St. Louis Cardinals vs Atlanta Braves Prediction 4/22/25 MLB Picks

The St. Louis Cardinals and Atlanta Braves meet Tuesday in MLB action at Busch Stadium. Here’s a St. Louis Cardinals vs Atlanta Braves Prediction. This article will include a St. Louis Cardinals vs Atlanta Braves Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 9-14 on the year and play the Brewers, Reds, and Mets next. The St. Louis Cardinals are batting .264 on the season, have a .331 OBP, and a .405 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.38 ERA and a 1.21 WHIP. Brendan Donovan leads the St. Louis Cardinals with 32 hits and 13 RBI, while Nolan Arenado and Lars Nootbaar have combined for 42 hits and 21 RBI. 

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 2-1 with a 3.22 ERA and 15 strikeouts this season. Pallante is 0-1 with a 12.15 ERA and 6 strikeouts in his career against the Atlanta Braves.

Atlanta Braves Betting Preview

The Atlanta Braves are 9-13 on the year and play the Diamondbacks, Rockies, and Dodgers next. The Atlanta Braves are batting .232 on the season, have a .309 OBP, and a .391 slugging percentage. The Atlanta Braves pitching staff has a 4.28 ERA and a 1.31 WHIP. Austin Riley leads the Atlanta Braves with 25 hits and 15 RBI, while Marcell Ozuna and Ozzie Albies have combined for 40 hits and 20 RBI.

The Atlanta Braves didn’t list a starting pitcher at the time this article was published.

Why the Atlanta Braves will win

• The Cardinals have lost each of their last six road games against National League opponents.
• The home team has won each of the Braves’ last six games.
• The Cardinals have failed to cover the run line in 10 of their last 13 games against NL East opponents that held a losing record.

Why the St. Louis Cardinals will win

• The Braves have lost eight of their last nine night games against NL Central opponents following a win.
• The Cardinals have won eight of their last nine Tuesday night games as road underdogs against National League opponents.
• The Braves have failed to cover the run line in each of their last 11 games as home favorites against NL Central opponents.
• The Cardinals have covered the run line in seven of their last eight games at Truist Park.

Atlanta Braves Player Prop Facts

• Austin Riley has hit a home run in each of his last three home appearances against NL Central opponents.
• Marcell Ozuna has recorded at least one hit in each of the Braves’ last 11 games against the Cardinals at Truist Park.
• Ronald Acuna Jr. has recorded at least one RBI in eight of his last nine appearances against NL Central opponents at Truist Park.
• Bryan De La Cruz has recorded at least one Single in each of his last six appearances with his team as a home favorite.
• Bryan De La Cruz has scored a run in 10 of his last 11 home appearances against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded at least one Single in each of the Cardinals’ last eight games against NL opponents that held a losing record.
• Nolan Gorman has scored at least one run in each of his last seven road appearances against the Braves.
• Willson Contreras has hit a home run in each of his last three appearances against the Braves after playing the previous day.
• Nolan Gorman has recorded at least one Double in three of the Cardinals’ last four road games against NL East opponents that held a losing record.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last nine night games.
• Alec Burleson has recorded at least one RBI in five of the Cardinals’ last six games as underdogs against the Braves.

St. Louis Cardinals vs Atlanta Braves Prediction

It would be nice to know who the Braves are throwing out there on the mound, but it probably doesn’t matter. As good as Pallante has been through 22.1 innings, it doesn’t mean much if the Cards can’t produce offense. The Cardinals have lost five straight games and have been held to four or fewer runs in six of their last seven games. The Braves are finally showing signs of getting their act together with four straight wins, and the offense has picked up. I’ll side with the Braves at home and the cheap price, regardless of who is on the mound.