The Cardinals have failed to cover the run line in five of their last six games at Wrigley Field against teams that held a winning record.
The Cardinals have trailed after 3 innings in six of their last eight games against NL Central opponents.
The Cardinals have trailed after 5 innings in seven of their last eight Sunday night games as road underdogs.

Why the St. Louis Cardinals will win

The underdogs have won 13 of the last 18 games between the Cardinals and Cubs at Wrigley Field.
The Cubs have lost nine of their last 10 Sunday night games.
The Cardinals have covered the run line in 11 of their last 13 games as road underdogs against National League opponents.
The Cubs have failed to cover the run line in five of their last six home games against National League opponents after playing the previous day.

Chicago Cubs Player Prop Facts

Nico Hoerner has hit a home run in three of the Cubs’ last four night games against opponents that held a winning record.
Matthew Boyd has recorded a win in seven of his last eight appearances at Wrigley Field.
Matthew Boyd has recorded five or more strikeouts in five of his last six appearances at Wrigley Field.
Dansby Swanson has recorded at least one hit in each of the Cubs’ last eight games as favorites.
Seiya Suzuki ranks 6th in the league in Home Runs (24) this season.

St. Louis Cardinals Player Prop Facts

Lars Nootbaar has recorded at least one hit in each of his last six appearances after playing the previous day.
Lars Nootbaar has hit a home run in each of his last two appearances in night games against NL teams that held a winning record.

St. Louis Cardinals vs Chicago Cubs Prediction

The Cardinals won last night, but they’ve had issues stringing together offense over the last two weeks, and it makes them hard to back night to night. Fedde is coming off a rough June where he allowed 36 hits and 20 earned runs in 30.1 innings. The Cardinals have been shutout in Fedde’s last two starts. Boyd is having an all-star caliber season with a 2.65 ERA and 1.08 WHIP, and he has a 2.44 ERA and .212 allowed batting average in 48 home innings. I’m rolling with the Cubs on Sunday.

Randy Chambers's Pick: Chicago Cubs

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