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Milwaukee Brewers vs San Francisco Giants Prediction 4/22/25 MLB Picks

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San Francisco Giants (15-8) vs Milwaukee Brewers (12-10)

April 22, 2025 at 09:45 PM EDT

The Line: Betting Odds: San Francisco Giants -130 / Milwaukee Brewers +110 — Over/Under: 7.5

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In this article, we will formulate a Milwaukee Brewers vs San Francisco Giants Prediction for this MLB game on Tuesday, April 22nd, at Oracle Park.  To formulate this prediction, we will look at: 

-The Giants’ recent form and recent player performance

-The Brewers’ recent form and recent player performance

-Recent Betting trends and streaks involving Milwaukee

-Recent Betting trends and streaks involving San Francisco

-Recent betting trends in games played between Milwaukee and San Francisco

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Giants and Brewers. 

Brewers Offense Looks to Bounce Back

The Brewers’ offense scored a grand total of two runs on Monday, and that wasn’t enough as they ended up losing by three runs. Caleb Durbin was the only bright spot for the Brewers, hitting a home run and driving in two RBIs. Priester didn’t have his best start, but the bullpen also struggled. The pitching wasn’t great, but if the offense doesn’t get going here, it might not really matter. 

The Brewers are averaging 5.09 runs while their pitching is giving up 4.59 runs per game. The offense is ranked 5th in the league while the pitching is ranked 20th. Jackson Chourio has hit five home runs and driven in 19 RBIs. Getting the start for the Brewers will be Jose Quintana, who sits with a 2-0 record and an ERA of 0.71. Against the Detroit Tigers, he went 5.2 innings, giving up four hits and one run. 

What a Start for the Giants


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It has been quite the start for the Giants to start the season, and they were able to pick up another win on Monday. The offense managed five runs, and that was enough to secure the win. Robbie Ray got the start, and he went five innings, giving up two runs. Patrick Bailey did have a strong game, finishing with a hit and driving in two RBIs. 

The Giants are averaging 5.05 runs while their pitching is giving up 3.68 runs per game. The offense is ranked 6th while the pitching is ranked 4th. Getting the start for Jordan Hicks who sits with a 1-2 record an an ERA of 6.04. Against the Philadelphia Phillies, he went seven innings, giving up six hits and five runs. 

Milwaukee Brewers vs San Francisco Giants Prediction

Both of these teams have good offenses, and there isn’t much of an advantage here in terms of that. In this game, though, the Brewers have a good advantage on the mound. Jose Quintana sits with an ERA of 0.71, and in his last start against the Tigers, he gave up only one run. The Giants’ bats are going to be ice cold here. The Giants are 1-7 in Hicks’ last 8 starts vs. a team with a winning record. Back the Brewers. 

Shane Mickle's Pick: Brewers ML

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