St. Louis Cardinals vs Baltimore Orioles Prediction 5/26/25 MLB Picks

The St. Louis Cardinals and Baltimore Orioles meet Monday in MLB action at Oriole Park at Camden Yards. Here’s a St. Louis Cardinals vs Baltimore Orioles Prediction. This article will include a St. Louis Cardinals vs Baltimore Orioles Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 30-23 on the year and play the Rangers, Royals, and Dodgers next. The St. Louis Cardinals are batting .261 on the season, have a .332 OBP, and a .389 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.73 ERA and a 1.22 WHIP. Brendan Donovan leads the St. Louis Cardinals with 65 hits and 22 RBI, while Lars Nootbaar and Willson Contreras have combined for 95 hits and 53 RBI. 

Erick Fedde gets the ball for the St. Louis Cardinals, and he is 3-3 with a 3.77 ERA and 34 strikeouts this season. Fedde is 2-0 with a 0.38 ERA and 12 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 18-34 on the year and play the White Sox, Mariners, and Athletics next. The Baltimore Orioles are batting .234 on the season, have a .302 OBP, and a .386 slugging percentage. The Baltimore Orioles pitching staff has a 5.52 ERA and a 1.48 WHIP. Ryan O’Hearn leads the Baltimore Orioles with 49 hits and 18 RBI, while Gunnar Henderson and Jackson Holliday have combined for 92 hits and 36 RBI.

The Baltimore Orioles didn’t announce a starting pitcher at the time this article was published.

Why the Baltimore Orioles will win

• The Cardinals have lost each of their last six games against AL East opponents.
• The home team has won each of the last three games between the Cardinals and Orioles.
• The Cardinals have failed to cover the run line in four of their last five day games against AL East opponents that held a losing record.
• The home team has covered the run line in each of the last three games between the Cardinals and Orioles.
• The Orioles have led after 5 innings in each of their last three day games.

Why the St. Louis Cardinals will win

• The Orioles have lost each of their last eight games at Oriole Park at Camden Yards.
• The Cardinals have won seven of their last eight games against teams that held a losing record.
• The Orioles have failed to cover the run line in each of their last eight home games.
• The Cardinals have covered the run line in eight of their last nine road games.
• The Orioles have trailed after 3 innings in five of their last six games against National League opponents that held a winning record.
• The Orioles have trailed after 5 innings in four of their last five games against National League opponents.

Baltimore Orioles Player Prop Facts

• Gunnar Henderson has scored at least one run in four of the Orioles’ last five games.
• Charlie Morton has recorded six or more strikeouts in five of his last six home appearances against NL opponents.
• Ramon Urias has recorded a Single in each of his last seven appearances at Oriole Park at Camden Yards against NL opponents that held a winning record.
• Ramon Urias has recorded at least one hit in each of his last nine home appearances against NL opponents that held a winning record.
• Ramon Laureano has hit at least one home run in three of his last five appearances against NL Central opponents.
• Gary Sanchez has recorded at least one RBI in four of his last five appearances against NL Central opponents that held a winning record.
• Ryan O’Hearn ranks 5th amongst qualified players for On Base Percentage (.419) this season.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded at least one Double in three of the Cardinals’ last four road games against AL opponents.
• Lars Nootbaar has recorded at least one RBI in four of the Cardinals’ last five day games against opponents that held a losing record.
• Willson Contreras has scored a run in each of his four previous appearances at Oriole Park at Camden Yards against AL opponents that held a losing record.
• Brendan Donovan has recorded at least one Single in nine of the Cardinals’ last 10 day games against AL opponents that held a losing record.
• Willson Contreras has recorded at least one hit in each of his last seven road appearances against AL opponents that held a losing record.
• Nolan Gorman has hit at least one home run in two of his last three road appearances against AL opponents that held a losing record.
• Victor Scott II ranks T5th in the league in Steals (15) this season.

St. Louis Cardinals vs Baltimore Orioles Prediction

The Orioles didn’t announce a starting pitcher at the time this article was published, but it doesn’t matter. I’ve been fading the Orioles pretty much all season, and a couple of wins over the Red Sox don’t move the needle much. The Orioles are still 16 games below a .500 record, and only the Rockies have lost bettors more money this season. The Cardinals are coming off a nice sweep of the Diamondbacks, and Fedde is in a groove, allowing 20 hits and seven runs in his last 24.2 innings. In 29.2 road innings, Fedde has a 2.43 ERA and a .190 allowed batting average. Give me the Cardinals and the pick ’em price.