Seattle Mariners vs Houston Astros Prediction 9/19/2025 Today’s MLB Picks

The Seattle Mariners and Houston Astros meet Friday in MLB action at Daikin Park. Here’s a Seattle Mariners vs Houston Astros Prediction. This article will include a Seattle Mariners vs Houston Astros Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 84-69 on the year and play the Rockies and Dodgers next. The Seattle Mariners are batting .244 on the season, have a .320 OBP, and a .419 slugging percentage. The Seattle Mariners pitching staff has a 3.91 ERA and a 1.24 WHIP. Julio Rodriguez leads the Seattle Mariners with 168 hits and 93 RBI, while J.P. Crawford and Cal Raleigh have combined for 283 hits and 172 RBI.

Bryan Woo gets the ball for the Seattle Mariners, and he is 14-7 with a 3.02 ERA and 191 strikeouts this season. Woo is 1-2 with a 3.42 ERA and 20 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 84-69 on the year and play the Athletics and Angels next. The Houston Astros are batting .252 on the season, have a .318 OBP, and a .400 slugging percentage. The Houston Astros pitching staff has a 3.83 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 148 hits and 74 RBI while Jeremy Pena and Yainer Diaz have combined for 279 hits and 126 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 12-7 with a 2.27 ERA and 192 strikeouts this season. Brown is 1-3 with a 4.26 ERA and 50 strikeouts in his career against the Seattle Mariners.

Seattle Mariners @ Houston Astros Betting Trends: September 19, 2025

• Probable Starting Pitcher: Hunter Brown      Record this season: 12-7      ERA: 2.27
• Home Record: 5-5
• Last 5 against Mariners: 1-1

Why the Houston Astros will win

• The Mariners have lost each of their last six road games against AL West opponents following a road win.
• The Astros have won seven of their last eight home games against AL West opponents that held a winning record.
• The Mariners have failed to cover the run line in each of their last nine road games against AL West opponents following a road win.
• The Astros have covered the run line in each of their last seven night games against American League opponents.
• The Mariners have lost the first inning in each of their last three games as road underdogs against American League opponents.
• The Mariners have trailed after 3 innings in five of their last six games as road underdogs.
• The Mariners have trailed after 5 innings in six of their last seven games as road underdogs.

• Probable Starting Pitcher: Bryan Woo      Record this season: 14-7      ERA: 3.02
• Road Record: 4-5
• Last 5 against Astros: 1-2

Why the Seattle Mariners will win

• The Mariners have won 13 of their last 15 games as underdogs against AL West opponents.
• The Astros have lost six of their last seven games as favorites against the Mariners following a win.
• The Mariners have covered the run line in each of their last nine games as road underdogs against the Astros following a win.
• The Astros have failed to cover the run line in 10 of their last 11 games as favorites against American League opponents following a home win.

Total Runs Facts

• Seven of the Mariners’ last eight games as underdogs against American League opponents have gone OVER the total runs line.
• Four of the Astros’ last five home games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last five games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last four games.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in four of his last seven appearances at Daikin Park against AL West opponents that held a winning record.
• Jeremy Pena has recorded at least one Double in three of the Astros’ last four home games against AL West opponents.
• Ramon Urias has recorded at least one hit in each of his last nine home appearances against AL West opponents.
• Jeremy Pena is one of only seven players to hit over .300 and have 45+ RBIs this season.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in four of the Mariners’ last five road games against AL opponents that held a winning record.
• Jorge Polanco has recorded at least one Double in each of the Mariners’ last four games against AL West opponents.
• J.P. Crawford has recorded at least one hit in each of the Mariners’ last eight games as underdogs against AL opponents.
• Cal Raleigh ranks 3rd amongst qualified players for Slugging Percentage (.585) this season.

Matchup/League Facts

• The Astros rank T4th in the league for hits allowed this season (1185).
• The Astros rank 26th in the league for triples this season (12).
• The Mariners rank 3rd in the league for home runs this season (223).
• The Mariners are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Seattle Mariners vs Houston Astros Prediction

You can make a case for the Mariners as they’ve caught fire over the last month, and Woo has been solid this season with a 3.02 ERA and 0.94 WHIP. However, the Astros are at home, and they’re a team that knows how to win down the stretch. Brown has also been a top-10 pitcher in baseball with a 2.27 ERA and 1.00 WHIP. In 80 home innings, Brown has a 2.25 ERA and .183 allowed batting average. Brown has allowed 3 runs in his last 18.2 innings. Great series and even better pitching matchup. Give me the Astros.