Seattle Mariners vs Minnesota Twins Prediction 4/28/2026 Today’s MLB Picks

The Seattle Mariners and the Minnesota Twins meet Tuesday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Minnesota Twins prediction.

Starting Pitching Matchup 

The Seattle Mariners will send out Logan Gilbert for the start here and GIlbert is 1-3 with a 4.36 ERA and 35 strikeouts this season. In his last five starts against the Twins, Gilbert is 2-1 with a 4.50 ERA and 25 strikeouts. The Twins will send out Joe Ryan for the start here and Ryan is 2-2 with a 3.90 ERA and 33 strikeouts this season. In his last five starts against the Mariners, Ryan is 1-3 with a 4.13 ERA and 32 strikeouts.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from an 11-4 loss at the hands of the Twins in Monday’s series opener to sit at 14-16 this season. After this series, the Mariners will head home for a set against the Kansas City Royals.

Mariners Have Four-Game Win Streak Snapped

Entering Monday, Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 27 hits with 3 doubles, a triple, 3 home runs and 14 RBIs and Cal Raleigh has 23 hits with 4 doubles, 6 home runs and 15 RBIs as well this season. Randy Arozarena has 29 hits with 8 doubles, 2 home runs and 11 RBIs as well on the year. Josh Naylor also has 21 hits with 3 home runs and 11 RBIs as well on the year. Julio Rodriguez has also added 28 hits with 3 doubles, 2 home runs and 10 RBIs.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their win over the Mariners from Monday to improve to 13-16 on the year. After this series, the Twins will take on the Toronto Blue Jays in a series at home.

Twins Snap Five-Game Slide

Going into Monday, Byron Buxton has 24 hits with 4 doubles, a triple, 5 home runs and 7 RBIs while Josh Bell’s added 22 hits with 5 doubles, 3 home runs and 16 RBIs. Luke Keaschall has 22 hits with 3 doubles, a homer and 12 RBIs and Matt Wallner has 16 hits with a pair of doubles, 3 home runs and 7 RBIs. Brooks Lee has 5 home runs with 15 RBIs and Victor Caratini has 11 RBIs while Ryan Jeffers has 18 hits with 2 doubles, a triple, 3 home runs and 16 RBIs this season.

Seattle Mariners @ Minnesota Twins Betting Trends: April 28, 2026

• Probable Starting Pitcher: Joe Ryan      Record this season: 2-2      ERA: 3.90
• Home Record: 1-1
• Last 5 against Mariners: 1-3

Why the Minnesota Twins will win

• The underdogs have won nine of the Twins’ last 10 games at Target Field.
• The Mariners have lost each of their last five games as road favorites against American League opponents.
• The Mariners have failed to cover the run line in nine of their last 10 games as road favorites.
• The underdogs have covered the run line in nine of the Twins’ last 10 games at Target Field.
• The Twins have led after 5 innings in each of their last six night games at Target Field against American League opponents.
• The Twins have led after 3 innings in each of their last five night games against American League opponents that held a losing record.
• The Twins have won the first inning in four of their last five night games against American League opponents that held a losing record.

• Probable Starting Pitcher: Logan Gilbert      Record this season: 1-3      ERA: 4.36
• Road Record: 0-1
• Last 5 against Twins: 2-1

Why the Seattle Mariners will win

• The Twins have lost eight of their last nine games after playing the previous day.
• The Mariners have won eight of their last nine night games against the Twins following a road loss.
• The Twins have failed to cover the run line in each of their last seven games as home underdogs against AL West opponents following a win.
• The Mariners have covered the run line in eight of their last nine night games at Target Field following a loss.
• The Twins have trailed after 5 innings in seven of their last eight games as underdogs.
• The Twins have trailed after 3 innings in four of their last five games against opponents that held a losing record.
• The Mariners have won the first inning in four of their last five games against opponents that held a losing record.

Total Runs Facts

• Seven of the last eight games between the Mariners and Twins at Target Field have gone OVER the total runs line.
• Six of the Mariners’ last seven games as favorites against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last eight home games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Logan Gilbert’s last six appearances as a starter.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in five of the Twins’ last six night games against opponents that held a losing record.
• Joe Ryan has recorded a win in five of his last six appearances against AL opponents that held a losing record.
• Joe Ryan has recorded six or more strikeouts in seven of his last eight appearances against AL West opponents.
• Trevor Larnach has recorded at least one hit in each of his last 12 appearances with the Twins as underdogs against AL West opponents.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in each of the Mariners’ last four games against AL opponents.
• Logan Gilbert has recorded a win in each of his last three appearances with the Mariners as road favorites.
• Logan Gilbert has recorded six or more strikeouts in 17 of his last 18 appearances against AL opponents that held a losing record.
• Brendan Donovan has recorded at least one hit in each of his last 12 Tuesday appearances against teams that held a losing record.
• Randy Arozarena ranks T9th in the league in Steals (7) this season.

Matchup/League Facts

• The Twins rank 29th in the league for doubles this season (35).
• The Twins rank T3rd in the league for home runs allowed this season (23).
• The Mariners rank 1st in the league for walks allowed this season (76).
• The Mariners rank T27th in the league for hits allowed this season (260).

Seattle Mariners vs. Minnesota Twins Prediction

I’m on the Mariners here. The Twins got off the schneid last time out, but this Twins team has been struggling overall as of late and I think this is a spot for the Mariners to get a little bit of revenge and bounce back on Tuesday. Give me Seattle in this one.

Chris Ruffolo's Pick: Seattle -145